Anytime Cognition: An information agent for emergency response

Planning under pressure in time-constrained environments while relying on uncertain information is a challenging task. This is particularly true for planning the response during an ongoing disaster in a urban area, be that a natural one, or a deliberate attack on the civilian population. As the various activities pertaining to the emergency response need to be coordinated in response to multiple reports from the disaster site, a user finds itself cognitively overloaded. To address this issue, we designed the Anytime Cognition (ANTICO) concept to assist human users working in time-constrained environments by maintaining a manageable level of cognitive workload over time. Based on the ANTICO concept, we develop an agent framework for proactively managing a user’s changing information requirements by integrating information management techniques with probabilistic plan recognition. In this paper, we describe a prototype emergency response application in the context of a subset of the attacks devised by the American Department of Homeland Security

High-throughput Binding Affinity Calculations at Extreme Scales

Resistance to chemotherapy and molecularly targeted therapies is a major factor in limiting the effectiveness of cancer treatment. In many cases, resistance can be linked to genetic changes in target proteins, either pre-existing or evolutionarily selected during treatment. Key to overcoming this challenge is an understanding of the molecular determinants of drug binding. Using multi-stage pipelines of molecular simulations we can gain insights into the binding free energy and the residence time of a ligand, which can inform both stratified and personal treatment regimes and drug development. To support the scalable, adaptive and automated calculation of the binding free energy on high-performance computing resources, we introduce the High- throughput Binding Affinity Calculator (HTBAC). HTBAC uses a building block approach in order to attain both workflow flexibility and performance. We demonstrate close to perfect weak scaling to hundreds of concurrent multi-stage binding affinity calculation pipelines. This permits a rapid time-to-solution that is essentially invariant of the calculation protocol, size of candidate ligands and number of ensemble simulations. As such, HTBAC advances the state of the art of binding affinity calculations and protocols

A cognitive architecture for emergency response

Plan recognition, cognitive workload estimation and human assistance have been extensively studied in the AI and human factors communities, resulting in many techniques being applied to domains of various levels of realism. These techniques have seldom been integrated and evaluated as complete systems. In this paper, we report on the development of an assistant agent architecture that integrates plan recognition, current and future user information needs, workload estimation and adaptive information presentation to aid an emergency response manager in making high quality decisions under time stress, while avoiding cognitive overload. We describe the main components of a full implementation of this architecture as well as a simulation developed to evaluate the system. Our evaluation consists of simulating various possible executions of the emergency response plans used in the real world and measuring the expected time taken by an unaided human user, as well as one that receives information assistance from our system. In the experimental condition of agent assistance, we also examine the effects of different error rates in the agent's estimation of user's stat or information needs

Business Process Redesign in the Perioperative Process: A Case Perspective for Digital Transformation

This case study investigates business process redesign within the perioperative process as a method to achieve digital transformation. Specific perioperative sub-processes are targeted for re-design and digitalization, which yield improvement. Based on a 184-month longitudinal study of a large 1,157 registered-bed academic medical center, the observed effects are viewed through a lens of information technology (IT) impact on core capabilities and core strategy to yield a digital transformation framework that supports patient-centric improvement across perioperative sub-processes. This research identifies existing limitations, potential capabilities, and subsequent contextual understanding to minimize perioperative process complexity, target opportunity for improvement, and ultimately yield improved capabilities. Dynamic technological activities of analysis, evaluation, and synthesis applied to specific perioperative patient-centric data collected within integrated hospital information systems yield the organizational resource for process management and control. Conclusions include theoretical and practical implications as well as study limitations

E-finance-lab at the House of Finance : about us

The financial services industry is believed to be on the verge of a dramatic [r]evolution. A substantial redesign of its value chains aimed at reducing costs, providing more efficient and flexible services and enabling new products and revenue streams is imminent. But there seems to be no clear migration path nor goal which can cast light on the question where the finance industry and its various players will be and should be in a decade from now. The mission of the E-Finance Lab is the development and application of research methodologies in the financial industry that promote and assess how business strategies and structures are shared and supported by strategies and structures of information systems. Important challenges include the design of smart production infrastructures, the development and evaluation of advantageous sourcing strategies and smart selling concepts to enable new revenue streams for financial service providers in the future. Overall, our goal is to contribute methods and views to the realignment of the E-Finance value chain. ..