MathMC: A mathematica-based tool for CSL model checking of deterministic and stochastic Petri nets

Deterministic and Stochastic Petri Nets (DSPNs) are a widely used high-level formalism for modeling discreteevent systems where events may occur either without consuming time, after a deterministic time, or after an exponentially distributed time. CSL (Continuous Stochastic Logic) is a (branching) temporal logic developed to express probabilistic properties in continuous time Markov chains (CTMCs). In this paper we present a Mathematica-based tool that implements recent developments for model checking CSL style properties on DSPNs. Furthermore, as a consequence of the type of process underlying DSPNs (a superset of Markovian processes), we are also able to check CSL properties of Generalized Stochastic Petri Nets (GSPNs) and labeled CTMCs

CSL model checking of Deterministic and Stochastic Petri Nets

Deterministic and Stochastic Petri Nets (DSPNs) are a widely used high-level formalism for modeling discrete-event systems where events may occur either without consuming time, after a deterministic time, or after an exponentially distributed time. The underlying process dened by DSPNs, under certain restrictions, corresponds to a class of Markov Regenerative Stochastic Processes (MRGP). In this paper, we investigate the use of CSL (Continuous Stochastic Logic) to express probabilistic properties, such a time-bounded until and time-bounded next, at the DSPN level. The verication of such properties requires the solution of the steady-state and transient probabilities of the underlying MRGP. We also address a number of semantic issues regarding the application of CSL on MRGP and provide numerical model checking algorithms for this logic. A prototype model checker, based on SPNica, is also described

Petri nets for systems and synthetic biology

We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which uni¯es the qualita- tive, stochastic and continuous paradigms. Each perspective adds its con- tribution to the understanding of the system, thus the three approaches do not compete, but complement each other. We illustrate our approach by applying it to an extended model of the three stage cascade, which forms the core of the ERK signal transduction pathway. Consequently our focus is on transient behaviour analysis. We demonstrate how quali- tative descriptions are abstractions over stochastic or continuous descrip- tions, and show that the stochastic and continuous models approximate each other. Although our framework is based on Petri nets, it can be applied more widely to other formalisms which are used to model and analyse biochemical networks

A Monte Carlo model checker for probabilistic LTL with numerical constraints

We define the syntax and semantics of a new temporal logic called probabilistic LTL with numerical constraints (PLTLc). We introduce an efficient model checker for PLTLc properties. The efficiency of the model checker is through approximation using Monte Carlo sampling of finite paths through the model’s state space (simulation outputs) and parallel model checking of the paths. Our model checking method can be applied to any model producing quantitative output – continuous or stochastic, including those with complex dynamics and those with an infinite state space. Furthermore, our offline approach allows the analysis of observed (real-life) behaviour traces. We find in this paper that PLTLc properties with constraints over free variables can replace full model checking experiments, resulting in a significant gain in efficiency. This overcomes one disadvantage of model checking experiments which is that the complexity depends on system granularity and number of variables, and quickly becomes infeasible. We focus on models of biochemical networks, and specifically in this paper on intracellular signalling pathways; however our method can be applied to a wide range of biological as well as technical systems and their models. Our work contributes to the emerging field of synthetic biology by proposing a rigourous approach for the structured formal engineering of biological systems

Analysis of signalling pathways using continuous time Markov chains

We describe a quantitative modelling and analysis approach for signal transduction networks. We illustrate the approach with an example, the RKIP inhibited ERK pathway [CSK+03]. Our models are high level descriptions of continuous time Markov chains: proteins are modelled by synchronous processes and reactions by transitions. Concentrations are modelled by discrete, abstract quantities. The main advantage of our approach is that using a (continuous time) stochastic logic and the PRISM model checker, we can perform quantitative analysis such as what is the probability that if a concentration reaches a certain level, it will remain at that level thereafter? or how does varying a given reaction rate affect that probability? We also perform standard simulations and compare our results with a traditional ordinary differential equation model. An interesting result is that for the example pathway, only a small number of discrete data values is required to render the simulations practically indistinguishable

