23,132 research outputs found
A 3D Coarse-to-Fine Framework for Volumetric Medical Image Segmentation
In this paper, we adopt 3D Convolutional Neural Networks to segment
volumetric medical images. Although deep neural networks have been proven to be
very effective on many 2D vision tasks, it is still challenging to apply them
to 3D tasks due to the limited amount of annotated 3D data and limited
computational resources. We propose a novel 3D-based coarse-to-fine framework
to effectively and efficiently tackle these challenges. The proposed 3D-based
framework outperforms the 2D counterpart to a large margin since it can
leverage the rich spatial infor- mation along all three axes. We conduct
experiments on two datasets which include healthy and pathological pancreases
respectively, and achieve the current state-of-the-art in terms of
Dice-S{\o}rensen Coefficient (DSC). On the NIH pancreas segmentation dataset,
we outperform the previous best by an average of over 2%, and the worst case is
improved by 7% to reach almost 70%, which indicates the reliability of our
framework in clinical applications.Comment: 9 pages, 4 figures, Accepted to 3D
WPU-Net: Boundary Learning by Using Weighted Propagation in Convolution Network
Deep learning has driven a great progress in natural and biological image
processing. However, in material science and engineering, there are often some
flaws and indistinctions in material microscopic images induced from complex
sample preparation, even due to the material itself, hindering the detection of
target objects. In this work, we propose WPU-net that redesigns the
architecture and weighted loss of U-Net, which forces the network to integrate
information from adjacent slices and pays more attention to the topology in
boundary detection task. Then, the WPU-net is applied into a typical material
example, i.e., the grain boundary detection of polycrystalline material.
Experiments demonstrate that the proposed method achieves promising performance
and outperforms state-of-the-art methods. Besides, we propose a new method for
object tracking between adjacent slices, which can effectively reconstruct 3D
structure of the whole material. Finally, we present a material microscopic
image dataset with the goal of advancing the state-of-the-art in image
processing for material science.Comment: technical repor
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A Rapid Segmentation-Insensitive "Digital Biopsy" Method for Radiomic Feature Extraction: Method and Pilot Study Using CT Images of Non-Small Cell Lung Cancer.
Quantitative imaging approaches compute features within images' regions of interest. Segmentation is rarely completely automatic, requiring time-consuming editing by experts. We propose a new paradigm, called "digital biopsy," that allows for the collection of intensity- and texture-based features from these regions at least 1 order of magnitude faster than the current manual or semiautomated methods. A radiologist reviewed automated segmentations of lung nodules from 100 preoperative volume computed tomography scans of patients with non-small cell lung cancer, and manually adjusted the nodule boundaries in each section, to be used as a reference standard, requiring up to 45 minutes per nodule. We also asked a different expert to generate a digital biopsy for each patient using a paintbrush tool to paint a contiguous region of each tumor over multiple cross-sections, a procedure that required an average of <3 minutes per nodule. We simulated additional digital biopsies using morphological procedures. Finally, we compared the features extracted from these digital biopsies with our reference standard using intraclass correlation coefficient (ICC) to characterize robustness. Comparing the reference standard segmentations to our digital biopsies, we found that 84/94 features had an ICC >0.7; comparing erosions and dilations, using a sphere of 1.5-mm radius, of our digital biopsies to the reference standard segmentations resulted in 41/94 and 53/94 features, respectively, with ICCs >0.7. We conclude that many intensity- and texture-based features remain consistent between the reference standard and our method while substantially reducing the amount of operator time required
Segmentation of the left ventricle of the heart in 3-D+t MRI data using an optimized nonrigid temporal model
Modern medical imaging modalities provide large amounts of information in both the spatial and temporal domains and the incorporation of this information in a coherent algorithmic framework is a significant challenge. In this paper, we present a novel and intuitive approach to combine 3-D spatial and temporal (3-D + time) magnetic resonance imaging (MRI) data in an integrated segmentation algorithm to extract the myocardium of the left ventricle. A novel level-set segmentation process is developed that simultaneously delineates and tracks the boundaries of the left ventricle muscle. By encoding prior knowledge about cardiac temporal evolution in a parametric framework, an expectation-maximization algorithm optimally tracks the myocardial deformation over the cardiac cycle. The expectation step deforms the level-set function while the maximization step updates the prior temporal model parameters to perform the segmentation in a nonrigid sense
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
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