MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome. All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected. Rifampicin plus fusidic acid was the most frequently used regimen (24 (65%) out of 37 patients), with an overall success rate of 79% (19 out of 24 patients). Eradication failure was more likely in patients with an additional MRSA-positive peripheral screening swab (p=0.03) and was associated with worse survival (p=0.04). Our results demonstrate the feasibility and clinical benefits of MRSA eradication. As peripheral colonisation was associated with lower eradication success, strategies combining systemic and topical treatments should be considered to optimise outcomes in CF patients

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication

By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication. In these initiatives, some types of research commenced as the programs began and proceeded in parallel. Basic laboratory, clinical, and field research all contributed notably to progress made in the viral programs. For each program, vaccine was the lynchpin intervention, but as the programs progressed, research was required to improve vaccine formulations, delivery methods, and immunization schedules. Surveillance was fundamental to all three programs, whilst polio eradication also required improved diagnostic methods to identify asymptomatic infections. Molecular characterization of pathogen isolates strengthened surveillance and allowed insights into the geographic source of infections and their spread. Anthropologic, sociologic, and behavioural research were needed to address cultural and religious beliefs to expand community acceptance. The last phases of elimination and eradication became increasingly difficult, as a nil incidence was approached. Any eradication initiative for malaria must incorporate flexible research agendas that can adapt to changing epidemiologic contingencies and allow planning for posteradication scenarios. © 2011 Breman et al

Eradication, Containment, Management and Restoration. A report to the European Commission Working Group 3 on Invasive Species Policy

• Working Group Invasive Species n. 3 • Task 3.1: Eradication, Containment, Management and Restoration o Objective o Scope o Definitions o Eradication o Containment o Mitigation o Coexistence and Acceptance o Restoration o The Role of EU and MS o Practical considerations o References OBJECTIVE To minimise the damage caused by established IAS to species, habitats, ecosystem function and services, economic activities, together with human and animal health. To be achieved, where possible, by the eradication of IAS and, where impractical, the limitation of their impact, further spread and management of the consequences

"The Impact of Malaria Eradication on Fertility"

The malaria eradication campaign that started in Sri Lanka in the late 1940s virtually eliminated malaria transmission on the island. I use the pre-eradication differences in malaria endemicity within Sri Lanka to identify the effect of malaria eradication on fertility and child survival. Malaria eradication increased the number of live births through increasing age specific fertility and causing an earlier first birth. The effect of malaria on the transition time to higher order births is inconclusive. Malaria could directly or indirectly affect survival probabilities of live births. I exploit the particular epidemiology of malaria that causes more severe sequelae during an initial pregnancy. I find differential changes in survival probabilities by birth order that are most likely due to the direct in utero effects of malaria. The increase in population growth after malaria eradication reconciles the contradictory findings in the macroeconomic and microeconomic literatures: the increased productivity and education from malaria eradication will only appear in aggregate measures like GDP per capita after a delay because of the initial increase in the population size.malaria, fertility, disease eradication

Optimal Disease Eradication

Using a dynamic model of the control of an infectious disease, we derive the conditions under which eradication will be optimal. When eradication is feasible, the optimal program requires either a low vaccination rate or eradication. A high vaccination rate is never optimal. Under special conditions, the results are especially stark: the optimal policy is either not to vaccinate at all or to eradicate. Our analysis yields a cost-benefit rule for eradication, which we apply to the current initiative to eradicate polio.Eradication of infectious diseases; vaccination; control theory; cost-benefit analysis; poliomyelitis

Deconstructing the eradication of new world screwworm in North America: retrospective analysis and climate warming effects.

