23,755 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Feature selection in high-dimensional dataset using MapReduce
This paper describes a distributed MapReduce implementation of the minimum
Redundancy Maximum Relevance algorithm, a popular feature selection method in
bioinformatics and network inference problems. The proposed approach handles
both tall/narrow and wide/short datasets. We further provide an open source
implementation based on Hadoop/Spark, and illustrate its scalability on
datasets involving millions of observations or features
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