Comparative analysis of the Λb→Λℓ+ℓ−\Lambda_b \rightarrow \Lambda \ell^+ \ell^- decay in the SM, SUSY and RS model with custodial protection

We comparatively analyze the rare $\Lambda _b\rightarrow \Lambda \ell^+ \ell^-$ channel in standard model, supersymmetry and Randall-Sundrum model with custodial protection (RS$_c$). Using the parametrization of the matrix elements entering the low energy effective Hamiltonian in terms of form factors, we calculate the corresponding differential decay width and lepton forward-backward asymmetry in these models. We compare the results obtained with the most recent data from LHCb as well as lattice QCD results on the considered quantities. It is obtained that the standard model, with the form factors calculated in light-cone QCD sum rules, can not reproduce some experimental data on the physical quantities under consideration but the supersymmetry can do it. The RS$_c$ model predictions are roughly the same as the standard model and there are no considerable differences between the predictions of these two models. In the case of differential decay rate, the data in the range $4$ GeV$^2/$c$^4\leq$ $q^2 \leq 6$ GeV$^2/$c$^4$ can not be described by any of the considered models.Comment: 28 Pages, 12 Figures and 3 Table

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection.

Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies to non-HLA antigens in AMR and allograft injury. Despite the remarkable efforts by leaders in the field who pioneered single antigen bead technology for detection of donor specific antibodies, a considerable amount of work is still needed to better define the antibody attributes that are associated with AMR pathology. This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR)

The use of scanning contactless conductivity detection for the characterisation of stationary phases in micro-fluidic chips

The use of scanning capacitively coupled contactless conductivity detection for the evaluation of the structural homogeneity and density of both packed and monolithic stationary phases in microfluidic chips is presented here for the first time

Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d

Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection. The aim of this study was to assess whether specific molecules from either pathway are excreted into urine and whether they can provide useful diagnostic tools for the monitoring of renal transplant recipients. Methods: Urinary concentrations of soluble adhesion molecules (sICAM-1, sVCAM-1) and of the complement degradation product C4d were determined by standardized ELISA technique in 75 recipients of renal allografts and 29 healthy controls. Patient samples were assigned to four categories according to clinical criteria: group 1: acute steroid-sensitive rejection (ASSR, n=14), group 2: acute steroid-resistant rejection (ASRR, n=12), group 3: chronic allograft dysfunction (CAD, n=20) and group 4: stable graft function (SGF, n=29). Results: All patients with rejection episodes (groups 1-3) had significantly higher values of urinary sC4d compared with healthy controls and patients with stable graft function (p<0.05). The urinary levels of sVCAM-1 were significantly higher in group 2 (ASRR) compared with all other groups (p<0.001). Uniformly low amounts of s-VCAM-1 and complement-split product C4d were excreted by healthy controls (group 0). In contrast, urinary sICAM-1 concentration in healthy controls was almost as high as in group 2 (ASRR) whereas patients with a stable functioning graft (group 4) excreted significantly less sICAM-1 (p<0.05). Conclusion: The evaluation of sVCAM-1 and sC4d excretion in urine can provide a valuable tool with regard to the severity and type of allograft rejection. With respect to long-term allograft survival, serial measurements of these markers should have the potential to detect rejection episodes and prompt immediate treatment. Copyright (C) 2003 S. Karger AG, Basel

N=2\mathcal{N}=2 central charge bounds from 2d2d chiral algebras

We study protected correlation functions in $\mathcal{N} = 2$ SCFT whose description is captured by a two-dimensional chiral algebra. Our analysis implies a new analytic bound for the $c$-anomaly as a function of the flavor central charge $k$, valid for any theory with a flavor symmetry $G$. Combining our result with older bounds in the literature puts strong constraints on the parameter space of $\mathcal{N}=2$ theories. In particular, it singles out a special set of models whose value of $c$ is uniquely fixed once $k$ is given. This set includes the canonical rank one $\mathcal{N}=2$ SCFTs given by Kodaira's classification.Comment: 12 pages, 2 figure

Evaluación del uso de la comunicación para el desarrollo en las intervenciones de conflicto. Medir la paz en la comunicación participativa

The application of Communication for Development (C4D) in conflict prevention, conflict reduction and post-conflict reconstruction interventions is a relatively new field. International organisations that have begun to adopt new communication & media designs in their peace work are progressively offering a credible baseline to engage in the assessment of this practice. In this paper, I offer a short compendium of the evaluation frameworks I have developed through my empirical research on the impact of Communication for Development in Peacebuilding; this is presented alongside a number of reflections and followed by concluding considerations on the state of the field.La aplicación de la Comunicación para el Desarrollo (C4D) en la prevención y reducción de conflictos, así como en la intervención para la reconstrucción cuando estos no pueden ser evitados, es un campo relativamente nuevo. Las organizaciones internacionales que han rediseñado su comunicación y medios en su trabajo para la consecución de la paz nos están ofreciendo de forma progresiva una base de referencia fiable para participar en la evaluación de esta práctica. En este trabajo presento un breve compendio de los marcos de evaluación que he desarrollado a través de mi investigación empírica sobre el impacto de la Comunicación para el Desarrollo en la consolidación de la Paz; un estudio que viene acompañado de una serie de reflexiones y seguido por unas conclusiones finales sobre el estado en el que este campo se encuentra en la actualidad

Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection

Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses. We demonstrate the application of electrophoresis microchips with capacitively-coupled contactless conductivity detection (C4D) to the analysis of wa-ter-soluble vitamins and metal cations in raw material solutions that are subse-quently fed into bioreactors for the production of biologics

The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions.

The 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection (AMR) and small vessel arteriopathy. Specific topics included the strengths and limitations of the current rejection grading system, the central role of microvascular injury in AMR and approaches to semiquantitative assessment of histopathologic and immunophenotypic indicators, the role of AMR in the development of cardiac allograft vasculopathy, the important role of serologic antibody detection in the management of transplant recipients, and the potential application of new molecular approaches to the elucidation of the pathophysiology of AMR and potential for improving the current diagnostic system. Herein we summarize the key points from the presentations, the comprehensive, open and wide-ranging multidisciplinary discussion that was generated, and considerations for future endeavors

Universal RG Flows Across Dimensions and Holography

We study RG flows between superconformal field theories living in different spacetime dimensions which exhibit universal properties, independent of the details of the UV and IR theories. In particular, when the UV and IR theories are both even-dimensional we establish exact universal relations between their conformal anomaly coefficients. We also provide strong evidence for similar relations between appropriately defined free energies for RG flows between odd-dimensional theories in the large $N$ limit. Holographically, these RG flows across dimensions are described by asymptotically AdS black branes in a gauged supergravity theory, which we exhibit explicitly. We also discuss the uplift of these solutions to string and M-theory and comment on how the entropy of such black branes is captured by the dual field theory.Comment: 64 pages, 2 figures; v2: additional comments and references, typos fixe