脳情報学に基づく人間の認知・感情とその相互関係における研究

This dissertation concentrates on the neural substrates underlying the human cognition, emotion, and their interactions. Directed by the systematic methodology of brain informatics (BI), functional magnetic resonance imaging (fMRI) experiments were performed to investigate the information processing of mental arithmetic, self-regulation of aversive emotion, and attention deployment of patients with major depressive disorder (MDD), which were utilized as typical paradigms to study the relationship between cognition and emotion. Four major findings could be concluded: 1) mental addition calculation is naturally automaticwhile subtraction calculation is complex; 2) both bottom-up suppression and top-down regulation are engaged in the self-recovery from aversive emotion; 3) cognition and emotion influence each other, since some cognitive resources and brain regions are shared by the both brain functions; 4) Abnormal functioning in the joint brain areas is more likely to lead to impairments in both cognitive and emotional functions simultaneously. Our findings demonstrate that human cognition and emotion are not isolated, but compete for cognitive resources for attention and executive control. The present thesis can also be considered as a case study for demonstrating the advances of BI methodology in accelerating progress towards a multi-level understanding of brain structure and function.学位記番号:工博甲1

脳情報学に基づく人間の認知・感情とその相互関係における研究

This dissertation concentrates on the neural substrates underlying the human cognition, emotion, and their interactions. Directed by the systematic methodology of brain informatics (BI), functional magnetic resonance imaging (fMRI) experiments were performed to investigate the information processing of mental arithmetic, self-regulation of aversive emotion, and attention deployment of patients with major depressive disorder (MDD), which were utilized as typical paradigms to study the relationship between cognition and emotion. Four major findings could be concluded: 1) mental addition calculation is naturally automaticwhile subtraction calculation is complex; 2) both bottom-up suppression and top-down regulation are engaged in the self-recovery from aversive emotion; 3) cognition and emotion influence each other, since some cognitive resources and brain regions are shared by the both brain functions; 4) Abnormal functioning in the joint brain areas is more likely to lead to impairments in both cognitive and emotional functions simultaneously. Our findings demonstrate that human cognition and emotion are not isolated, but compete for cognitive resources for attention and executive control. The present thesis can also be considered as a case study for demonstrating the advances of BI methodology in accelerating progress towards a multi-level understanding of brain structure and function.学位記番号:工博甲1