6,345 research outputs found

    Classification of epilepsy using computational intelligence techniques

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    AbstractThis paper deals with a real-life application of epilepsy classification, where three phases of absence seizure, namely pre-seizure, seizure and seizure-free, are classified using real clinical data. Artificial neural network (ANN) and support vector machines (SVMs) combined with supervised learning algorithms, and k-means clustering (k-MC) combined with unsupervised techniques are employed to classify the three seizure phases. Different techniques to combine binary SVMs, namely One Vs One (OvO), One Vs All (OvA) and Binary Decision Tree (BDT), are employed for multiclass classification. Comparisons are performed with two traditional classification methods, namely, k-Nearest Neighbour (k-NN) and Naive Bayes classifier. It is concluded that SVM-based classifiers outperform the traditional ones in terms of recognition accuracy and robustness property when the original clinical data is distorted with noise. Furthermore, SVM-based classifier with OvO provides the highest recognition accuracy, whereas ANN-based classifier overtakes by demonstrating maximum accuracy in the presence of noise

    The Contribution of Thalamocortical Core and Matrix Pathways to Sleep Spindles.

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    Sleep spindles arise from the interaction of thalamic and cortical neurons. Neurons in the thalamic reticular nucleus (TRN) inhibit thalamocortical neurons, which in turn excite the TRN and cortical neurons. A fundamental principle of anatomical organization of the thalamocortical projections is the presence of two pathways: the diffuse matrix pathway and the spatially selective core pathway. Cortical layers are differentially targeted by these two pathways with matrix projections synapsing in superficial layers and core projections impinging on middle layers. Based on this anatomical observation, we propose that spindles can be classified into two classes, those arising from the core pathway and those arising from the matrix pathway, although this does not exclude the fact that some spindles might combine both pathways at the same time. We find evidence for this hypothesis in EEG/MEG studies, intracranial recordings, and computational models that incorporate this difference. This distinction will prove useful in accounting for the multiple functions attributed to spindles, in that spindles of different types might act on local and widespread spatial scales. Because spindle mechanisms are often hijacked in epilepsy and schizophrenia, the classification proposed in this review might provide valuable information in defining which pathways have gone awry in these neurological disorders
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