Architecture and Design of Medical Processor Units for Medical Networks

This paper introduces analogical and deductive methodologies for the design medical processor units (MPUs). From the study of evolution of numerous earlier processors, we derive the basis for the architecture of MPUs. These specialized processors perform unique medical functions encoded as medical operational codes (mopcs). From a pragmatic perspective, MPUs function very close to CPUs. Both processors have unique operation codes that command the hardware to perform a distinct chain of subprocesses upon operands and generate a specific result unique to the opcode and the operand(s). In medical environments, MPU decodes the mopcs and executes a series of medical sub-processes and sends out secondary commands to the medical machine. Whereas operands in a typical computer system are numerical and logical entities, the operands in medical machine are objects such as such as patients, blood samples, tissues, operating rooms, medical staff, medical bills, patient payments, etc. We follow the functional overlap between the two processes and evolve the design of medical computer systems and networks.Comment: 17 page

Machine Learning with Abstention for Automated Liver Disease Diagnosis

This paper presents a novel approach for detection of liver abnormalities in an automated manner using ultrasound images. For this purpose, we have implemented a machine learning model that can not only generate labels (normal and abnormal) for a given ultrasound image but it can also detect when its prediction is likely to be incorrect. The proposed model abstains from generating the label of a test example if it is not confident about its prediction. Such behavior is commonly practiced by medical doctors who, when given insufficient information or a difficult case, can chose to carry out further clinical or diagnostic tests before generating a diagnosis. However, existing machine learning models are designed in a way to always generate a label for a given example even when the confidence of their prediction is low. We have proposed a novel stochastic gradient based solver for the learning with abstention paradigm and use it to make a practical, state of the art method for liver disease classification. The proposed method has been benchmarked on a data set of approximately 100 patients from MINAR, Multan, Pakistan and our results show that the proposed scheme offers state of the art classification performance.Comment: Preprint version before submission for publication. complete version published in proc. 15th International Conference on Frontiers of Information Technology (FIT 2017), December 18-20, 2017, Islamabad, Pakistan. http://ieeexplore.ieee.org/document/8261064

Association Rules Mining Based Clinical Observations

Healthcare institutes enrich the repository of patients' disease related information in an increasing manner which could have been more useful by carrying out relational analysis. Data mining algorithms are proven to be quite useful in exploring useful correlations from larger data repositories. In this paper we have implemented Association Rules mining based a novel idea for finding co-occurrences of diseases carried by a patient using the healthcare repository. We have developed a system-prototype for Clinical State Correlation Prediction (CSCP) which extracts data from patients' healthcare database, transforms the OLTP data into a Data Warehouse by generating association rules. The CSCP system helps reveal relations among the diseases. The CSCP system predicts the correlation(s) among primary disease (the disease for which the patient visits the doctor) and secondary disease/s (which is/are other associated disease/s carried by the same patient having the primary disease).Comment: 5 pages, MEDINFO 2010, C. Safran et al. (Eds.), IOS Pres

Validation of machine learning models to detect amyloid pathologies across institutions.

Semi-quantitative scoring schemes like the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) are the most commonly used method in Alzheimer's disease (AD) neuropathology practice. Computational approaches based on machine learning have recently generated quantitative scores for whole slide images (WSIs) that are highly correlated with human derived semi-quantitative scores, such as those of CERAD, for Alzheimer's disease pathology. However, the robustness of such models have yet to be tested in different cohorts. To validate previously published machine learning algorithms using convolutional neural networks (CNNs) and determine if pathological heterogeneity may alter algorithm derived measures, 40 cases from the Goizueta Emory Alzheimer's Disease Center brain bank displaying an array of pathological diagnoses (including AD with and without Lewy body disease (LBD), and / or TDP-43-positive inclusions) and levels of Aβ pathologies were evaluated. Furthermore, to provide deeper phenotyping, amyloid burden in gray matter vs whole tissue were compared, and quantitative CNN scores for both correlated significantly to CERAD-like scores. Quantitative scores also show clear stratification based on AD pathologies with or without additional diagnoses (including LBD and TDP-43 inclusions) vs cases with no significant neurodegeneration (control cases) as well as NIA Reagan scoring criteria. Specifically, the concomitant diagnosis group of AD + TDP-43 showed significantly greater CNN-score for cored plaques than the AD group. Finally, we report that whole tissue computational scores correlate better with CERAD-like categories than focusing on computational scores from a field of view with densest pathology, which is the standard of practice in neuropathological assessment per CERAD guidelines. Together these findings validate and expand CNN models to be robust to cohort variations and provide additional proof-of-concept for future studies to incorporate machine learning algorithms into neuropathological practice