10,101 research outputs found
A Mutagenetic Tree Hidden Markov Model for Longitudinal Clonal HIV Sequence Data
RNA viruses provide prominent examples of measurably evolving populations. In
HIV infection, the development of drug resistance is of particular interest,
because precise predictions of the outcome of this evolutionary process are a
prerequisite for the rational design of antiretroviral treatment protocols. We
present a mutagenetic tree hidden Markov model for the analysis of longitudinal
clonal sequence data. Using HIV mutation data from clinical trials, we estimate
the order and rate of occurrence of seven amino acid changes that are
associated with resistance to the reverse transcriptase inhibitor efavirenz.Comment: 20 pages, 6 figure
Direct Estimation of Differences in Causal Graphs
We consider the problem of estimating the differences between two causal
directed acyclic graph (DAG) models with a shared topological order given
i.i.d. samples from each model. This is of interest for example in genomics,
where changes in the structure or edge weights of the underlying causal graphs
reflect alterations in the gene regulatory networks. We here provide the first
provably consistent method for directly estimating the differences in a pair of
causal DAGs without separately learning two possibly large and dense DAG models
and computing their difference. Our two-step algorithm first uses invariance
tests between regression coefficients of the two data sets to estimate the
skeleton of the difference graph and then orients some of the edges using
invariance tests between regression residual variances. We demonstrate the
properties of our method through a simulation study and apply it to the
analysis of gene expression data from ovarian cancer and during T-cell
activation
DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways
Clinical researchers use disease progression models to understand patient
status and characterize progression patterns from longitudinal health records.
One approach for disease progression modeling is to describe patient status
using a small number of states that represent distinctive distributions over a
set of observed measures. Hidden Markov models (HMMs) and its variants are a
class of models that both discover these states and make inferences of health
states for patients. Despite the advantages of using the algorithms for
discovering interesting patterns, it still remains challenging for medical
experts to interpret model outputs, understand complex modeling parameters, and
clinically make sense of the patterns. To tackle these problems, we conducted a
design study with clinical scientists, statisticians, and visualization
experts, with the goal to investigate disease progression pathways of chronic
diseases, namely type 1 diabetes (T1D), Huntington's disease, Parkinson's
disease, and chronic obstructive pulmonary disease (COPD). As a result, we
introduce DPVis which seamlessly integrates model parameters and outcomes of
HMMs into interpretable and interactive visualizations. In this study, we
demonstrate that DPVis is successful in evaluating disease progression models,
visually summarizing disease states, interactively exploring disease
progression patterns, and building, analyzing, and comparing clinically
relevant patient subgroups.Comment: to appear at IEEE Transactions on Visualization and Computer Graphic
- …