Chaotic Signatures of Heart Rate Variability and Its Power Spectrum in Health, Aging and Heart Failure

A paradox regarding the classic power spectral analysis of heart rate variability (HRV) is whether the characteristic high- (HF) and low-frequency (LF) spectral peaks represent stochastic or chaotic phenomena. Resolution of this fundamental issue is key to unraveling the mechanisms of HRV, which is critical to its proper use as a noninvasive marker for cardiac mortality risk assessment and stratification in congestive heart failure (CHF) and other cardiac dysfunctions. However, conventional techniques of nonlinear time series analysis generally lack sufficient sensitivity, specificity and robustness to discriminate chaos from random noise, much less quantify the chaos level. Here, we apply a ‘litmus test’ for heartbeat chaos based on a novel noise titration assay which affords a robust, specific, time-resolved and quantitative measure of the relative chaos level. Noise titration of running short-segment Holter tachograms from healthy subjects revealed circadian-dependent (or sleep/wake-dependent) heartbeat chaos that was linked to the HF component (respiratory sinus arrhythmia). The relative ‘HF chaos’ levels were similar in young and elderly subjects despite proportional age-related decreases in HF and LF power. In contrast, the near-regular heartbeat in CHF patients was primarily nonchaotic except punctuated by undetected ectopic beats and other abnormal beats, causing transient chaos. Such profound circadian-, age- and CHF-dependent changes in the chaotic and spectral characteristics of HRV were accompanied by little changes in approximate entropy, a measure of signal irregularity. The salient chaotic signatures of HRV in these subject groups reveal distinct autonomic, cardiac, respiratory and circadian/sleep-wake mechanisms that distinguish health and aging from CHF

The frequency architecture of brain and brain body oscillations : an analysis

Research on brain oscillations has brought up a picture of coupled oscillators. Some of the most important questions that will be analyzed are, how many frequencies are there, what are the coupling principles, what their functional meaning is, and whether body oscillations follow similar coupling principles. It is argued that physiologically, two basic coupling principles govern brain as well as body oscillations: (i) amplitude (envelope) modulation between any frequencies m and n, where the phase of the slower frequency m modulates the envelope of the faster frequency n, and (ii) phase coupling between m and n, where the frequency of n is a harmonic multiple of m. An analysis of the center frequency of traditional frequency bands and their coupling principles suggest a binary hierarchy of frequencies. This principle leads to the foundation of the binary hierarchy brain body oscillation theory. Its central hypotheses are that the frequencies of body oscillations can be predicted from brain oscillations and that brain and body oscillations are aligned to each other. The empirical evaluation of the predicted frequencies for body oscillations is discussed on the basis of findings for heart rate, heart rate variability, breathing frequencies, fluctuations in the BOLD signal, and other body oscillations. The conclusion is that brain and many body oscillations can be described by a single system, where the cross talk reflecting communication within and between brain and body oscillations is governed by m : n phase to envelope and phase to phase coupling.(VLID)310650