Digital Image Analysis of Vitiligo for Monitoring of Vitiligo Treatment

Vitiligo is an acquired pigmentary skin disorder characterized by depigmented macules that result from damage to and destruction of epidermal melanocytes. Visually, the vitiligous areas are paler in contrast to normal skin or completely white due to the lack of pigment melanin. The course of vitiligo is unpredictable where the vitiligous skin lesions may remain stable for years before worsening. Vitiligo treatments have two objectives, to arrest disease progression and to re-pigment the vitiligous skin lesions. To monitor the efficacy of the treatment, dermatologists observe the disease directly, or indirectly using digital photos. Currently there is no objective method to determine the efficacy of the vitiligo treatment. Physician's Global Assessment (PGA) scale is the current scoring system used by dermatologists to evaluate the treatment. The scale is based on the degree of repigmentation within lesions over time. This quantitative tool however may not be help to detect slight changes due to treatment as it would still be largely dependent on the human eye and judgment to produce the scorings. In addition, PGA score is also subjective, as it varies with dermatologists. The progression of vitiligo treatment can be very slow and can take more than 6 months. It is observed that dermatologists find it visually hard to determine the areas of skin repigmentation due to this slow progress and as a result the observations are made after a longer time frame. The objective of this research is to develop a tool that enables dermatologists to determine and quantify areas of repigmentation objectively over a shorter time frame during treatment. The approaches towards achieving this objective are based on digital image processing techniques. Skin color is due to the combination of skin histological parameters, namely pigment melanin and haemoglobin. However in digital imaging, color is produced by combining three different spectral bands, namely red, green, and blue (RGB). It is believed that the spatial distribution of melanin and haemoglobin in skin image could be separated. It is found that skin color distribution lies on a two-dimensional melanin-haemoglobin color subspace. In order to determine repigmentation (due to pigment melanin) it is necessary to perform a conversion from RGB skin image to this two-dimensional color subspace. Using principal component analysis (PCA) as a dimensional reduction tool, the two-dimensional subspace can be represented by its first and second principal components. Independent component analysis is employed to convert the twodimensional subspace into a skin image that represents skin areas due to melanin and haemoglobin only. In the skin image that represents skin areas due to melanin, vitiligous skin lesions are identified as skin areas that lack melanin. Segmentation is performed to separate the healthy skin and the vitiligous lesions. The difference in the vitiligous surface areas between skin images before and after treatment will be expressed as a percentage of repigmentation in each vitiligo lesion. This percentage will represent the repigmentation progression of a particular body region. Results of preliminary and pre-clinical trial study show that our vitiligo monitoring system has been able to determine repigmentation progression objectively and thus treatment efficacy on a shorter time cycle. An intensive clinical trial is currently undertaken in Hospital Kuala Lumpur using our developed system. VI

Coarse to Fine Face Detection Based on Skin Color Adaption

Abstract. In this paper we present a skin color approach for fast and accurate face detection which combines skin color learning and image segmentation. This approach starts from a coarse segmentation which provides regions of homogeneous statistical color distribution. Some regions represent parts of human skin and are selected by minimizing an error between the color distribution of each region and the output of a compression decompression neural network, which learns skin color distribution for several populations of different ethnicity. This ANN is used to find a collection of skin regions which are used to estimate the new parameters of the Gaussian models using a 2-means fuzzy clustering in order to adapt these parameters to the context of the input image. A Bayesian frameworkis used to perform a finer classification and makes the skin and face detection process invariant to scale and lighting conditions. Finally, a face shape based model is used to validate or not the face hypothesis on each skin region.

A Software Framework for PCA-based Face Recognition

Face recognition, as one of the major biometrics identification methods, has been applied in different fields involving economics, military, e-commerce, and security. Its touchless identification process and non-compulsory rule to users are irreplacable by other approaches, such as iris recognition or fingerprint recognition. Among all face recognition techniques, principal component anaylsis (PCA) was proposed in the earliest stage; however, it is still attracting researchers in this field because of its property of reducing data dimensionality without losing important information. PCA-based face recognition has been studied for decades. There exist some image processing toolkits like OpenCV, which have implemented the PCA algorithm and associated methods. Nevertheless, establishing a PCA-based face recognition system is still time-consuming, since there are different problems that need to be considered in practical applications, such as illumination, facial expression, or shooting angle, which can hardly be solved by the toolkits. Furthermore, it still costs a lot of effort for software developers to integrate the implementations of the toolkits with their own applications. Therefore, the thesis provides a software framework for PCA-based face recognition aimed at assisting software developers to customize their applications efficiently. The framework describes the complete process of PCA-based face recognition, and in each step, multiple variations are offered for different requirements. Through various combination of these variations, at least 108 variations can be produced by the framework. Moreover, some of the variations in the same step can work collaboratively and some steps can be omitted in specific situations; thus, the total number of variations exceeds 150. The implementation of all approaches presented in the framework is provided

A Methodology for Extracting Human Bodies from Still Images

Monitoring and surveillance of humans is one of the most prominent applications of today and it is expected to be part of many future aspects of our life, for safety reasons, assisted living and many others. Many efforts have been made towards automatic and robust solutions, but the general problem is very challenging and remains still open. In this PhD dissertation we examine the problem from many perspectives. First, we study the performance of a hardware architecture designed for large-scale surveillance systems. Then, we focus on the general problem of human activity recognition, present an extensive survey of methodologies that deal with this subject and propose a maturity metric to evaluate them. One of the numerous and most popular algorithms for image processing found in the field is image segmentation and we propose a blind metric to evaluate their results regarding the activity at local regions. Finally, we propose a fully automatic system for segmenting and extracting human bodies from challenging single images, which is the main contribution of the dissertation. Our methodology is a novel bottom-up approach relying mostly on anthropometric constraints and is facilitated by our research in the fields of face, skin and hands detection. Experimental results and comparison with state-of-the-art methodologies demonstrate the success of our approach