Factors affecting speech intelligibility improvement with exposure to reverberant room listening environments.

Speech intelligibility has been found to improve with prior exposure to a reverberant room environment. It is believed that perceptual mechanisms help maintain accurate speech perception under these adverse conditions. Potential factors underlying this speech enhancement effect were examined in three experiments. Experiment 1 studied the time course of speech intelligibility enhancement in multiple room environments. Carrier phrases of varying lengths were used to measure changes in speech intelligibility over time. Results showed an effect of speech enhancement with a time course that varied with the signal-to-noise ratio between the speech and a broad-band noise masker. Additionally, greater speech enhancement was found for reverberant environments compared to anechoic space, which suggests that a de-reverberation mechanism in the auditory system may enhance the temporal processing of speech. Experiment 2 examined the influence of the specific source and listener position within the room environment on speech enhancement. Source and listener configurations in three virtual room environments were altered to create a disparity between the position of a carrier phrase and a following speech target. Results showed robust effects of speech enhancement when the source and listener configuration were mismatched which suggests that speech enhancement relies on the general decay pattern of the room environment and not the specific temporal/spatial configuration of early reflections. Experiment 3 assessed the relationships between room-associated speech enhancement and single-reflection echo suppression by measuring echo thresholds for both a traditional click-based stimuli and with speech materials. Echo thresholds were found to be uncorrelated with the results of Experiment I. This suggests that early reflections have little impact on the de-reverberation aspect of speech enhancement, which is consistent with the results from Experiment II. A two-process hypothesis is proposed to account for the results of these experiments as well as previous research on this topic. Prior exposure to a speech pattern provided via carrier phrases is argued to elicit improved temporal processing of speech that results in speech enhancement. It is also argued that a process of de-reverberation effectively reduces the attenuation of temporal information in room environments

Effect of Reverberation Context on Spatial Hearing Performance of Normally Hearing Listeners

Previous studies provide evidence that listening experience in a particular reverberant environment improves speech intelligibility and localization performance in that environment. Such studies, however, are few, and there is little knowledge of the underlying mechanisms. The experiments presented in this thesis explored the effect of reverberation context, in particular, the similarity in interaural coherence within a context, on listeners\u27 performance in sound localization, speech perception in a spatially separated noise, spatial release from speech-on-speech masking, and target location identification in a multi-talker configuration. All experiments were conducted in simulated reverberant environments created with a loudspeaker array in an anechoic chamber. The reflections comprising the reverberation in each environment had the same temporal and relative amplitude patterns, but varied in their lateral spread, which affected the interaural coherence of reverberated stimuli. The effect of reverberation context was examined by comparing performance in two reverberation contexts, mixed and fixed. In the mixed context, the reverberation environment applied to each stimulus varied trial-by-trial, whereas in the fixed context, the reverberation environment was held constant within a block of trials. In Experiment I (absolute judgement of sound location), variability in azimuth judgments was lower in the fixed than in the mixed context, suggesting that sound localization depended not only on the cues presented in isolated trials. In Experiment II, the intelligibility of speech in a spatially separated noise was found to be similar in both reverberation contexts. That result contrasts with other studies, and suggests that the fixed context did not assist listeners in compensating for degraded interaural coherence. In Experiment III, speech intelligibility in multi-talker configurations was found to be better in the fixed context, but only when the talkers were separated. That is, the fixed context improved spatial release from masking. However, in the presence of speech maskers, consistent reverberation did not improve the localizability of the target talker in a three-alternative location-identification task. Those results suggest that in multi-talker situations, consistent coherence may not improve target localizability, but rather that consistent context may facilitate the buildup of spatial selective attention

