Washington University Magazine, October 2010

https://digitalcommons.wustl.edu/ad_wumag/1193/thumbnail.jp

October 3, 2008, Ohio University Board of Trustees Meeting Minutes

Meeting minutes document the activities of Ohio University\u27s Board of Trustees

Report on the 2015 NSF Workshop on Unified Annotation Tooling

On March 30 & 31, 2015, an international group of twenty-three researchers with expertise in linguistic annotation convened in Sunny Isles Beach, Florida to discuss problems with and potential solutions for the state of linguistic annotation tooling. The participants comprised 14 researchers from the U.S. and 9 from outside the U.S., with 7 countries and 4 continents represented, and hailed from fields and specialties including computational linguistics, artificial intelligence, speech processing, multi-modal data processing, clinical & medical natural language processing, linguistics, documentary linguistics, sign-language linguistics, corpus linguistics, and the digital humanities. The motivating problem of the workshop was the balkanization of annotation tooling, namely, that even though linguistic annotation requires sophisticated tool support to efficiently generate high-quality data, the landscape of tools for the field is fractured, incompatible, inconsistent, and lacks key capabilities. The overall goal of the workshop was to chart the way forward, centering on five key questions: (1) What are the problems with current tool landscape? (2) What are the possible benefits of solving some or all of these problems? (3) What capabilities are most needed? (4) How should we go about implementing these capabilities? And, (5) How should we ensure longevity and sustainability of the solution? I surveyed the participants before their arrival, which provided significant raw material for ideas, and the workshop discussion itself resulted in identification of ten specific classes of problems, five sets of most-needed capabilities. Importantly, we identified annotation project managers in computational linguistics as the key recipients and users of any solution, thereby succinctly addressing questions about the scope and audience of potential solutions. We discussed management and sustainability of potential solutions at length. The participants agreed on sixteen recommendations for future work. This technical report contains a detailed discussion of all these topics, a point-by-point review of the discussion in the workshop as it unfolded, detailed information on the participants and their expertise, and the summarized data from the surveys

VCU voice (1989-10-13)

VCU Today, the University’s first official administrative organ, began as a somewhat irregular monthly publication but moved to a bi-weekly newspaper format in the 1980s. The newspaper changed its name to VCU Voice in 1988 and ten years later it appeared under the title UniverCity News. As it neared the end of its run as a physical newspaper, the publication became simply VCU News. These four publications were essentially the same periodical published under different titles by the Office of University Relations. VCU News appeared online for the first time in 2002.https://scholarscompass.vcu.edu/vcv/1021/thumbnail.jp

Doctor of Philosophy

dissertationRapidly evolving technologies such as chip arrays and next-generation sequencing are uncovering human genetic variants at an unprecedented pace. Unfortunately, this ever growing collection of gene sequence variation has limited clinical utility without clear association to disease outcomes. As electronic medical records begin to incorporate genetic information, gene variant classification and accurate interpretation of gene test results plays a critical role in customizing patient therapy. To verify the functional impact of a given gene variant, laboratories rely on confirming evidence such as previous literature reports, patient history and disease segregation in a family. By definition variants of uncertain significance (VUS) lack this supporting evidence and in such cases, computational tools are often used to evaluate the predicted functional impact of a gene mutation. This study evaluates leveraging high quality genotype-phenotype disease variant data from 20 genes and 3986 variants, to develop gene-specific predictors utilizing a combination of changes in primary amino acid sequence, amino acid properties as descriptors of mutation severity and Naïve Bayes classification. A Primary Sequence Amino Acid Properties (PSAAP) prediction algorithm was then combined with well established predictors in a weighted Consensus sum in context of gene-specific reference intervals for known phenotypes. PSAAP and Consensus were also used to evaluate known variants of uncertain significance in the RET proto-oncogene as a model gene. The PSAAP algorithm was successfully extended to many genes and diseases. Gene-specific algorithms typically outperform generalized prediction tools. Characteristic mutation properties of a given gene and disease may be lost when diluted into genomewide data sets. A reliable computational phenotype classification framework with quantitative metrics and disease specific reference ranges allows objective evaluation of novel or uncertain gene variants and augments decision making when confirming clinical information is limited

