Dynamics of airflow in a short inhalation

During a rapid inhalation, such as a sniff, the flow in the airways accelerates and decays quickly. The consequences for flow development and convective trans- port of an inhaled gas were investigated in a subject geometry extending from the nose to the bronchi. The progress of flow transition and the advance of an inhaled non-absorbed gas were determined using highly resolved simulations of a sniff 0.5 s long, 1 litre per second peak flow, 364 ml inhaled volume. In the nose, the distribution of airflow evolved through three phases: (i) an initial transient of about 50 ms, roughly the filling time for a nasal volume, (ii) quasi-equilibrium over the majority of the inhalation, and (iii) a terminating phase. Flow transition commenced in the supraglottic region within 20ms, resulting in large- amplitude fluctuations persisting throughout the inhalation; in the nose, fluctuations that arose nearer peak flow were of much reduced intensity and diminished in the flow decay phase. Measures of gas concentration showed non-uniform build-up and wash-out of the inhaled gas in the nose. At the carina, the form of the temporal concentration profile reflected both shear dispersion and airway filling defects owing to recirculation regions.Comment: 15 page

Voxel-based modeling of airflow in the human nasal cavity

This paper describes the simulation of airflow in human nasal airways using voxel-based modeling characterized by robust, automatic, and objective grid generation. Computed tomography scans of a healthy adult nose are used to reconstruct 3D virtual models of the nasal airways. Voxel-based simulations of restful inspiratory flow are then performed using various mesh sizes to determine the level of granularity required to adequately resolve the airflow. For meshes with close voxel spacings, the model successfully reconstructs the nasal structure and predicts the overall pressure drop through the nasal cavity

Object matching using boundary descriptors

The problem of object recognition is of immense practical importance and potential, and the last decade has witnessed a number of breakthroughs in the state of the art. Most of the past object recognition work focuses on textured objects and local appearance descriptors extracted around salient points in an image. These methods fail in the matching of smooth, untextured objects for which salient point detection does not produce robust results. The recently proposed bag of boundaries (BoB) method is the first to directly address this problem. Since the texture of smooth objects is largely uninformative, BoB focuses on describing and matching objects based on their post-segmentation boundaries. Herein we address three major weaknesses of this work. The first of these is the uniform treatment of all boundary segments. Instead, we describe a method for detecting the locations and scales of salient boundary segments. Secondly, while the BoB method uses an image based elementary descriptor (HoGs + occupancy matrix), we propose a more compact descriptor based on the local profile of boundary normals’ directions. Lastly, we conduct a far more systematic evaluation, both of the bag of boundaries method and the method proposed here. Using a large public database, we demonstrate that our method exhibits greater robustness while at the same time achieving a major computational saving – object representation is extracted from an image in only 6% of the time needed to extract a bag of boundaries, and the storage requirement is similarly reduced to less than 8%

Clinical correlates of mathematical modeling of cortical spreading depression: Single‐cases study

Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis that CSD is underlying migraine aura. The highly individual and complex characteristics of the brain cor‐ tex suggest that the geometry might impact the propagation of cortical spreading depression. Methods: In a single‐case study, we simulated the CSD propagation for five migraine with aura patients, matching their symptoms during a migraine attack to the CSD wavefront propagation. This CSD wavefront was simulated on a patient‐specific tri‐ angulated cortical mesh obtained from individual MRI imaging and personalized dif‐ fusivity tensors derived locally from diffusion tensor imaging data. Results: The CSD wave propagation was simulated on both hemispheres, despite in all but one patient the symptoms were attributable to one hemisphere. The CSD wave diffused with a large wavefront toward somatosensory and prefrontal regions, devoted to pain processing. Discussion: This case‐control study suggests that the cortical geometry may con‐ tribute to the modality of CSD evolution and partly to clinical expression of aura symptoms. The simulated CSD is a large and diffuse phenomenon, possibly capa‐ ble to activate trigeminal nociceptors and to involve cortical areas devoted to pain processing