8,507 research outputs found
Generative Invertible Networks (GIN): Pathophysiology-Interpretable Feature Mapping and Virtual Patient Generation
Machine learning methods play increasingly important roles in pre-procedural
planning for complex surgeries and interventions. Very often, however,
researchers find the historical records of emerging surgical techniques, such
as the transcatheter aortic valve replacement (TAVR), are highly scarce in
quantity. In this paper, we address this challenge by proposing novel
generative invertible networks (GIN) to select features and generate
high-quality virtual patients that may potentially serve as an additional data
source for machine learning. Combining a convolutional neural network (CNN) and
generative adversarial networks (GAN), GIN discovers the pathophysiologic
meaning of the feature space. Moreover, a test of predicting the surgical
outcome directly using the selected features results in a high accuracy of
81.55%, which suggests little pathophysiologic information has been lost while
conducting the feature selection. This demonstrates GIN can generate virtual
patients not only visually authentic but also pathophysiologically
interpretable
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Prediction of progression in idiopathic pulmonary fibrosis using CT scans atbaseline: A quantum particle swarm optimization - Random forest approach
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by an unpredictable progressive declinein lung function. Natural history of IPF is unknown and the prediction of disease progression at the time ofdiagnosis is notoriously difficult. High resolution computed tomography (HRCT) has been used for the diagnosisof IPF, but not generally for monitoring purpose. The objective of this work is to develop a novel predictivemodel for the radiological progression pattern at voxel-wise level using only baseline HRCT scans. Mainly, thereare two challenges: (a) obtaining a data set of features for region of interest (ROI) on baseline HRCT scans andtheir follow-up status; and (b) simultaneously selecting important features from high-dimensional space, andoptimizing the prediction performance. We resolved the first challenge by implementing a study design andhaving an expert radiologist contour ROIs at baseline scans, depending on its progression status in follow-upvisits. For the second challenge, we integrated the feature selection with prediction by developing an algorithmusing a wrapper method that combines quantum particle swarm optimization to select a small number of featureswith random forest to classify early patterns of progression. We applied our proposed algorithm to analyzeanonymized HRCT images from 50 IPF subjects from a multi-center clinical trial. We showed that it yields aparsimonious model with 81.8% sensitivity, 82.2% specificity and an overall accuracy rate of 82.1% at the ROIlevel. These results are superior to other popular feature selections and classification methods, in that ourmethod produces higher accuracy in prediction of progression and more balanced sensitivity and specificity witha smaller number of selected features. Our work is the first approach to show that it is possible to use onlybaseline HRCT scans to predict progressive ROIs at 6 months to 1year follow-ups using artificial intelligence
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