Multi-class protein fold classification using a new ensemble machine learning approach.

Protein structure classification represents an important process in understanding the associations between sequence and structure as well as possible functional and evolutionary relationships. Recent structural genomics initiatives and other high-throughput experiments have populated the biological databases at a rapid pace. The amount of structural data has made traditional methods such as manual inspection of the protein structure become impossible. Machine learning has been widely applied to bioinformatics and has gained a lot of success in this research area. This work proposes a novel ensemble machine learning method that improves the coverage of the classifiers under the multi-class imbalanced sample sets by integrating knowledge induced from different base classifiers, and we illustrate this idea in classifying multi-class SCOP protein fold data. We have compared our approach with PART and show that our method improves the sensitivity of the classifier in protein fold classification. Furthermore, we have extended this method to learning over multiple data types, preserving the independence of their corresponding data sources, and show that our new approach performs at least as well as the traditional technique over a single joined data source. These experimental results are encouraging, and can be applied to other bioinformatics problems similarly characterised by multi-class imbalanced data sets held in multiple data sources

Generic Black-Box End-to-End Attack Against State of the Art API Call Based Malware Classifiers

In this paper, we present a black-box attack against API call based machine learning malware classifiers, focusing on generating adversarial sequences combining API calls and static features (e.g., printable strings) that will be misclassified by the classifier without affecting the malware functionality. We show that this attack is effective against many classifiers due to the transferability principle between RNN variants, feed forward DNNs, and traditional machine learning classifiers such as SVM. We also implement GADGET, a software framework to convert any malware binary to a binary undetected by malware classifiers, using the proposed attack, without access to the malware source code.Comment: Accepted as a conference paper at RAID 201

Wearable Sensor Data Based Human Activity Recognition using Machine Learning: A new approach

Recent years have witnessed the rapid development of human activity recognition (HAR) based on wearable sensor data. One can find many practical applications in this area, especially in the field of health care. Many machine learning algorithms such as Decision Trees, Support Vector Machine, Naive Bayes, K-Nearest Neighbor, and Multilayer Perceptron are successfully used in HAR. Although these methods are fast and easy for implementation, they still have some limitations due to poor performance in a number of situations. In this paper, we propose a novel method based on the ensemble learning to boost the performance of these machine learning methods for HAR