Improving Community Advisory Board Engagement In Precision Medicine Research To Reduce Health Disparities

Community Advisory Boards (CABs) are used in efforts to reduce health disparities; however, there is little documentation in the literature regarding their use in precision medicine research. In this case study, an academic-CAB partnership developed a questionnaire and patient educational materials for two precision smoking cessation interventions that involved use of genetic information. The community-engaged research (CEnR) literature provided a framework for enhancing benefits to CAB members involved in developing research documents for use with a low-income, ethnically diverse population of smokers. The academic partners integrated three CEnR strategies: 1) in-meeting statements acknowledging their desire to learn from community partners, 2) in-meeting written feedback to and from community partners, and 3) a survey to obtain CAB member feedback post-meetings. Strategies 1 and 2 yielded modifications to pertinent study materials, as well as suggestions for improving meeting operations that were then adopted, as appropriate, by the academic partners. The survey indicated that CAB members valued the meeting procedure changes which appeared to have contributed to improvements in attendance and satisfaction with the meetings. Further operationalization of relevant partnership constructs and development of tools for measuring these aspects of community-academic partnerships is warranted to support community engagement in precision medicine research studies

Dynamic Geospatial Spectrum Modelling: Taxonomy, Options and Consequences

Much of the research in Dynamic Spectrum Access (DSA) has focused on opportunistic access in the temporal domain. While this has been quite useful in establishing the technical feasibility of DSA systems, it has missed large sections of the overall DSA problem space. In this paper, we argue that the spatio-temporal operating context of specific environments matters to the selection of the appropriate technology for learning context information. We identify twelve potential operating environments and compare four context awareness approaches (on-board sensing, databases, sensor networks, and cooperative sharing) for these environments. Since our point of view is overall system cost and efficiency, this analysis has utility for those regulators whose objectives are reducing system costs and enhancing system efficiency. We conclude that regulators should pay attention to the operating environment of DSA systems when determining which approaches to context learning to encourage

Longitude : a privacy-preserving location sharing protocol for mobile applications

Location sharing services are becoming increasingly popular. Although many location sharing services allow users to set up privacy policies to control who can access their location, the use made by service providers remains a source of concern. Ideally, location sharing providers and middleware should not be able to access users’ location data without their consent. In this paper, we propose a new location sharing protocol called Longitude that eases privacy concerns by making it possible to share a user’s location data blindly and allowing the user to control who can access her location, when and to what degree of precision. The underlying cryptographic algorithms are designed for GPS-enabled mobile phones. We describe and evaluate our implementation for the Nexus One Android mobile phone

A community based approach for managing ontology alignments

The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect. Various ontology mapping techniques and tools have been devised to facilitate the bridging and integration of distributed data repositories. Nevertheless, ontology mapping can benefitfrom human supervision to increase accuracy of results. The spread of Web 2.0 approaches demonstrate the possibility of using collaborative techniques for reaching consensus. While a number of prototypes for collaborative ontology construction are being developed, collaborative ontology mapping is not yet well investigated. In this paper, we describe a prototype that combines off-the-shelf ontology mapping tools with social software techniques to enable users to collaborate on mapping ontologies

S-OHEM: Stratified Online Hard Example Mining for Object Detection

One of the major challenges in object detection is to propose detectors with highly accurate localization of objects. The online sampling of high-loss region proposals (hard examples) uses the multitask loss with equal weight settings across all loss types (e.g, classification and localization, rigid and non-rigid categories) and ignores the influence of different loss distributions throughout the training process, which we find essential to the training efficacy. In this paper, we present the Stratified Online Hard Example Mining (S-OHEM) algorithm for training higher efficiency and accuracy detectors. S-OHEM exploits OHEM with stratified sampling, a widely-adopted sampling technique, to choose the training examples according to this influence during hard example mining, and thus enhance the performance of object detectors. We show through systematic experiments that S-OHEM yields an average precision (AP) improvement of 0.5% on rigid categories of PASCAL VOC 2007 for both the IoU threshold of 0.6 and 0.7. For KITTI 2012, both results of the same metric are 1.6%. Regarding the mean average precision (mAP), a relative increase of 0.3% and 0.5% (1% and 0.5%) is observed for VOC07 (KITTI12) using the same set of IoU threshold. Also, S-OHEM is easy to integrate with existing region-based detectors and is capable of acting with post-recognition level regressors.Comment: 9 pages, 3 figures, accepted by CCCV 201

Optimal Degree of Public Information Dissemination

Financial markets and macroeconomic environments are often characterized by positive externalities. In these environments, transparency may reduce expected welfare from an ex-ante point of view: public announcements serve as a focal point for higher-order beliefs and affect agents’ behaviour more than justified by their informational contents. Some scholars conclude that it might be better to reduce the precision of public signals or entirely withhold information. This paper shows that public information should always be provided with maximum precision, but under certain conditions not to all agents. Restricting the degree of publicity is a better-suited instrument for preventing the negative welfare effects of public announcements than restrictions on their precision are

Enhanced sharing analysis techniques: a comprehensive evaluation

Sharing, an abstract domain developed by D. Jacobs and A. Langen for the analysis of logic programs, derives useful aliasing information. It is well-known that a commonly used core of techniques, such as the integration of Sharing with freeness and linearity information, can significantly improve the precision of the analysis. However, a number of other proposals for refined domain combinations have been circulating for years. One feature that is common to these proposals is that they do not seem to have undergone a thorough experimental evaluation even with respect to the expected precision gains. In this paper we experimentally evaluate: helping Sharing with the definitely ground variables found using Pos, the domain of positive Boolean formulas; the incorporation of explicit structural information; a full implementation of the reduced product of Sharing and Pos; the issue of reordering the bindings in the computation of the abstract mgu; an original proposal for the addition of a new mode recording the set of variables that are deemed to be ground or free; a refined way of using linearity to improve the analysis; the recovery of hidden information in the combination of Sharing with freeness information. Finally, we discuss the issue of whether tracking compoundness allows the computation of more sharing information

Systematizing Genome Privacy Research: A Privacy-Enhancing Technologies Perspective

Rapid advances in human genomics are enabling researchers to gain a better understanding of the role of the genome in our health and well-being, stimulating hope for more effective and cost efficient healthcare. However, this also prompts a number of security and privacy concerns stemming from the distinctive characteristics of genomic data. To address them, a new research community has emerged and produced a large number of publications and initiatives. In this paper, we rely on a structured methodology to contextualize and provide a critical analysis of the current knowledge on privacy-enhancing technologies used for testing, storing, and sharing genomic data, using a representative sample of the work published in the past decade. We identify and discuss limitations, technical challenges, and issues faced by the community, focusing in particular on those that are inherently tied to the nature of the problem and are harder for the community alone to address. Finally, we report on the importance and difficulty of the identified challenges based on an online survey of genome data privacy expertsComment: To appear in the Proceedings on Privacy Enhancing Technologies (PoPETs), Vol. 2019, Issue