Handling non-ignorable dropouts in longitudinal data: A conditional model based on a latent Markov heterogeneity structure

We illustrate a class of conditional models for the analysis of longitudinal data suffering attrition in random effects models framework, where the subject-specific random effects are assumed to be discrete and to follow a time-dependent latent process. The latent process accounts for unobserved heterogeneity and correlation between individuals in a dynamic fashion, and for dependence between the observed process and the missing data mechanism. Of particular interest is the case where the missing mechanism is non-ignorable. To deal with the topic we introduce a conditional to dropout model. A shape change in the random effects distribution is considered by directly modeling the effect of the missing data process on the evolution of the latent structure. To estimate the resulting model, we rely on the conditional maximum likelihood approach and for this aim we outline an EM algorithm. The proposal is illustrated via simulations and then applied on a dataset concerning skin cancers. Comparisons with other well-established methods are provided as well

A framework for clustering and adaptive topic tracking on evolving text and social media data streams.

Recent advances and widespread usage of online web services and social media platforms, coupled with ubiquitous low cost devices, mobile technologies, and increasing capacity of lower cost storage, has led to a proliferation of Big data, ranging from, news, e-commerce clickstreams, and online business transactions to continuous event logs and social media expressions. These large amounts of online data, often referred to as data streams, because they get generated at extremely high throughputs or velocity, can make conventional and classical data analytics methodologies obsolete. For these reasons, the issues of management and analysis of data streams have been researched extensively in recent years. The special case of social media Big Data brings additional challenges, particularly because of the unstructured nature of the data, specifically free text. One classical approach to mine text data has been Topic Modeling. Topic Models are statistical models that can be used for discovering the abstract ``topics\u27\u27 that may occur in a corpus of documents. Topic models have emerged as a powerful technique in machine learning and data science, providing a great balance between simplicity and complexity. They also provide sophisticated insight without the need for real natural language understanding. However they have not been designed to cope with the type of text data that is abundant on social media platforms, but rather for traditional medium size corpora consisting of longer documents, adhering to a specific language and typically spanning a stable set of topics. Unlike traditional document corpora, social media messages tend to be very short, sparse, noisy, and do not adhere to a standard vocabulary, linguistic patterns, or stable topic distributions. They are also generated at high velocity that impose high demands on topic modeling; and their evolving or dynamic nature, makes any set of results from topic modeling quickly become stale in the face of changes in the textual content and topics discussed within social media streams. In this dissertation, we propose an integrated topic modeling framework built on top of an existing stream-clustering framework called Stream-Dashboard, which can extract, isolate, and track topics over any given time period. In this new framework, Stream Dashboard first clusters the data stream points into homogeneous groups. Then data from each group is ushered to the topic modeling framework which extracts finer topics from the group. The proposed framework tracks the evolution of the clusters over time to detect milestones corresponding to changes in topic evolution, and to trigger an adaptation of the learned groups and topics at each milestone. The proposed approach to topic modeling is different from a generic Topic Modeling approach because it works in a compartmentalized fashion, where the input document stream is split into distinct compartments, and Topic Modeling is applied on each compartment separately. Furthermore, we propose extensions to existing topic modeling and stream clustering methods, including: an adaptive query reformulation approach to help focus on the topic discovery with time; a topic modeling extension with adaptive hyper-parameter and with infinite vocabulary; an adaptive stream clustering algorithm incorporating the automated estimation of dynamic, cluster-specific temporal scales for adaptive forgetting to help facilitate clustering in a fast evolving data stream. Our experimental results show that the proposed adaptive forgetting clustering algorithm can mine better quality clusters; that our proposed compartmentalized framework is able to mine topics of better quality compared to competitive baselines; and that the proposed framework can automatically adapt to focus on changing topics using the proposed query reformulation strategy

Synthetic Gene Circuits: Design with Directed Evolution

Synthetic circuits offer great promise for generating insights into nature's underlying design principles or forward engineering novel biotechnology applications. However, construction of these circuits is not straightforward. Synthetic circuits generally consist of components optimized to function in their natural context, not in the context of the synthetic circuit. Combining mathematical modeling with directed evolution offers one promising means for addressing this problem. Modeling identifies mutational targets and limits the evolutionary search space for directed evolution, which alters circuit performance without the need for detailed biophysical information. This review examines strategies for integrating modeling and directed evolution and discusses the utility and limitations of available methods

Report from GI-Dagstuhl Seminar 16394: Software Performance Engineering in the DevOps World

This report documents the program and the outcomes of GI-Dagstuhl Seminar 16394 "Software Performance Engineering in the DevOps World". The seminar addressed the problem of performance-aware DevOps. Both, DevOps and performance engineering have been growing trends over the past one to two years, in no small part due to the rise in importance of identifying performance anomalies in the operations (Ops) of cloud and big data systems and feeding these back to the development (Dev). However, so far, the research community has treated software engineering, performance engineering, and cloud computing mostly as individual research areas. We aimed to identify cross-community collaboration, and to set the path for long-lasting collaborations towards performance-aware DevOps. The main goal of the seminar was to bring together young researchers (PhD students in a later stage of their PhD, as well as PostDocs or Junior Professors) in the areas of (i) software engineering, (ii) performance engineering, and (iii) cloud computing and big data to present their current research projects, to exchange experience and expertise, to discuss research challenges, and to develop ideas for future collaborations