401,079 research outputs found

    Calles y empedrados

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    En número dedicado a: La Alpujarra (Granada

    Las calles de Providence

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    Las calles de Luis González Obregón y algunas otras, en nuestra memoria

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    1 archivo PDF (2 páginas). fhquadragintaReseña para "Caminando por esas calles de Luis González Obregón" de Cecilia Colón La autora, Cecilia Colón, donde se propone un recorrido por ciertas travesías virreinales, tal como éstas fueron recreadas por González Obregón al iniciar la década de 1920, en leyendas incluidas en un libro reeditado muchas veces gracias a su capacidad para plasmar escenarios de un país que ya no existe: Las calles de México. Así, la ciudad novohispana vista a través de los ojos de quien fuera director del Archivo General de la Nación, es observada con minucia en el siglo XXI por la investigadora, quien sitúa al lector en un intersticio entre el pasado y el presente, entre las calles reales y la apropiación ficcional de un narrador bien documentado

    Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

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    A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision-cut slices from Kras-driven non-small-cell lung cancer with varying histopathologies. Unexpectedly, profiling of in situ tumours demonstrated that signalling stratifies mostly according to histopathology, showing enhanced AKT and SRC activity in adenosquamous carcinoma, and mitogen-activated protein kinase (MAPK) activity in adenocarcinoma. In addition, high intertumour and intratumour variability was detected, particularly of MAPK and mammalian target of rapamycin (mTOR) complex 1 activity. Using short-term treatment of slice explants, we showed that cytotoxic responses to combination MAPK and phosphoinositide 3-kinase-mTOR inhibition correlate with the spatially defined activities of both pathways. Thus, whereas genetic drivers determine histopathology spectra, histopathology-associated and spatially variable signalling activities determine drug sensitivity. Our study is in support of spatial aspects of signalling heterogeneity being considered in clinical diagnostic settings, particularly to guide the selection of drug combinations

    Density functional electronic spectrum of the CuO610Cu O_{-6}^{-10} cluster and possible local Jahn-Teller distorsions in the La-Ba-Cu-O superconductor

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    We present a density functional theory (DFT) calculation in the generalized gradient approximation to study the possibility for the existence of Jahn-Teller (JT) or pseudo Jahn-Teller (PJT) type local distortions in the La-Ba-Cu-O superconducting system. We performed the calculation and correspondingly group theory classification of the electronic ground state of the CuO610{_{6}}^{-10} elongated octahedra cluster, immersed in a background simulating the superconductor. Part of the motivation to do this study is that the origin of the apical deformation of the CuO610{_{6}}^{-10} cluster is not due to a pure JT effect, having therefore a non {\it a priori} condition to remove the degeneracy of the electronic ground state of the parent regular octahedron. We present a comparative analysis of the symmetry classified electron spectrum with previously reported results using unrestricted Hartree-Fock calculations (UHF). Both the DFT and UHF calculations produced a non degenerate electronic ground state, not having therefore the necessary condition for a pure JT effect. However, the appearance of a degenerate Eg_{g} state near to the highest occupied molecular orbital in the DFT calculation, suggests the possibility for a PJT effect responsible for a local distortion of the oxidized CuO69_{6}^{-9} cluster.Comment: 12 pages, 3 figures, submitted to International Journal of Modern Physics B (IJMPB

    Ni-based bimetallic heterogeneous catalysts for energy and environmental applications

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    Bimetallic catalysts have attracted extensive attention for a wide range of applications in energy production and environmental remediation due to their tunable chemical/physical properties. These properties are mainly governed by a number of parameters such as compositions of the bimetallic systems, their preparation method, and their morphostructure. In this regard, numerous efforts have been made to develop “designer” bimetallic catalysts with specific nanostructures and surface properties as a result of recent advances in the area of materials chemistry. The present review highlights a detailed overview of the development of nickel-based bimetallic catalysts for energy and environmental applications. Starting from a materials science perspective in order to obtain controlled morphologies and surface properties, with a focus on the fundamental understanding of these bimetallic systems to make a correlation with their catalytic behaviors, a detailed account is provided on the utilization of these systems in the catalytic reactions related to energy production and environmental remediation. We include the entire library of nickel-based bimetallic catalysts for both chemical and electrochemical processes such as catalytic reforming, dehydrogenation, hydrogenation, electrocatalysis and many other reactions

    Violencia doméstica y venta de cosa ajena

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    Traballo fin de grao (UDC.DER). Grao en Dereito. Curso 20125/201

    Las 'calles en el aire'. Paralelismos entre la vida y la arquitectura

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    En 1952 Alison y Peter Smithson entregaron su propuesta para el concurso de viviendas Golden Lane, caracterizado por su diseño de calles peatonales elevadas concebidas como elementos que propiciaran la identificación y sentido de comunidad de sus habitantes. Este proyecto representó una inflexión respecto a sus proyectos anteriores y coincidió con el comienzo de su visión crítica respecto a los postulados funcionalistas de los CIAM precedentes. Con las 'calles en el aire' los Smithson concretaron el primer ejemplo de su propuesta de reorientación del pensamiento urbano mediante una re-identificación que expresaba la actualización de las relaciones entre vida y arquitectura

    Salud mental y suicidio. Terapias artísticas para la prevención del suicidio

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    El siguiente trabajo de fin de grado refleja el estigma que padecen las personas con algún trastorno o algún tipo de enfermedad mental. Hace un recorrido sobre los tipos de trastornos que existen y cómo puede estar relcionado el suicidio con ellos. Trabaja sobre conceptos como la comunicación, el autoestigma, el estigma, el suicidio, el parasuicidio o las tendencias suicidas, la enfermedad mental y los trastornos mentales para explicar cómo es realmente importante la comunicación entre las personas y los beneficios que supone esta, ya sea verbal o no verbal. La figura de el educador social aún no está reconocida con claridad en estos ámbitos, sino que está más relcionado un marco socio terapéutico y sanitario para la recuperación de personas con problemas de salud mental.The following end of degree paper reflects the stigma suffered by people with some disorder or some type of mental illness. It approaches at the types of disorders that exist and how suicide can be relted to them. It focuses on concepts such as communication, self-stigma, stigma, suicide, parasuicide or suicidal tendencies, mental illness and mental disorders to explain how communication among people is really important and the benefits of this, whether verbal or non-verbal. The role of the social educator is not yet clearly recognized in these areas, but it is more relted to a socio-therapeutic and health framework for the recovery of people with mental health problems.Grado en Educación Socia
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