A model checker for performance and dependability properties

Markov chains are widely used in the context of performance and reliability evaluation of systems of various nature. Model checking of such chains with respect to a given (branching) temporal logic formula has been proposed for both the discrete [8] and the continuous time setting [1], [3]. In this short paper, we describe the prototype model checker $E \vdash M C^2$ for discrete and continuous-time Markov chains, where properties are expressed in appropriate extensions of CTL.We illustrate the general benefits of this approach and discuss the structure of the tool

Model Checking Markov Chains with Actions and State Labels

In the past, logics of several kinds have been proposed for reasoning about discrete- or continuous-time Markov chains. Most of these logics rely on either state labels (atomic propositions) or on transition labels (actions). However, in several applications it is useful to reason about both state-properties and action-sequences. For this purpose, we introduce the logic asCSL which provides powerful means to characterize execution paths of Markov chains with actions and state labels. asCSL can be regarded as an extension of the purely state-based logic asCSL (continuous stochastic logic). \ud In asCSL, path properties are characterized by regular expressions over actions and state-formulas. Thus, the truth value of path-formulas does not only depend on the available actions in a given time interval, but also on the validity of certain state formulas in intermediate states.\ud We compare the expressive power of CSL and asCSL and show that even the state-based fragment of asCSL is strictly more expressive than CSL if time intervals starting at zero are employed. Using an automaton-based technique, an asCSL formula and a Markov chain with actions and state labels are combined into a product Markov chain. For time intervals starting at zero we establish a reduction of the model checking problem for asCSL to CSL model checking on this product Markov chain. The usefulness of our approach is illustrated by through an elaborate model of a scalable cellular communication system for which several properties are formalized by means of asCSL-formulas, and checked using the new procedure

SPDL Model Checking via Property-Driven State Space Generation

In this report we describe how both, memory and time requirements for stochastic model checking of SPDL (stochastic propositional dynamic logic) formulae can significantly be reduced. SPDL is the stochastic extension of the multi-modal program logic PDL.\ud SPDL provides means to specify path-based properties with or without timing restrictions. Paths can be characterised by so-called programs, essentially regular expressions, where the executability can be made dependent on the validity of test formulae. For model-checking SPDL path formulae it is necessary to build a product transition system (PTS)\ud between the system model and the program automaton belonging to the path formula that is to be verified.\ud In many cases, this PTS can be drastically reduced during the model checking procedure, as the program restricts the number of potentially satisfying paths. Therefore, we propose an approach that directly generates the reduced PTS from a given SPA specification and an SPDL path formula.\ud The feasibility of this approach is shown through a selection of case studies, which show enormous state space reductions, at no increase in generation time.\u

A Markov Chain Model Checker

Markov chains are widely used in the context of performance and reliability evaluation of systems of various nature. Model checking of such chains with respect to a given (branching) temporal logic formula has been proposed for both the discrete [17,6] and the continuous time setting [4,8]. In this paper, we describe a prototype model checker for discrete and continuous-time Markov chains, the Erlangen Twente Markov Chain Checker $(E \vdash MC^2$), where properties are expressed in appropriate extensions of CTL. We illustrate the general bene ts of this approach and discuss the structure of the tool. Furthermore we report on first successful applications of the tool to non-trivial examples, highlighting lessons learned during development and application of $(E \vdash MC^2$)

A tool for model-checking Markov chains

Markov chains are widely used in the context of the performance and reliability modeling of various systems. Model checking of such chains with respect to a given (branching) temporal logic formula has been proposed for both discrete [34, 10] and continuous time settings [7, 12]. In this paper, we describe a prototype model checker for discrete and continuous-time Markov chains, the Erlangen-Twente Markov Chain Checker EÎMC2, where properties are expressed in appropriate extensions of CTL. We illustrate the general benefits of this approach and discuss the structure of the tool. Furthermore, we report on successful applications of the tool to some examples, highlighting lessons learned during the development and application of EÎMC2