Exploring the use of speech in audiology: A mixed methods study

This thesis aims to advance the understanding of how speech testing is, and can be, used for hearing device users within the audiological test battery. To address this, I engaged with clinicians and patients to understand the current role that speech testing plays in audiological testing in the UK, and developed a new listening test, which combined speech testing with localisation judgments in a dual task design. Normal hearing listeners and hearing aid users were tested, and a series of technical measurements were made to understand how advanced hearing aid settings might determine task performance. A questionnaire was completed by public and private sector hearing healthcare professionals in the UK to explore the use of speech testing. Overall, results revealed this assessment tool was underutilised by UK clinicians, but there was a significantly greater use in the private sector. Through a focus group and semi structured interviews with hearing aid users I identified a mismatch between their common listening difficulties and the assessment tools used in audiology and highlighted a lack of deaf awareness in UK adult audiology. The Spatial Speech in Noise Test (SSiN) is a dual task paradigm to simultaneously assess relative localisation and word identification performance. Testing on normal hearing listeners to investigate the impact of the dual task design found the SSiN to increase cognitive load and therefore better reflect challenging listening situations. A comparison of relative localisation and word identification performance showed that hearing aid users benefitted less from spatially separating speech and noise in the SSiN than normal hearing listeners. To investigate how the SSiN could be used to assess advanced hearing aid features, a subset of hearing aid users were fitted with the same hearing aid type and completed the SSiN once with adaptive directionality and once with omnidirectionality. The SSiN results differed between conditions but a larger sample size is needed to confirm these effects. Hearing aid technical measurements were used to quantify how hearing aid output changed in response to the SSiN paradigm

The use of acoustic cues in phonetic perception: Effects of spectral degradation, limited bandwidth and background noise

Hearing impairment, cochlear implantation, background noise and other auditory degradations result in the loss or distortion of sound information thought to be critical to speech perception. In many cases, listeners can still identify speech sounds despite degradations, but understanding of how this is accomplished is incomplete. Experiments presented here tested the hypothesis that listeners would utilize acoustic-phonetic cues differently if one or more cues were degraded by hearing impairment or simulated hearing impairment. Results supported this hypothesis for various listening conditions that are directly relevant for clinical populations. Analysis included mixed-effects logistic modeling of contributions of individual acoustic cues for various contrasts. Listeners with cochlear implants (CIs) or normal-hearing (NH) listeners in CI simulations showed increased use of acoustic cues in the temporal domain and decreased use of cues in the spectral domain for the tense/lax vowel contrast and the word-final fricative voicing contrast. For the word-initial stop voicing contrast, NH listeners made less use of voice-onset time and greater use of voice pitch in conditions that simulated high-frequency hearing impairment and/or masking noise; influence of these cues was further modulated by consonant place of articulation. A pair of experiments measured phonetic context effects for the "s/sh" contrast, replicating previously observed effects for NH listeners and generalizing them to CI listeners as well, despite known deficiencies in spectral resolution for CI listeners. For NH listeners in CI simulations, these context effects were absent or negligible. Audio-visual delivery of this experiment revealed enhanced influence of visual lip-rounding cues for CI listeners and NH listeners in CI simulations. Additionally, CI listeners demonstrated that visual cues to gender influence phonetic perception in a manner consistent with gender-related voice acoustics. All of these results suggest that listeners are able to accommodate challenging listening situations by capitalizing on the natural (multimodal) covariance in speech signals. Additionally, these results imply that there are potential differences in speech perception by NH listeners and listeners with hearing impairment that would be overlooked by traditional word recognition or consonant confusion matrix analysis

Spatial release of masking in children and adults in non-individualized virtual environments

The spatial release of masking (SRM) is often measured in virtual auditory environments created from head-related transfer functions (HRTFs) of a standardized adult head. Adults and children, however, differ in head dimensions and mismatched HRTFs are known to affect some aspects of binaural hearing. So far, there has been little research on HRTFs in children and it is unclear whether a large mismatch of spatial cues can degrade speech perception in complex environments. In two studies, the effect of non-individualized virtual environments on SRM accuracy in adults and children was examined. The SRMs were measured in virtual environments created from individual and non-individualized HRTFs and the equivalent real anechoic environment. Speech reception thresholds (SRTs) were measured for frontal target sentences and symmetrical speech maskers at 0° or ±90° azimuth. No significant difference between environments was observed for adults. In 7 to 12-year-old children, SRTs and SRMs improved with age, with SRMs approaching adult levels. SRTs differed slightly between environments and were significantly worse in a virtual environment based on HRTFs from a spherical head. Adult HRTFs seem sufficient to accurately measure SRTs in children even in complex listening conditions

The influence of channel and source degradations on intelligibility and physiological measurements of effort

