Identifying Parkinson’s Patients: A Functional Gradient Boosting Approach

Parkinson’s, a progressive neural disorder, is difficult to identify due to the hidden nature of the symptoms associated. We present a machine learning approach that uses a definite set of features obtained from the Parkinson’s Progression Markers Initiative (PPMI) study as input and classifies them into one of two classes: PD (Parkinson’s disease) and HC (Healthy Control). As far as we know this is the first work in applying machine learning algorithms for classifying patients with Parkinson’s disease with the involvement of domain expert during the feature selection process. We evaluate our approach on 1194 patients acquired from Parkinson’s Progression Markers Initiative and show that it achieves a state-of-the-art performance with minimal feature engineering

VAT tax gap prediction: a 2-steps Gradient Boosting approach

Tax evasion is the illegal evasion of taxes by individuals, corporations, and trusts. The revenue loss from tax avoidance can undermine the effectiveness and equity of the government policies. A standard measure of tax evasion is the tax gap, that can be estimated as the difference between the total amounts of tax theoretically collectable and the total amounts of tax actually collected in a given period. This paper presents an original contribution to bottom-up approach, based on results from fiscal audits, through the use of Machine Learning. The major disadvantage of bottom-up approaches is represented by selection bias when audited taxpayers are not randomly selected, as in the case of audits performed by the Italian Revenue Agency. Our proposal, based on a 2-steps Gradient Boosting model, produces a robust tax gap estimate and, embeds a solution to correct for the selection bias which do not require any assumptions on the underlying data distribution. The 2-steps Gradient Boosting approach is used to estimate the Italian Value-added tax (VAT) gap on individual firms on the basis of fiscal and administrative data income tax returns gathered from Tax Administration Data Base, for the fiscal year 2011. The proposed method significantly boost the performance in predicting with respect to the classical parametric approaches.Comment: 27 pages, 4 figures, 8 tables Presented at NTTS 2019 conference Under review at another peer-reviewed journa

Machine learning-guided synthesis of advanced inorganic materials

Synthesis of advanced inorganic materials with minimum number of trials is of paramount importance towards the acceleration of inorganic materials development. The enormous complexity involved in existing multi-variable synthesis methods leads to high uncertainty, numerous trials and exorbitant cost. Recently, machine learning (ML) has demonstrated tremendous potential for material research. Here, we report the application of ML to optimize and accelerate material synthesis process in two representative multi-variable systems. A classification ML model on chemical vapor deposition-grown MoS2 is established, capable of optimizing the synthesis conditions to achieve higher success rate. While a regression model is constructed on the hydrothermal-synthesized carbon quantum dots, to enhance the process-related properties such as the photoluminescence quantum yield. Progressive adaptive model is further developed, aiming to involve ML at the beginning stage of new material synthesis. Optimization of the experimental outcome with minimized number of trials can be achieved with the effective feedback loops. This work serves as proof of concept revealing the feasibility and remarkable capability of ML to facilitate the synthesis of inorganic materials, and opens up a new window for accelerating material development