Methods for protein complex prediction and their contributions towards understanding the organization, function and dynamics of complexes

Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand the functional organization of cells. In this review, we discuss the key contributions of computational methods developed till date (approximately between 2003 and 2015) for identifying complexes from the network of interacting proteins (PPI network). We evaluate in depth the performance of these methods on PPI datasets from yeast, and highlight challenges faced by these methods, in particular detection of sparse and small or sub- complexes and discerning of overlapping complexes. We describe methods for integrating diverse information including expression profiles and 3D structures of proteins with PPI networks to understand the dynamics of complex formation, for instance, of time-based assembly of complex subunits and formation of fuzzy complexes from intrinsically disordered proteins. Finally, we discuss methods for identifying dysfunctional complexes in human diseases, an application that is proving invaluable to understand disease mechanisms and to discover novel therapeutic targets. We hope this review aptly commemorates a decade of research on computational prediction of complexes and constitutes a valuable reference for further advancements in this exciting area.Comment: 1 Tabl

On the Topology Maintenance of Dynamic P2P Overlays through Self-Healing Local Interactions

This paper deals with the use of self-organizing protocols to improve the reliability of dynamic Peer-to-Peer (P2P) overlay networks. We present two approaches, that employ local knowledge of the 2nd neighborhood of nodes. The first scheme is a simple protocol requiring interactions among nodes and their direct neighbors. The second scheme extends this approach by resorting to the Edge Clustering Coefficient (ECC), a local measure that allows to identify those edges that connect different clusters in an overlay. A simulation assessment is presented, which evaluates these protocols over uniform networks, clustered networks and scale-free networks. Different failure modes are considered. Results demonstrate the viability of the proposal.Comment: A revised version of the paper appears in Proc. of the IFIP Networking 2014 Conference, IEEE, Trondheim, (Norway), June 201

Multimedia delivery in the future internet

The term “Networked Media” implies that all kinds of media including text, image, 3D graphics, audio and video are produced, distributed, shared, managed and consumed on-line through various networks, like the Internet, Fiber, WiFi, WiMAX, GPRS, 3G and so on, in a convergent manner [1]. This white paper is the contribution of the Media Delivery Platform (MDP) cluster and aims to cover the Networked challenges of the Networked Media in the transition to the Future of the Internet. Internet has evolved and changed the way we work and live. End users of the Internet have been confronted with a bewildering range of media, services and applications and of technological innovations concerning media formats, wireless networks, terminal types and capabilities. And there is little evidence that the pace of this innovation is slowing. Today, over one billion of users access the Internet on regular basis, more than 100 million users have downloaded at least one (multi)media file and over 47 millions of them do so regularly, searching in more than 160 Exabytes1 of content. In the near future these numbers are expected to exponentially rise. It is expected that the Internet content will be increased by at least a factor of 6, rising to more than 990 Exabytes before 2012, fuelled mainly by the users themselves. Moreover, it is envisaged that in a near- to mid-term future, the Internet will provide the means to share and distribute (new) multimedia content and services with superior quality and striking flexibility, in a trusted and personalized way, improving citizens’ quality of life, working conditions, edutainment and safety. In this evolving environment, new transport protocols, new multimedia encoding schemes, cross-layer inthe network adaptation, machine-to-machine communication (including RFIDs), rich 3D content as well as community networks and the use of peer-to-peer (P2P) overlays are expected to generate new models of interaction and cooperation, and be able to support enhanced perceived quality-of-experience (PQoE) and innovative applications “on the move”, like virtual collaboration environments, personalised services/ media, virtual sport groups, on-line gaming, edutainment. In this context, the interaction with content combined with interactive/multimedia search capabilities across distributed repositories, opportunistic P2P networks and the dynamic adaptation to the characteristics of diverse mobile terminals are expected to contribute towards such a vision. Based on work that has taken place in a number of EC co-funded projects, in Framework Program 6 (FP6) and Framework Program 7 (FP7), a group of experts and technology visionaries have voluntarily contributed in this white paper aiming to describe the status, the state-of-the art, the challenges and the way ahead in the area of Content Aware media delivery platforms

Modeling and Recognition of Smart Grid Faults by a Combined Approach of Dissimilarity Learning and One-Class Classification

Detecting faults in electrical power grids is of paramount importance, either from the electricity operator and consumer viewpoints. Modern electric power grids (smart grids) are equipped with smart sensors that allow to gather real-time information regarding the physical status of all the component elements belonging to the whole infrastructure (e.g., cables and related insulation, transformers, breakers and so on). In real-world smart grid systems, usually, additional information that are related to the operational status of the grid itself are collected such as meteorological information. Designing a suitable recognition (discrimination) model of faults in a real-world smart grid system is hence a challenging task. This follows from the heterogeneity of the information that actually determine a typical fault condition. The second point is that, for synthesizing a recognition model, in practice only the conditions of observed faults are usually meaningful. Therefore, a suitable recognition model should be synthesized by making use of the observed fault conditions only. In this paper, we deal with the problem of modeling and recognizing faults in a real-world smart grid system, which supplies the entire city of Rome, Italy. Recognition of faults is addressed by following a combined approach of multiple dissimilarity measures customization and one-class classification techniques. We provide here an in-depth study related to the available data and to the models synthesized by the proposed one-class classifier. We offer also a comprehensive analysis of the fault recognition results by exploiting a fuzzy set based reliability decision rule