11,781 research outputs found
A Survey on Soft Subspace Clustering
Subspace clustering (SC) is a promising clustering technology to identify
clusters based on their associations with subspaces in high dimensional spaces.
SC can be classified into hard subspace clustering (HSC) and soft subspace
clustering (SSC). While HSC algorithms have been extensively studied and well
accepted by the scientific community, SSC algorithms are relatively new but
gaining more attention in recent years due to better adaptability. In the
paper, a comprehensive survey on existing SSC algorithms and the recent
development are presented. The SSC algorithms are classified systematically
into three main categories, namely, conventional SSC (CSSC), independent SSC
(ISSC) and extended SSC (XSSC). The characteristics of these algorithms are
highlighted and the potential future development of SSC is also discussed.Comment: This paper has been published in Information Sciences Journal in 201
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics.
BackgroundSingle-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. It can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully differentiated cells. While a variety of statistical and computational methods have been proposed for inferring cell lineages, the problem of accurately characterizing multiple branching lineages remains difficult to solve.ResultsWe introduce Slingshot, a novel method for inferring cell lineages and pseudotimes from single-cell gene expression data. In previously published datasets, Slingshot correctly identifies the biological signal for one to three branching trajectories. Additionally, our simulation study shows that Slingshot infers more accurate pseudotimes than other leading methods.ConclusionsSlingshot is a uniquely robust and flexible tool which combines the highly stable techniques necessary for noisy single-cell data with the ability to identify multiple trajectories. Accurate lineage inference is a critical step in the identification of dynamic temporal gene expression
A novel ensemble method for electric vehicle power consumption forecasting: Application to the Spanish system
The use of electric vehicle across the world has become one of the most challenging issues for environmental policies. The galloping climate change and the expected running out of fossil fuels turns the use of such non-polluting cars into a priority for most developed countries. However, such a use has led to major concerns to power companies, since they must adapt their generation to a new scenario, in which electric vehicles will dramatically modify the curve of generation. In this paper, a novel approach based on ensemble learning is proposed. In particular, ARIMA, GARCH and PSF algorithms' performances are used to forecast the electric vehicle power consumption in Spain. It is worth noting that the studied time series of consumption is non-stationary and adds difficulties to the forecasting process. Thus, an ensemble is proposed by dynamically weighting all algorithms over time. The proposal presented has been implemented for a real case, in particular, at the Spanish Control Centre for the Electric Vehicle. The performance of the approach is assessed by means of WAPE, showing robust and promising results for this research field.Ministerio de Economía y Competitividad Proyectos ENE2016-77650-R, PCIN-2015-04 y TIN2017-88209-C2-R
Evolving Ensemble Fuzzy Classifier
The concept of ensemble learning offers a promising avenue in learning from
data streams under complex environments because it addresses the bias and
variance dilemma better than its single model counterpart and features a
reconfigurable structure, which is well suited to the given context. While
various extensions of ensemble learning for mining non-stationary data streams
can be found in the literature, most of them are crafted under a static base
classifier and revisits preceding samples in the sliding window for a
retraining step. This feature causes computationally prohibitive complexity and
is not flexible enough to cope with rapidly changing environments. Their
complexities are often demanding because it involves a large collection of
offline classifiers due to the absence of structural complexities reduction
mechanisms and lack of an online feature selection mechanism. A novel evolving
ensemble classifier, namely Parsimonious Ensemble pENsemble, is proposed in
this paper. pENsemble differs from existing architectures in the fact that it
is built upon an evolving classifier from data streams, termed Parsimonious
Classifier pClass. pENsemble is equipped by an ensemble pruning mechanism,
which estimates a localized generalization error of a base classifier. A
dynamic online feature selection scenario is integrated into the pENsemble.
This method allows for dynamic selection and deselection of input features on
the fly. pENsemble adopts a dynamic ensemble structure to output a final
classification decision where it features a novel drift detection scenario to
grow the ensemble structure. The efficacy of the pENsemble has been numerically
demonstrated through rigorous numerical studies with dynamic and evolving data
streams where it delivers the most encouraging performance in attaining a
tradeoff between accuracy and complexity.Comment: this paper has been published by IEEE Transactions on Fuzzy System
Methods for protein complex prediction and their contributions towards understanding the organization, function and dynamics of complexes
Complexes of physically interacting proteins constitute fundamental
functional units responsible for driving biological processes within cells. A
faithful reconstruction of the entire set of complexes is therefore essential
to understand the functional organization of cells. In this review, we discuss
the key contributions of computational methods developed till date
(approximately between 2003 and 2015) for identifying complexes from the
network of interacting proteins (PPI network). We evaluate in depth the
performance of these methods on PPI datasets from yeast, and highlight
challenges faced by these methods, in particular detection of sparse and small
or sub- complexes and discerning of overlapping complexes. We describe methods
for integrating diverse information including expression profiles and 3D
structures of proteins with PPI networks to understand the dynamics of complex
formation, for instance, of time-based assembly of complex subunits and
formation of fuzzy complexes from intrinsically disordered proteins. Finally,
we discuss methods for identifying dysfunctional complexes in human diseases,
an application that is proving invaluable to understand disease mechanisms and
to discover novel therapeutic targets. We hope this review aptly commemorates a
decade of research on computational prediction of complexes and constitutes a
valuable reference for further advancements in this exciting area.Comment: 1 Tabl
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