Data-driven detection of multi-messenger transients

The primary challenge in the study of explosive astrophysical transients is their detection and characterisation using multiple messengers. For this purpose, we have developed a new data-driven discovery framework, based on deep learning. We demonstrate its use for searches involving neutrinos, optical supernovae, and gamma rays. We show that we can match or substantially improve upon the performance of state-of-the-art techniques, while significantly minimising the dependence on modelling and on instrument characterisation. Particularly, our approach is intended for near- and real-time analyses, which are essential for effective follow-up of detections. Our algorithm is designed to combine a range of instruments and types of input data, representing different messengers, physical regimes, and temporal scales. The methodology is optimised for agnostic searches of unexpected phenomena, and has the potential to substantially enhance their discovery prospects.Comment: 16 page

Joint Video and Text Parsing for Understanding Events and Answering Queries

We propose a framework for parsing video and text jointly for understanding events and answering user queries. Our framework produces a parse graph that represents the compositional structures of spatial information (objects and scenes), temporal information (actions and events) and causal information (causalities between events and fluents) in the video and text. The knowledge representation of our framework is based on a spatial-temporal-causal And-Or graph (S/T/C-AOG), which jointly models possible hierarchical compositions of objects, scenes and events as well as their interactions and mutual contexts, and specifies the prior probabilistic distribution of the parse graphs. We present a probabilistic generative model for joint parsing that captures the relations between the input video/text, their corresponding parse graphs and the joint parse graph. Based on the probabilistic model, we propose a joint parsing system consisting of three modules: video parsing, text parsing and joint inference. Video parsing and text parsing produce two parse graphs from the input video and text respectively. The joint inference module produces a joint parse graph by performing matching, deduction and revision on the video and text parse graphs. The proposed framework has the following objectives: Firstly, we aim at deep semantic parsing of video and text that goes beyond the traditional bag-of-words approaches; Secondly, we perform parsing and reasoning across the spatial, temporal and causal dimensions based on the joint S/T/C-AOG representation; Thirdly, we show that deep joint parsing facilitates subsequent applications such as generating narrative text descriptions and answering queries in the forms of who, what, when, where and why. We empirically evaluated our system based on comparison against ground-truth as well as accuracy of query answering and obtained satisfactory results

Chasing a consistent picture for dark matter direct searches

In this paper we assess the present status of dark matter direct searches by means of Bayesian statistics. We consider three particle physics models for spin-independent dark matter interaction with nuclei: elastic, inelastic and isospin violating scattering. We shortly present the state of the art for the three models, marginalising over experimental systematics and astrophysical uncertainties. Whatever the scenario is, XENON100 appears to challenge the detection region of DAMA, CoGeNT and CRESST. The first aim of this study is to rigorously quantify the significance of the inconsistency between XENON100 data and the combined set of detection (DAMA, CoGeNT and CRESST together), performing two statistical tests based on the Bayesian evidence. We show that XENON100 and the combined set are inconsistent at least at 2 sigma level in all scenarios but inelastic scattering, for which the disagreement drops to 1 sigma level. Secondly we consider only the combined set and hunt the best particle physics model that accounts for the events, using Bayesian model comparison. The outcome between elastic and isospin violating scattering is inconclusive, with the odds 2:1, while inelastic scattering is disfavoured with the odds of 1:32 because of CoGeNT data. Our results are robust under reasonable prior assumptions. We conclude that the simple elastic scattering remains the best model to explain the detection regions, since the data do not support extra free parameters. Present direct searches therefore are not able to constrain the particle physics interaction of the dark matter. The outcome of consistency tests implies that either a better understanding of astrophysical and experimental uncertainties is needed, either the dark matter theoretical model is at odds with the data.Comment: 18 pages, 8 figures and 7 tables; minor revisions following referee report. Accepted for publication in Phys.Rev.

Learning mutational graphs of individual tumour evolution from single-cell and multi-region sequencing data

Background. A large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region sequencing experiments or the sequencing of individual cancer cells. However, rarely the same method can support both data types. Results. We introduce TRaIT, a computational framework to infer mutational graphs that model the accumulation of multiple types of somatic alterations driving tumour evolution. Compared to other tools, TRaIT supports multi-region and single-cell sequencing data within the same statistical framework, and delivers expressive models that capture many complex evolutionary phenomena. TRaIT improves accuracy, robustness to data-specific errors and computational complexity compared to competing methods. Conclusions. We show that the application of TRaIT to single-cell and multi-region cancer datasets can produce accurate and reliable models of single-tumour evolution, quantify the extent of intra-tumour heterogeneity and generate new testable experimental hypotheses

Knowledge-infused and Consistent Complex Event Processing over Real-time and Persistent Streams

Emerging applications in Internet of Things (IoT) and Cyber-Physical Systems (CPS) present novel challenges to Big Data platforms for performing online analytics. Ubiquitous sensors from IoT deployments are able to generate data streams at high velocity, that include information from a variety of domains, and accumulate to large volumes on disk. Complex Event Processing (CEP) is recognized as an important real-time computing paradigm for analyzing continuous data streams. However, existing work on CEP is largely limited to relational query processing, exposing two distinctive gaps for query specification and execution: (1) infusing the relational query model with higher level knowledge semantics, and (2) seamless query evaluation across temporal spaces that span past, present and future events. These allow accessible analytics over data streams having properties from different disciplines, and help span the velocity (real-time) and volume (persistent) dimensions. In this article, we introduce a Knowledge-infused CEP (X-CEP) framework that provides domain-aware knowledge query constructs along with temporal operators that allow end-to-end queries to span across real-time and persistent streams. We translate this query model to efficient query execution over online and offline data streams, proposing several optimizations to mitigate the overheads introduced by evaluating semantic predicates and in accessing high-volume historic data streams. The proposed X-CEP query model and execution approaches are implemented in our prototype semantic CEP engine, SCEPter. We validate our query model using domain-aware CEP queries from a real-world Smart Power Grid application, and experimentally analyze the benefits of our optimizations for executing these queries, using event streams from a campus-microgrid IoT deployment.Comment: 34 pages, 16 figures, accepted in Future Generation Computer Systems, October 27, 201