Learning signals of adverse drug-drug interactions from the unstructured text of electronic health records.

Drug-drug interactions (DDI) account for 30% of all adverse drug reactions, which are the fourth leading cause of death in the US. Current methods for post marketing surveillance primarily use spontaneous reporting systems for learning DDI signals and validate their signals using the structured portions of Electronic Health Records (EHRs). We demonstrate a fast, annotation-based approach, which uses standard odds ratios for identifying signals of DDIs from the textual portion of EHRs directly and which, to our knowledge, is the first effort of its kind. We developed a gold standard of 1,120 DDIs spanning 14 adverse events and 1,164 drugs. Our evaluations on this gold standard using millions of clinical notes from the Stanford Hospital confirm that identifying DDI signals from clinical text is feasible (AUROC=81.5%). We conclude that the text in EHRs contain valuable information for learning DDI signals and has enormous utility in drug surveillance and clinical decision support

When Things Matter: A Data-Centric View of the Internet of Things

With the recent advances in radio-frequency identification (RFID), low-cost wireless sensor devices, and Web technologies, the Internet of Things (IoT) approach has gained momentum in connecting everyday objects to the Internet and facilitating machine-to-human and machine-to-machine communication with the physical world. While IoT offers the capability to connect and integrate both digital and physical entities, enabling a whole new class of applications and services, several significant challenges need to be addressed before these applications and services can be fully realized. A fundamental challenge centers around managing IoT data, typically produced in dynamic and volatile environments, which is not only extremely large in scale and volume, but also noisy, and continuous. This article surveys the main techniques and state-of-the-art research efforts in IoT from data-centric perspectives, including data stream processing, data storage models, complex event processing, and searching in IoT. Open research issues for IoT data management are also discussed

Ontologies and Bigram-based approach for Isolated Non-word Errors Correction in OCR System

In this paper, we describe a new and original approach for post-processing step in an OCR system. This approach is based on new method of spelling correction to correct automatically misspelled words resulting from a character recognition step of scanned documents by combining both ontologies and bigram code in order to create a robust system able to solve automatically the anomalies of classical approaches. The proposed approach is based on a hybrid method which is spread over two stages, first one is character recognition by using the ontological model and the second one is word recognition based on spelling correction approach based on bigram codification for detection and correction of errors. The spelling error is broadly classified in two categories namely non-word error and real-word error. In this paper, we interested only on detection and correction of non-word errors because this is the only type of errors treated by an OCR. In addition, the use of an online external resource such as WordNet proves necessary to improve its performances

Analysis of Internet of Things (IOT) ecosystem from the perspective of device functionality, application security and application accessibility, An

2022 Spring.Includes bibliographical references.Internet of Thing (IoT) devices are being widely used in smart homes and organizations. IoT devices can have security vulnerabilities in different fronts: Device front with embedded functionalities and Application front. This work aims to analyze IoT devices security health from device functionality perspective and application security and accessibility perspective to understand holistic picture of entire IoT ecosystem's security health. An IoT device has some intended purposes, but may also have hidden functionalities. Typically, the device is installed in a home or an organization and the network traffic associated with the device is captured and analyzed to infer high-level functionality to the extent possible. However, such analysis is dynamic in nature, and requires the installation of the device and access to network data which is often hard to get for privacy and confidentiality reasons. In this work, we propose an alternative static approach which can infer the functionality of a device from vendor materials using Natural Language Processing (NLP) techniques. Information about IoT device functionality can be used in various applications, one of which is ensuring security in a smart home. We can also use the device functionalities in various security applications especially access control policies. Based on the functionality of a device we can provide assurance to the consumer that these devices will be compliant to the home or organizational policy even before they have been purchased. Most IoT devices interface with the user through mobile companion apps. Such apps are used to configure, update, and control the device(s) constituting a critical component in the IoT ecosystem, but they have historically been under-studied. In this thesis, we also perform security and accessibility analysis of IoT application on 265 apps to understand security and accessibility vulnerabilities present in the apps and identify some mitigating strategies

