Human and Artificial Intelligence

Although tremendous advances have been made in recent years, many real-world problems still cannot be solved by machines alone. Hence, the integration between Human Intelligence and Artificial Intelligence is needed. However, several challenges make this integration complex. The aim of this Special Issue was to provide a large and varied collection of high-level contributions presenting novel approaches and solutions to address the above issues. This Special Issue contains 14 papers (13 research papers and 1 review paper) that deal with various topics related to human–machine interactions and cooperation. Most of these works concern different aspects of recommender systems, which are among the most widespread decision support systems. The domains covered range from healthcare to movies and from biometrics to cultural heritage. However, there are also contributions on vocal assistants and smart interactive technologies. In summary, each paper included in this Special Issue represents a step towards a future with human–machine interactions and cooperation. We hope the readers enjoy reading these articles and may find inspiration for their research activities

Ensemble of rankers for efficient gene signature extraction in smoke exposure classification

Abstract Background System toxicology aims at understanding the mechanisms used by biological systems to respond to toxicants. Such understanding can be leveraged to assess the risk of chemicals, drugs, and consumer products in living organisms. In system toxicology, machine learning techniques and methodologies are applied to develop prediction models for classification of toxicant exposure of biological systems. Gene expression data (RNA/DNA microarray) are often used to develop such prediction models. Results The outcome of the present work is an experimental methodology to develop prediction models, based on robust gene signatures, for the classification of cigarette smoke exposure and cessation in humans. It is a result of the participation in the recent sbv IMPROVER SysTox Computational Challenge. By merging different gene selection techniques, we obtain robust gene signatures and we investigate prediction capabilities of different off-the-shelf machine learning techniques, such as artificial neural networks, linear models and support vector machines. We also predict six novel genes in our signature, and firmly believe these genes have to be further investigated as biomarkers for tobacco smoking exposure. Conclusions The proposed methodology provides gene signatures with top-ranked performances in the prediction of the investigated classification methods, as well as new discoveries in genetic signatures for bio-markers of the smoke exposure of humans