From Common to Special: When Multi-Attribute Learning Meets Personalized Opinions

Visual attributes, which refer to human-labeled semantic annotations, have gained increasing popularity in a wide range of real world applications. Generally, the existing attribute learning methods fall into two categories: one focuses on learning user-specific labels separately for different attributes, while the other one focuses on learning crowd-sourced global labels jointly for multiple attributes. However, both categories ignore the joint effect of the two mentioned factors: the personal diversity with respect to the global consensus; and the intrinsic correlation among multiple attributes. To overcome this challenge, we propose a novel model to learn user-specific predictors across multiple attributes. In our proposed model, the diversity of personalized opinions and the intrinsic relationship among multiple attributes are unified in a common-to-special manner. To this end, we adopt a three-component decomposition. Specifically, our model integrates a common cognition factor, an attribute-specific bias factor and a user-specific bias factor. Meanwhile Lasso and group Lasso penalties are adopted to leverage efficient feature selection. Furthermore, theoretical analysis is conducted to show that our proposed method could reach reasonable performance. Eventually, the empirical study carried out in this paper demonstrates the effectiveness of our proposed method

Conic Multi-Task Classification

Traditionally, Multi-task Learning (MTL) models optimize the average of task-related objective functions, which is an intuitive approach and which we will be referring to as Average MTL. However, a more general framework, referred to as Conic MTL, can be formulated by considering conic combinations of the objective functions instead; in this framework, Average MTL arises as a special case, when all combination coefficients equal 1. Although the advantage of Conic MTL over Average MTL has been shown experimentally in previous works, no theoretical justification has been provided to date. In this paper, we derive a generalization bound for the Conic MTL method, and demonstrate that the tightest bound is not necessarily achieved, when all combination coefficients equal 1; hence, Average MTL may not always be the optimal choice, and it is important to consider Conic MTL. As a byproduct of the generalization bound, it also theoretically explains the good experimental results of previous relevant works. Finally, we propose a new Conic MTL model, whose conic combination coefficients minimize the generalization bound, instead of choosing them heuristically as has been done in previous methods. The rationale and advantage of our model is demonstrated and verified via a series of experiments by comparing with several other methods.Comment: Accepted by European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECMLPKDD)-201

TopologyNet: Topology based deep convolutional neural networks for biomolecular property predictions

Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered by the entangled geometric complexity and biological complexity. We introduce topology, i.e., element specific persistent homology (ESPH), to untangle geometric complexity and biological complexity. ESPH represents 3D complex geometry by one-dimensional (1D) topological invariants and retains crucial biological information via a multichannel image representation. It is able to reveal hidden structure-function relationships in biomolecules. We further integrate ESPH and convolutional neural networks to construct a multichannel topological neural network (TopologyNet) for the predictions of protein-ligand binding affinities and protein stability changes upon mutation. To overcome the limitations to deep learning arising from small and noisy training sets, we present a multitask topological convolutional neural network (MT-TCNN). We demonstrate that the present TopologyNet architectures outperform other state-of-the-art methods in the predictions of protein-ligand binding affinities, globular protein mutation impacts, and membrane protein mutation impacts.Comment: 20 pages, 8 figures, 5 table