Inferring Complex Activities for Context-aware Systems within Smart Environments

The rising ageing population worldwide and the prevalence of age-related conditions such as physical fragility, mental impairments and chronic diseases have significantly impacted the quality of life and caused a shortage of health and care services. Over-stretched healthcare providers are leading to a paradigm shift in public healthcare provisioning. Thus, Ambient Assisted Living (AAL) using Smart Homes (SH) technologies has been rigorously investigated to help address the aforementioned problems. Human Activity Recognition (HAR) is a critical component in AAL systems which enables applications such as just-in-time assistance, behaviour analysis, anomalies detection and emergency notifications. This thesis is aimed at investigating challenges faced in accurately recognising Activities of Daily Living (ADLs) performed by single or multiple inhabitants within smart environments. Specifically, this thesis explores five complementary research challenges in HAR. The first study contributes to knowledge by developing a semantic-enabled data segmentation approach with user-preferences. The second study takes the segmented set of sensor data to investigate and recognise human ADLs at multi-granular action level; coarse- and fine-grained action level. At the coarse-grained actions level, semantic relationships between the sensor, object and ADLs are deduced, whereas, at fine-grained action level, object usage at the satisfactory threshold with the evidence fused from multimodal sensor data is leveraged to verify the intended actions. Moreover, due to imprecise/vague interpretations of multimodal sensors and data fusion challenges, fuzzy set theory and fuzzy web ontology language (fuzzy-OWL) are leveraged. The third study focuses on incorporating uncertainties caused in HAR due to factors such as technological failure, object malfunction, and human errors. Hence, existing studies uncertainty theories and approaches are analysed and based on the findings, probabilistic ontology (PR-OWL) based HAR approach is proposed. The fourth study extends the first three studies to distinguish activities conducted by more than one inhabitant in a shared smart environment with the use of discriminative sensor-based techniques and time-series pattern analysis. The final study investigates in a suitable system architecture with a real-time smart environment tailored to AAL system and proposes microservices architecture with sensor-based off-the-shelf and bespoke sensing methods. The initial semantic-enabled data segmentation study was evaluated with 100% and 97.8% accuracy to segment sensor events under single and mixed activities scenarios. However, the average classification time taken to segment each sensor events have suffered from 3971ms and 62183ms for single and mixed activities scenarios, respectively. The second study to detect fine-grained-level user actions was evaluated with 30 and 153 fuzzy rules to detect two fine-grained movements with a pre-collected dataset from the real-time smart environment. The result of the second study indicate good average accuracy of 83.33% and 100% but with the high average duration of 24648ms and 105318ms, and posing further challenges for the scalability of fusion rule creations. The third study was evaluated by incorporating PR-OWL ontology with ADL ontologies and Semantic-Sensor-Network (SSN) ontology to define four types of uncertainties presented in the kitchen-based activity. The fourth study illustrated a case study to extended single-user AR to multi-user AR by combining RFID tags and fingerprint sensors discriminative sensors to identify and associate user actions with the aid of time-series analysis. The last study responds to the computations and performance requirements for the four studies by analysing and proposing microservices-based system architecture for AAL system. A future research investigation towards adopting fog/edge computing paradigms from cloud computing is discussed for higher availability, reduced network traffic/energy, cost, and creating a decentralised system. As a result of the five studies, this thesis develops a knowledge-driven framework to estimate and recognise multi-user activities at fine-grained level user actions. This framework integrates three complementary ontologies to conceptualise factual, fuzzy and uncertainties in the environment/ADLs, time-series analysis and discriminative sensing environment. Moreover, a distributed software architecture, multimodal sensor-based hardware prototypes, and other supportive utility tools such as simulator and synthetic ADL data generator for the experimentation were developed to support the evaluation of the proposed approaches. The distributed system is platform-independent and currently supported by an Android mobile application and web-browser based client interfaces for retrieving information such as live sensor events and HAR results

Rationale in Development Chat Messages: An Exploratory Study

Chat messages of development teams play an increasingly significant role in software development, having replaced emails in some cases. Chat messages contain information about discussed issues, considered alternatives and argumentation leading to the decisions made during software development. These elements, defined as rationale, are invaluable during software evolution for documenting and reusing development knowledge. Rationale is also essential for coping with changes and for effective maintenance of the software system. However, exploiting the rationale hidden in the chat messages is challenging due to the high volume of unstructured messages covering a wide range of topics. This work presents the results of an exploratory study examining the frequency of rationale in chat messages, the completeness of the available rationale and the potential of automatic techniques for rationale extraction. For this purpose, we apply content analysis and machine learning techniques on more than 8,700 chat messages from three software development projects. Our results show that chat messages are a rich source of rationale and that machine learning is a promising technique for detecting rationale and identifying different rationale elements.Comment: 11 pages, 6 figures. The 14th International Conference on Mining Software Repositories (MSR'17

Exploring The Responsibilities Of Single-Inhabitant Smart Homes With Use Cases

DOI: 10.3233/AIS-2010-0076This paper makes a number of contributions to the field of requirements analysis for Smart Homes. It introduces Use Cases as a tool for exploring the responsibilities of Smart Homes and it proposes a modification of the conventional Use Case structure to suit the particular requirements of Smart Homes. It presents a taxonomy of Smart-Home-related Use Cases with seven categories. It draws on those Use Cases as raw material for developing questions and conclusions about the design of Smart Homes for single elderly inhabitants, and it introduces the SHMUC repository, a web-based repository of Use Cases related to Smart Homes that anyone can exploit and to which anyone may contribute

Contextual Recommendations using Intention Mining on Process Traces

International audienceNowadays, digital traces are omnipresent in Information System (IS). Companies track IS interactions to retrieve and compile information about actors. Researchers of various streams, within IT and beyond, focused on recording actor interactions with systems and the technical possibilities to identify record and store these interactions. Tracing functionality has appeared in almost all common computer applications. This PhD project will focus on the establishment of a trace-based system and propose recommendations to actors regarding to their context. The objective of this thesis is to study process traces to propose recommendations to the actors by identifying a set of generic processes adaptable to the current actors' context. Thus, any actor, expert or novice, will be able to use this knowledge that gives contextual clues to identify the potential steps he could perform