A bi-objective genetic algorithm approach to risk mitigation in project scheduling

A problem of risk mitigation in project scheduling is formulated as a bi-objective optimization problem, where the expected makespan and the expected total cost are both to be minimized. The expected total cost is the sum of four cost components: overhead cost, activity execution cost, cost of reducing risks and penalty cost for tardiness. Risks for activities are predefined. For each risk at an activity, various levels are defined, which correspond to the results of different preventive measures. Only those risks with a probable impact on the duration of the related activity are considered here. Impacts of risks are not only accounted for through the expected makespan but are also translated into cost and thus have an impact on the expected total cost. An MIP model and a heuristic solution approach based on genetic algorithms (GAs) is proposed. The experiments conducted indicate that GAs provide a fast and effective solution approach to the problem. For smaller problems, the results obtained by the GA are very good. For larger problems, there is room for improvement

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

An integrated approach for requirement selection and scheduling in software release planning

It is essential for product software companies to decide which requirements should be included in the next release and to make an appropriate time plan of the development project. Compared to the extensive research done on requirement selection, very little research has been performed on time scheduling. In this paper, we introduce two integer linear programming models that integrate time scheduling into software release planning. Given the resource and precedence constraints, our first model provides a schedule for developing the requirements such that the project duration is minimized. Our second model combines requirement selection and scheduling, so that it not only maximizes revenues but also simultaneously calculates an on-time-delivery project schedule. Since requirement dependencies are essential for scheduling the development process, we present a more detailed analysis of these dependencies. Furthermore, we present two mechanisms that facilitate dynamic adaptation for over-estimation or under-estimation of revenues or processing time, one of which includes the Scrum methodology. Finally, several simulations based on real-life data are performed. The results of these simulations indicate that requirement dependency can significantly influence the requirement selection and the corresponding project plan. Moreover, the model for combined requirement selection and scheduling outperforms the sequential selection and scheduling approach in terms of efficiency and on-time delivery. \u

Train-scheduling optimization model for railway networks with multiplatform stations

This paper focuses on optimizing the schedule of trains on railway networks composed of busy complex stations. A mathematical formulation of this problem is provided as a Mixed Integer Linear Program (MILP). However, the creation of an optimal new timetable is an NP-hard problem; therefore, the MILP can be solved for easy cases, computation time being impractical for more complex examples. In these cases, a heuristic approach is provided that makes use of genetic algorithms to find a good solution jointly with heuristic techniques to generate an initial population. The algorithm was applied to a number of problem instances producing feasible, though not optimal, solutions in several seconds on a laptop, and compared to other proposals. Some improvements are suggested to obtain better results and further improve computation time. Rail transport is recognized as a sustainable and energy-efficient means of transport. Moreover, each freight train can take a large number of trucks off the roads, making them safer. Studies in this field can help to make railways more attractive to travelers by reducing operative cost, and increasing the number of services and their punctuality. To improve the transit system and service, it is necessary to build optimal train scheduling. There is an interest from the industry in automating the scheduling process. Fast computerized train scheduling, moreover, can be used to explore the effects of alternative draft timetables, operating policies, station layouts, and random delays or failures.Postprint (published version

An efficient memetic, permutation-based evolutionary algorithm for real-world train timetabling

Train timetabling is a difficult and very tightly constrained combinatorial problem that deals with the construction of train schedules. We focus on the particular problem of local reconstruction of the schedule following a small perturbation, seeking minimisation of the total accumulated delay by adapting times of departure and arrival for each train and allocation of resources (tracks, routing nodes, etc.). We describe a permutation-based evolutionary algorithm that relies on a semi-greedy heuristic to gradually reconstruct the schedule by inserting trains one after the other following the permutation. This algorithm can be hybridised with ILOG commercial MIP programming tool CPLEX in a coarse-grained manner: the evolutionary part is used to quickly obtain a good but suboptimal solution and this intermediate solution is refined using CPLEX. Experimental results are presented on a large real-world case involving more than one million variables and 2 million constraints. Results are surprisingly good as the evolutionary algorithm, alone or hybridised, produces excellent solutions much faster than CPLEX alone