1,191 research outputs found
Global consensus Monte Carlo
To conduct Bayesian inference with large data sets, it is often convenient or
necessary to distribute the data across multiple machines. We consider a
likelihood function expressed as a product of terms, each associated with a
subset of the data. Inspired by global variable consensus optimisation, we
introduce an instrumental hierarchical model associating auxiliary statistical
parameters with each term, which are conditionally independent given the
top-level parameters. One of these top-level parameters controls the
unconditional strength of association between the auxiliary parameters. This
model leads to a distributed MCMC algorithm on an extended state space yielding
approximations of posterior expectations. A trade-off between computational
tractability and fidelity to the original model can be controlled by changing
the association strength in the instrumental model. We further propose the use
of a SMC sampler with a sequence of association strengths, allowing both the
automatic determination of appropriate strengths and for a bias correction
technique to be applied. In contrast to similar distributed Monte Carlo
algorithms, this approach requires few distributional assumptions. The
performance of the algorithms is illustrated with a number of simulated
examples
Challenges of Big Data Analysis
Big Data bring new opportunities to modern society and challenges to data
scientists. On one hand, Big Data hold great promises for discovering subtle
population patterns and heterogeneities that are not possible with small-scale
data. On the other hand, the massive sample size and high dimensionality of Big
Data introduce unique computational and statistical challenges, including
scalability and storage bottleneck, noise accumulation, spurious correlation,
incidental endogeneity, and measurement errors. These challenges are
distinguished and require new computational and statistical paradigm. This
article give overviews on the salient features of Big Data and how these
features impact on paradigm change on statistical and computational methods as
well as computing architectures. We also provide various new perspectives on
the Big Data analysis and computation. In particular, we emphasis on the
viability of the sparsest solution in high-confidence set and point out that
exogeneous assumptions in most statistical methods for Big Data can not be
validated due to incidental endogeneity. They can lead to wrong statistical
inferences and consequently wrong scientific conclusions
A Survey of Bayesian Statistical Approaches for Big Data
The modern era is characterised as an era of information or Big Data. This
has motivated a huge literature on new methods for extracting information and
insights from these data. A natural question is how these approaches differ
from those that were available prior to the advent of Big Data. We present a
review of published studies that present Bayesian statistical approaches
specifically for Big Data and discuss the reported and perceived benefits of
these approaches. We conclude by addressing the question of whether focusing
only on improving computational algorithms and infrastructure will be enough to
face the challenges of Big Data
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
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