Before its eradication from North America, the subtropical-tropical new world screwworm fly Cochliomyia hominivorax (Coquerel) invaded southwestern temperate areas of the U.S.A., where it caused myiasis in wildlife and livestock. Outbreaks of the fly occurred during years when adult migrants were carried northward on North American monsoon winds from the northern areas of Mexico and south Texas. We deconstruct, retrospectively, the biology and the effect of weather on the eradication of the fly in North America. Screwworm was found to be an ideal candidate for eradication using the sterile insect technique (SIT) because females mate only once, whereas males are polygynous, and, although it has a high reproductive potential, field population growth rates are low in tropical areas. In northern areas, eradication was enhanced by cool-cold weather, whereas eradication in tropical Mexico and Central America is explained by the SIT. Despite low average efficacy of SIT releases (approximately 1.7%), the added pressure of massive SIT releases reduced intrinsically low fly populations, leading to mate-limited extinction. Non-autochthonous cases of myiasis occur in North America and, if the fly reestablishes, climate warming by 2045-2055 will expand the area of favourability and increase the frequency and severity of outbreaks

Eradication of Exotic Weeds in Australia: Comparing Effort and Expenditure

Weeds have many adverse impacts on agriculture and the environment and therefore are often targets of eradication attempts. Eradication attempts involve large commitments of labour and financial resources over significant periods of time. Using data from 12 Australian weed eradication attempts the authors compare work hours and expenditure on each attempt for various initial-infestation sizes. Analysis of a limited data set shows: (1) that while the eradication effort increases with the initial area of infestation, the effort applied per hectare actually decreases; (2) that application of a greater work effort was not the reason why completed eradications were successful; and (3) that the larger the initial infestation size, the smaller the amount of resources applied per hectare for eradication.weeds, eradication, work effort, expenditure, infestation size, Environmental Economics and Policy, Resource /Energy Economics and Policy,

Optimal Disease Eradication

Using a dynamic model of the control of an infectious disease, we derive the conditions under which eradication will be optimal. When eradication is feasible, the optimal program requires either a low vaccination rate or eradication. A high vaccination rate is never optimal. Under special conditions, the results are especially stark: the optimal policy is either not to vaccinate at all or to eradicate. Our analysis yields a cost-benefit rule for eradication, which we apply to the current initiative to eradicate polio.Eradication of infectious diseases, Vaccination, Control theory, Cost-benefit analysis, Poliomyelitis

Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector

The aim of this study was to conduct an economic evaluation of the BVD eradication program in the Swiss dairy sector. The situation before the start of the program (herd-level prevalence: 20%) served as a baseline scenario. Production models for three dairy farm types were used to estimate gross margins as well as net production losses and expenditures caused by BVD. The total economic benefit was estimated as the difference in disease costs between the baseline scenario and the implemented eradication program and was compared to the total eradication costs in a benefit-cost analysis. Data on the impact of BVD virus (BVDV) infection on animal health, fertility and production parameters were obtained empirically in a retrospective epidemiological case-control study in Swiss dairy herds and complemented by literature. Economic and additional production parameters were based on benchmarking data and published agricultural statistics. The eradication costs comprised the cumulative expenses for sampling and diagnostics. The economic model consisted of a stochastic simulation in @Risk for Excel with 20,000 iterations and was conducted for a time period of 14 years (2008–2021)

The Economic Effects of Malaria Eradication: Evidence from an Intervention in Uganda

This study evaluates the economic consequences of a malaria eradication campaign in the southwestern Ugandan district of Kigezi. The project was a joint venture between the WHO and Uganda's Ministry of Health, designed to test for the first time the feasibility of malaria eradication in a sub-Saharan African country. During the years of 1959 and 1960, eradication efforts employing DDT spraying and mass distribution of anti-malarials were implemented, beginning in northern Kigezi. Follow-up studies reported a drop in overall parasite rates from 22.7 to 0.5% in hyperendemic areas and from 12.5 to 0% in mesoendemic areas. We use this campaign as a plausibly exogenous health shock to explore changes in human-capital formation and income. We employ a difference-in-difference methodology to show that eradication produced differential improvements in Kigezi compare to the rest of Uganda in years of schooling, literacy, and primary school completion. In addition, we find suggestive evidence that eradication increased income levels.human capital, malaria, economic development and health