A subspace preconditioned LSQR Gauss-Newton method with a constrained line search path applied to 3D biomedical microwave imaging

Three contributions that can improve the performance of a Newton-type iterative quantitative microwave imaging algorithm in a biomedical context are proposed. (i) To speed up the iterative forward problem solution, we extrapolate the initial guess of the field from a few field solutions corresponding to previous source positions for the same complex permittivity (i.e., “marching on in source position”) as well as from a Born-type approximation that is computed from a field solution corresponding to one previous complex permittivity profile for the same source position. (ii) The regularized Gauss-Newton update system can be ill-conditioned; hence we propose to employ a two-level preconditioned iterative solution method. We apply the subspace preconditioned LSQR algorithm from Jacobsen et al. (2003) and we employ a 3D cosine basis. (iii) We propose a new constrained line search path in the Gauss-Newton optimization, which incorporates in a smooth manner lower and upper bounds on the object permittivity, such that these bounds never can be violated along the search path. Single-frequency reconstructions from bipolarized synthetic data are shown for various three-dimensional numerical biological phantoms, including a realistic breast phantom from the University of Wisconsin-Madison (UWCEM) online repository

Spatial priors for tomographic reconstructions from limited data

Tomografie is het reconstrueren van het inwendige van een object a.d.h.v externe metingen, b.v. beelden verkregen met X-stralen of microgolven. Deze thesis bekijkt de specifieke aspecten van microgolftomografie en magnetische resonantie beeldvorming (Magnetic Resonance Imaging – MRI); beide technieken zijn onschadelijk voor de mens. Terwijl het gebruik van MRI wijdverspreid is voor veel klinische toepassingen, is microgolftomografie nog niet in klinisch gebruik ondanks zijn potentiële voordelen. Door de lage kost en draagbaarheid van de toestellen is het een waardevolle aanvulling aan het assortiment