Complex adaptive systems based data integration : theory and applications

Data Definition Languages (DDLs) have been created and used to represent data in programming languages and in database dictionaries. This representation includes descriptions in the form of data fields and relations in the form of a hierarchy, with the common exception of relational databases where relations are flat. Network computing created an environment that enables relatively easy and inexpensive exchange of data. What followed was the creation of new DDLs claiming better support for automatic data integration. It is uncertain from the literature if any real progress has been made toward achieving an ideal state or limit condition of automatic data integration. This research asserts that difficulties in accomplishing integration are indicative of socio-cultural systems in general and are caused by some measurable attributes common in DDLs. This research’s main contributions are: (1) a theory of data integration requirements to fully support automatic data integration from autonomous heterogeneous data sources; (2) the identification of measurable related abstract attributes (Variety, Tension, and Entropy); (3) the development of tools to measure them. The research uses a multi-theoretic lens to define and articulate these attributes and their measurements. The proposed theory is founded on the Law of Requisite Variety, Information Theory, Complex Adaptive Systems (CAS) theory, Sowa’s Meaning Preservation framework and Zipf distributions of words and meanings. Using the theory, the attributes, and their measures, this research proposes a framework for objectively evaluating the suitability of any data definition language with respect to degrees of automatic data integration. This research uses thirteen data structures constructed with various DDLs from the 1960\u27s to date. No DDL examined (and therefore no DDL similar to those examined) is designed to satisfy the law of requisite variety. No DDL examined is designed to support CAS evolutionary processes that could result in fully automated integration of heterogeneous data sources. There is no significant difference in measures of Variety, Tension, and Entropy among DDLs investigated in this research. A direction to overcome the common limitations discovered in this research is suggested and tested by proposing GlossoMote, a theoretical mathematically sound description language that satisfies the data integration theory requirements. The DDL, named GlossoMote, is not merely a new syntax, it is a drastic departure from existing DDL constructs. The feasibility of the approach is demonstrated with a small scale experiment and evaluated using the proposed assessment framework and other means. The promising results require additional research to evaluate GlossoMote’s approach commercial use potential

Expectations and expertise in artificial intelligence: specialist views and historical perspectives on conceptualisation, promise, and funding

Artificial intelligence’s (AI) distinctiveness as a technoscientific field that imitates the ability to think went through a resurgence of interest post-2010, attracting a flood of scientific and popular expectations as to its utopian or dystopian transformative consequences. This thesis offers observations about the formation and dynamics of expectations based on documentary material from the previous periods of perceived AI hype (1960-1975 and 1980-1990, including in-between periods of perceived dormancy), and 25 interviews with UK-based AI specialists, directly involved with its development, who commented on the issues during the crucial period of uncertainty (2017-2019) and intense negotiation through which AI gained momentum prior to its regulation and relatively stabilised new rounds of long-term investment (2020-2021). This examination applies and contributes to longitudinal studies in the sociology of expectations (SoE) and studies of experience and expertise (SEE) frameworks, proposing a historical sociology of expertise and expectations framework. The research questions, focusing on the interplay between hype mobilisation and governance, are: (1) What is the relationship between AI practical development and the broader expectational environment, in terms of funding and conceptualisation of AI? (2) To what extent does informal and non-developer assessment of expectations influence formal articulations of foresight? (3) What can historical examinations of AI’s conceptual and promissory settings tell about the current rebranding of AI? The following contributions are made: (1) I extend SEE by paying greater attention to the interplay between technoscientific experts and wider collective arenas of discourse amongst non-specialists and showing how AI’s contemporary research cultures are overwhelmingly influenced by the hype environment but also contribute to it. This further highlights the interaction between competing rationales focusing on exploratory, curiosity-driven scientific research against exploitation-oriented strategies at formal and informal levels. (2) I suggest benefits of examining promissory environments in AI and related technoscientific fields longitudinally, treating contemporary expectations as historical products of sociotechnical trajectories through an authoritative historical reading of AI’s shifting conceptualisation and attached expectations as a response to availability of funding and broader national imaginaries. This comes with the benefit of better perceiving technological hype as migrating from social group to social group instead of fading through reductionist cycles of disillusionment; either by rebranding of technical operations, or by the investigation of a given field by non-technical practitioners. It also sensitises to critically examine broader social expectations as factors for shifts in perception about theoretical/basic science research transforming into applied technological fields. Finally, (3) I offer a model for understanding the significance of interplay between conceptualisations, promising, and motivations across groups within competing dynamics of collective and individual expectations and diverse sources of expertise