Despite the fact that everyday listening is compromised by acoustic degradations, individuals show a remarkable ability to understand degraded speech. However, recent trends in speech perception research emphasise the cognitive load imposed by degraded speech on both normal-hearing and hearing-impaired listeners. The perception of degraded speech is often studied through channel degradations such as background noise. However, source degradations determined by talkers’ acoustic-phonetic characteristics have been studied to a lesser extent, especially in the context of listening effort models. Similarly, little attention has been given to speaking effort, i.e., effort experienced by talkers when producing speech under channel degradations. This thesis aims to provide a holistic understanding of communication effort, i.e., taking into account both listener and talker factors. Three pupillometry studies are presented. In the first study, speech was recorded for 16 Southern British English speakers and presented to normal-hearing listeners in quiet and in combination with three degradations: noise-vocoding, masking and time-compression. Results showed that acoustic-phonetic talker characteristics predicted intelligibility of degraded speech, but not listening effort, as likely indexed by pupil dilation. In the second study, older hearing-impaired listeners were presented fast time-compressed speech under simulated room acoustics. Intelligibility was kept at high levels. Results showed that both fast speech and reverberant speech were associated with higher listening effort, as suggested by pupillometry. Discrepancies between pupillometry and perceived effort ratings suggest that both methods should be employed in speech perception research to pinpoint processing effort. While findings from the first two studies support models of degraded speech perception, emphasising the relevance of source degradations, they also have methodological implications for pupillometry paradigms. In the third study, pupillometry was combined with a speech production task, aiming to establish an equivalent to listening effort for talkers: speaking effort. Normal-hearing participants were asked to read and produce speech in quiet or in the presence of different types of masking: stationary and modulated speech-shaped noise, and competing-talker masking. Results indicated that while talkers acoustically enhance their speech more under stationary masking, larger pupil dilation associated with competing-speaker masking reflected higher speaking effort. Results from all three studies are discussed in conjunction with models of degraded speech perception and production. Listening effort models are revisited to incorporate pupillometry results from speech production paradigms. Given the new approach of investigating source factors using pupillometry, methodological issues are discussed as well. The main insight provided by this thesis, i.e., the feasibility of applying pupillometry to situations involving listener and talker factors, is suggested to guide future research employing naturalistic conversations

Ultra-high-speed imaging of bubbles interacting with cells and tissue

Ultrasound contrast microbubbles are exploited in molecular imaging, where bubbles are directed to target cells and where their high-scattering cross section to ultrasound allows for the detection of pathologies at a molecular level. In therapeutic applications vibrating bubbles close to cells may alter the permeability of cell membranes, and these systems are therefore highly interesting for drug and gene delivery applications using ultrasound. In a more extreme regime bubbles are driven through shock waves to sonoporate or kill cells through intense stresses or jets following inertial bubble collapse. Here, we elucidate some of the underlying mechanisms using the 25-Mfps camera Brandaris128, resolving the bubble dynamics and its interactions with cells. We quantify acoustic microstreaming around oscillating bubbles close to rigid walls and evaluate the shear stresses on nonadherent cells. In a study on the fluid dynamical interaction of cavitation bubbles with adherent cells, we find that the nonspherical collapse of bubbles is responsible for cell detachment. We also visualized the dynamics of vibrating microbubbles in contact with endothelial cells followed by fluorescent imaging of the transport of propidium iodide, used as a membrane integrity probe, into these cells showing a direct correlation between cell deformation and cell membrane permeability

Temporal contrast effects in human speech perception are immune to selective attention

Two fundamental properties of perception are selective attention and perceptual contrast, but how these two processes interact remains unknown. Does an attended stimulus history exert a larger contrastive influence on the perception of a following target than unattended stimuli? Dutch listeners categorized target sounds with a reduced prefix "ge-" marking tense (e.g., ambiguous between gegaan-gaan "gone-go"). In 'single talker' Experiments 1-2, participants perceived the reduced syllable (reporting gegaan) when the target was heard after a fast sentence, but not after a slow sentence (reporting gaan). In 'selective attention' Experiments 3-5, participants listened to two simultaneous sentences from two different talkers, followed by the same target sounds, with instructions to attend only one of the two talkers. Critically, the speech rates of attended and unattended talkers were found to equally influence target perception - even when participants could watch the attended talker speak. In fact, participants' target perception in 'selective attention' Experiments 3-5 did not differ from participants who were explicitly instructed to divide their attention equally across the two talkers (Experiment 6). This suggests that contrast effects of speech rate are immune to selective attention, largely operating prior to attentional stream segregation in the auditory processing hierarchy