Classification and Segmentation of Galactic Structuresin Large Multi-spectral Images

Extensive and exhaustive cataloguing of astronomical objects is imperative for studies seeking to understand mechanisms which drive the universe. Such cataloguing tasks can be tedious, time consuming and demand a high level of domain specific knowledge. Past astronomical imaging surveys have been catalogued through mostly manual effort. Immi-nent imaging surveys, however, will produce a magnitude of data that cannot be feasibly processed through manual cataloguing. Furthermore, these surveys will capture objects fainter than the night sky, termed low surface brightness objects, and at unprecedented spatial resolution owing to advancements in astronomical imaging. In this thesis, we in-vestigate the use of deep learning to automate cataloguing processes, such as detection, classification and segmentation of objects. A common theme throughout this work is the adaptation of machine learning methods to challenges specific to the domain of low surface brightness imaging.We begin with creating an annotated dataset of structures in low surface brightness images. To facilitate supervised learning in neural networks, a dataset comprised of input and corresponding ground truth target labels is required. An online tool is presented, allowing astronomers to classify and draw over objects in large multi-spectral images. A dataset produced using the tool is then detailed, containing 227 low surface brightness images from the MATLAS survey and labels made by four annotators. We then present a method for synthesising images of galactic cirrus which appear similar to MATLAS images, allowing pretraining of neural networks.A method for integrating sensitivity to orientation in convolutional neural networks is then presented. Objects in astronomical images can present in any given orientation, and thus the ability for neural networks to handle rotations is desirable. We modify con-volutional filters with sets of Gabor filters with different orientations. These orientations are learned alongside network parameters during backpropagation, allowing exact optimal orientations to be captured. The method is validated extensively on multiple datasets and use cases.We propose an attention based neural network architecture to process global contami-nants in large images. Performing analysis of low surface brightness images requires plenty of contextual information and local textual patterns. As a result, a network for processing low surface brightness images should ideally be able to accommodate large high resolu-tion images without compromising on either local or global features. We utilise attention to capture long range dependencies, and propose an efficient attention operator which significantly reduces computational cost, allowing the input of large images. We also use Gabor filters to build an attention mechanism to better capture long range orientational patterns. These techniques are validated on the task of cirrus segmentation in MAT-LAS images, and cloud segmentation on the SWIMSEG database, where state of the art performance is achieved.Following, cirrus segmentation in MATLAS images is further investigated, and a com-prehensive study is performed on the task. We discuss challenges associated with cirrus segmentation and low surface brightness images in general, and present several tech-niques to accommodate them. A novel loss function is proposed to facilitate training of the segmentation model on probabilistic targets. Results are presented on the annotated MATLAS images, with extensive ablation studies and a final benchmark to test the limits of the detailed segmentation pipeline.Finally, we develop a pipeline for multi-class segmentation of galactic structures and surrounding contaminants. Techniques of previous chapters are combined with a popu-lar instance segmentation architecture to create a neural network capable of segmenting localised objects and extended amorphous regions. The process of data preparation for training instance segmentation models is thoroughly detailed. The method is tested on segmentation of five object classes in MATLAS images. We find that unifying the tasks of galactic structure segmentation and contaminant segmentation improves model perfor-mance in comparison to isolating each task

Stratified decision forests for accurate anatomical landmark localization in cardiac images

Accurate localization of anatomical landmarks is an important step in medical imaging, as it provides useful prior information for subsequent image analysis and acquisition methods. It is particularly useful for initialization of automatic image analysis tools (e.g. segmentation and registration) and detection of scan planes for automated image acquisition. Landmark localization has been commonly performed using learning based approaches, such as classifier and/or regressor models. However, trained models may not generalize well in heterogeneous datasets when the images contain large differences due to size, pose and shape variations of organs. To learn more data-adaptive and patient specific models, we propose a novel stratification based training model, and demonstrate its use in a decision forest. The proposed approach does not require any additional training information compared to the standard model training procedure and can be easily integrated into any decision tree framework. The proposed method is evaluated on 1080 3D highresolution and 90 multi-stack 2D cardiac cine MR images. The experiments show that the proposed method achieves state-of-theart landmark localization accuracy and outperforms standard regression and classification based approaches. Additionally, the proposed method is used in a multi-atlas segmentation to create a fully automatic segmentation pipeline, and the results show that it achieves state-of-the-art segmentation accuracy

A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation

Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the contents of cellular tomograms are often complex, making it difficult to automatically isolate different in situ cellular components. In this paper, we propose a convolutional autoencoder-based unsupervised approach to provide a coarse grouping of 3D small subvolumes extracted from tomograms. We demonstrate that the autoencoder can be used for efficient and coarse characterization of features of macromolecular complexes and surfaces, such as membranes. In addition, the autoencoder can be used to detect non-cellular features related to sample preparation and data collection, such as carbon edges from the grid and tomogram boundaries. The autoencoder is also able to detect patterns that may indicate spatial interactions between cellular components. Furthermore, we demonstrate that our autoencoder can be used for weakly supervised semantic segmentation of cellular components, requiring a very small amount of manual annotation.Comment: Accepted by Journal of Structural Biolog

Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images

We propose a novel attention gate (AG) model for medical image analysis that automatically learns to focus on target structures of varying shapes and sizes. Models trained with AGs implicitly learn to suppress irrelevant regions in an input image while highlighting salient features useful for a specific task. This enables us to eliminate the necessity of using explicit external tissue/organ localisation modules when using convolutional neural networks (CNNs). AGs can be easily integrated into standard CNN models such as VGG or U-Net architectures with minimal computational overhead while increasing the model sensitivity and prediction accuracy. The proposed AG models are evaluated on a variety of tasks, including medical image classification and segmentation. For classification, we demonstrate the use case of AGs in scan plane detection for fetal ultrasound screening. We show that the proposed attention mechanism can provide efficient object localisation while improving the overall prediction performance by reducing false positives. For segmentation, the proposed architecture is evaluated on two large 3D CT abdominal datasets with manual annotations for multiple organs. Experimental results show that AG models consistently improve the prediction performance of the base architectures across different datasets and training sizes while preserving computational efficiency. Moreover, AGs guide the model activations to be focused around salient regions, which provides better insights into how model predictions are made. The source code for the proposed AG models is publicly available.Comment: Accepted for Medical Image Analysis (Special Issue on Medical Imaging with Deep Learning). arXiv admin note: substantial text overlap with arXiv:1804.03999, arXiv:1804.0533