Peroxidase or Peroxygenase: the pH-Dependent Mechanism of Dehaloperoxidase

Undergraduate Basi

Vaidya Spacetime in Massive Gravity's Rainbow

In this paper, we will analyze the energy dependent deformation of massive gravity using the formalism of massive gravity's rainbow. So, we will use the Vainshtein mechanism and the dRGT mechanism for the energy dependent massive gravity, and thus analyze a ghost free theory of massive gravity's rainbow. We study the energy dependence of a time-dependent geometry, by analyzing the radiating Vaidya solution in this theory of massive gravity's rainbow. The energy dependent deformation of this Vaidya metric will be performed using suitable rainbow functions.Comment: 13 pages, 8 figure

Spin state readout by quantum jump technique: for the purpose of quantum computing

Utilizing the Pauli-blocking mechanism we show that shining circular polarized light on a singly-charged quantum dot induces spin dependent fluorescence. Employing the quantum-jump technique we demonstrate that this resonance luminescence, due to a spin dependent optical excitation, serves as an excellent readout mechanism for measuring the spin state of a single electron confined to a quantum dot.Comment: 11 pages, 4 eps figure

Liberating the Inflaton from Primordial Spectrum Constraints

I discuss a mechanism that renders the spectral index of the primordial spectrum and the inflationary stage independent of each other. If a scalar field acquires an appropriate time-dependent mass, it is possible to generate an adiabatic, Gaussian scale invariant spectrum of density perturbations during any stage of inflation. As an illustration, I present a simple model where the time-dependent mass arises from the coupling of the inflaton to a second scalar. The mechanism I propose might help to implement a successful inflationary scenario in particle physics theories that do not yield slow-roll potentials.Comment: 7 two-column pages, 1 figure. Uses RevTeX

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms. The DNA-binding dependent mechanism occurs by direct binding of GR to glucocorticoid response elements (GREs) at regulatory regions of target genes. The DNA-binding independent mechanism involves binding of GR to transcription factors and coactivators that, in turn, contact DNA. A small molecule that competes with GR for binding to GREs could be expected to affect the DNA-dependent pathway selectively by interfering with the protein-DNA interface. We show that a DNA-binding polyamide that targets the consensus GRE sequence binds the glucocorticoid-induced zipper (GILZ) GRE, inhibits expression of GILZ and several other known GR target genes, and reduces GR occupancy at the GILZ promoter. Genome-wide expression analysis of the effects of this polyamide on a set of glucocorticoid-induced and -repressed genes could help to elucidate the mechanism of GR regulation for these genes

How parametric resonance mechanism follows quench mechanism in disoriented chiral condensate

We show how parametric resonance mechanism follows quench mechanism in the classical linear sigma model. The parametric resonance amplifies long wavelength modes of the pion for more than $10 fm/c$. The shifting from the quench mechanism to the parametric resonance mechanism is described by a time dependent quantity. After the quench mechanism is over, that quantity has an oscillating part, which causes the parametric resonance. Since its frequency is $2 m_\pi ~(m_\pi$ : pion mass), very long wavelength modes such as k = 40 MeV of the pion are amplified by the parametric resonance.Comment: LaTeX, 10 page

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism.

Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient absorption through regulation of gastrointestinal motility. Smooth muscle-specific deletion and antibody blockade of α8 in mice result in enhanced gastric antral smooth muscle contraction, more rapid gastric emptying, and more rapid transit of food through the small intestine leading to malabsorption of dietary fats and carbohydrates as well as protection from weight gain in a diet-induced model of obesity. Mechanistically, ligation of α8β1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism. Collectively, our results identify a role for α8β1 in regulating gastrointestinal motility and identify α8 as a potential target for disorders characterized by hypo- or hyper-motility

Electronic conduction in multi-walled carbon nanotubes: Role of intershell coupling and incommensurability

Geometry incommensurability between weakly coupled shells in multi-walled carbon nanotubes is shown to be the origin of unconventional electronic conduction mechanism, power-law scaling of the conductance, and remarkable magnetotransport and low temperature dependent conductivity when the dephasing mechanism is dominated by weak electron-electron coupling