The risk of re-intervention after endovascular aortic aneurysm repair

This thesis studies survival analysis techniques dealing with censoring to produce predictive tools that predict the risk of endovascular aortic aneurysm repair (EVAR) re-intervention. Censoring indicates that some patients do not continue follow up, so their outcome class is unknown. Methods dealing with censoring have drawbacks and cannot handle the high censoring of the two EVAR datasets collected. Therefore, this thesis presents a new solution to high censoring by modifying an approach that was incapable of differentiating between risks groups of aortic complications. Feature selection (FS) becomes complicated with censoring. Most survival FS methods depends on Cox's model, however machine learning classifiers (MLC) are preferred. Few methods adopted MLC to perform survival FS, but they cannot be used with high censoring. This thesis proposes two FS methods which use MLC to evaluate features. The two FS methods use the new solution to deal with censoring. They combine factor analysis with greedy stepwise FS search which allows eliminated features to enter the FS process. The first FS method searches for the best neural networks' configuration and subset of features. The second approach combines support vector machines, neural networks, and K nearest neighbor classifiers using simple and weighted majority voting to construct a multiple classifier system (MCS) for improving the performance of individual classifiers. It presents a new hybrid FS process by using MCS as a wrapper method and merging it with the iterated feature ranking filter method to further reduce the features. The proposed techniques outperformed FS methods based on Cox's model such as; Akaike and Bayesian information criteria, and least absolute shrinkage and selector operator in the log-rank test's p-values, sensitivity, and concordance. This proves that the proposed techniques are more powerful in correctly predicting the risk of re-intervention. Consequently, they enable doctors to set patients’ appropriate future observation plan

Variable precision rough set theory decision support system: With an application to bank rating prediction

This dissertation considers, the Variable Precision Rough Sets (VPRS) model, and its development within a comprehensive software package (decision support system), incorporating methods of re sampling and classifier aggregation. The concept of /-reduct aggregation is introduced, as a novel approach to classifier aggregation within the VPRS framework. The software is applied to the credit rating prediction problem, in particularly, a full exposition of the prediction and classification of Fitch's Individual Bank Strength Ratings (FIBRs), to a number of banks from around the world is presented. The ethos of the developed software was to rely heavily on a simple 'point and click' interface, designed to make a VPRS analysis accessible to an analyst, who is not necessarily an expert in the field of VPRS or decision rule based systems. The development of the software has also benefited from consultations with managers from one of Europe's leading hedge funds, who gave valuable insight, advice and recommendations on what they considered as pertinent issues with regards to data mining, and what they would like to see from a modern data mining system. The elements within the developed software reflect each stage of the knowledge discovery process, namely, pre-processing, feature selection, data mining, interpretation and evaluation. The developed software encompasses three software packages, a pre-processing package incorporating some of the latest pre-processing and feature selection methods a VPRS data mining package, based on a novel "vein graph" interface, which presents the analyst with selectable /-reducts over the domain of / and a third more advanced VPRS data mining package, which essentially automates the vein graph interface for incorporation into a re-sampling environment, and also implements the introduced aggregated /-reduct, developed to optimise and stabilise the predictive accuracy of a set of decision rules induced from the aggregated /-reduct