31,243 research outputs found
Anytime Hierarchical Clustering
We propose a new anytime hierarchical clustering method that iteratively
transforms an arbitrary initial hierarchy on the configuration of measurements
along a sequence of trees we prove for a fixed data set must terminate in a
chain of nested partitions that satisfies a natural homogeneity requirement.
Each recursive step re-edits the tree so as to improve a local measure of
cluster homogeneity that is compatible with a number of commonly used (e.g.,
single, average, complete) linkage functions. As an alternative to the standard
batch algorithms, we present numerical evidence to suggest that appropriate
adaptations of this method can yield decentralized, scalable algorithms
suitable for distributed/parallel computation of clustering hierarchies and
online tracking of clustering trees applicable to large, dynamically changing
databases and anomaly detection.Comment: 13 pages, 6 figures, 5 tables, in preparation for submission to a
conferenc
Learning the optimal scale for GWAS through hierarchical SNP aggregation
Motivation: Genome-Wide Association Studies (GWAS) seek to identify causal
genomic variants associated with rare human diseases. The classical statistical
approach for detecting these variants is based on univariate hypothesis
testing, with healthy individuals being tested against affected individuals at
each locus. Given that an individual's genotype is characterized by up to one
million SNPs, this approach lacks precision, since it may yield a large number
of false positives that can lead to erroneous conclusions about genetic
associations with the disease. One way to improve the detection of true genetic
associations is to reduce the number of hypotheses to be tested by grouping
SNPs. Results: We propose a dimension-reduction approach which can be applied
in the context of GWAS by making use of the haplotype structure of the human
genome. We compare our method with standard univariate and multivariate
approaches on both synthetic and real GWAS data, and we show that reducing the
dimension of the predictor matrix by aggregating SNPs gives a greater precision
in the detection of associations between the phenotype and genomic regions
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