169 research outputs found
Deep Multi-instance Networks with Sparse Label Assignment for Whole Mammogram Classification
Mammogram classification is directly related to computer-aided diagnosis of
breast cancer. Traditional methods rely on regions of interest (ROIs) which
require great efforts to annotate. Inspired by the success of using deep
convolutional features for natural image analysis and multi-instance learning
(MIL) for labeling a set of instances/patches, we propose end-to-end trained
deep multi-instance networks for mass classification based on whole mammogram
without the aforementioned ROIs. We explore three different schemes to
construct deep multi-instance networks for whole mammogram classification.
Experimental results on the INbreast dataset demonstrate the robustness of
proposed networks compared to previous work using segmentation and detection
annotations.Comment: MICCAI 2017 Camera Read
Deep Learning for Automated Medical Image Analysis
Medical imaging is an essential tool in many areas of medical applications,
used for both diagnosis and treatment. However, reading medical images and
making diagnosis or treatment recommendations require specially trained medical
specialists. The current practice of reading medical images is labor-intensive,
time-consuming, costly, and error-prone. It would be more desirable to have a
computer-aided system that can automatically make diagnosis and treatment
recommendations. Recent advances in deep learning enable us to rethink the ways
of clinician diagnosis based on medical images. In this thesis, we will
introduce 1) mammograms for detecting breast cancers, the most frequently
diagnosed solid cancer for U.S. women, 2) lung CT images for detecting lung
cancers, the most frequently diagnosed malignant cancer, and 3) head and neck
CT images for automated delineation of organs at risk in radiotherapy. First,
we will show how to employ the adversarial concept to generate the hard
examples improving mammogram mass segmentation. Second, we will demonstrate how
to use the weakly labeled data for the mammogram breast cancer diagnosis by
efficiently design deep learning for multi-instance learning. Third, the thesis
will walk through DeepLung system which combines deep 3D ConvNets and GBM for
automated lung nodule detection and classification. Fourth, we will show how to
use weakly labeled data to improve existing lung nodule detection system by
integrating deep learning with a probabilistic graphic model. Lastly, we will
demonstrate the AnatomyNet which is thousands of times faster and more accurate
than previous methods on automated anatomy segmentation.Comment: PhD Thesi
Adversarial Deep Structured Nets for Mass Segmentation from Mammograms
Mass segmentation provides effective morphological features which are
important for mass diagnosis. In this work, we propose a novel end-to-end
network for mammographic mass segmentation which employs a fully convolutional
network (FCN) to model a potential function, followed by a CRF to perform
structured learning. Because the mass distribution varies greatly with pixel
position, the FCN is combined with a position priori. Further, we employ
adversarial training to eliminate over-fitting due to the small sizes of
mammogram datasets. Multi-scale FCN is employed to improve the segmentation
performance. Experimental results on two public datasets, INbreast and
DDSM-BCRP, demonstrate that our end-to-end network achieves better performance
than state-of-the-art approaches.
\footnote{https://github.com/wentaozhu/adversarial-deep-structural-networks.git}Comment: Accepted by ISBI2018. arXiv admin note: substantial text overlap with
arXiv:1612.0597
Multi Scale Curriculum CNN for Context-Aware Breast MRI Malignancy Classification
Classification of malignancy for breast cancer and other cancer types is
usually tackled as an object detection problem: Individual lesions are first
localized and then classified with respect to malignancy. However, the drawback
of this approach is that abstract features incorporating several lesions and
areas that are not labelled as a lesion but contain global medically relevant
information are thus disregarded: especially for dynamic contrast-enhanced
breast MRI, criteria such as background parenchymal enhancement and location
within the breast are important for diagnosis and cannot be captured by object
detection approaches properly.
In this work, we propose a 3D CNN and a multi scale curriculum learning
strategy to classify malignancy globally based on an MRI of the whole breast.
Thus, the global context of the whole breast rather than individual lesions is
taken into account. Our proposed approach does not rely on lesion
segmentations, which renders the annotation of training data much more
effective than in current object detection approaches.
Achieving an AUROC of 0.89, we compare the performance of our approach to
Mask R-CNN and Retina U-Net as well as a radiologist. Our performance is on par
with approaches that, in contrast to our method, rely on pixelwise
segmentations of lesions.Comment: Accepted to MICCAI 201
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