Identification of Diabetic Retinopathy in Retinal Images using Support Vector Machine

Abstract -Retinal vessel segmentation algorithms are a fundamental component of automatic retinal disease screening systems. It helps in not only detecting the retinal diseases but also can help to recover that disease in time like diabetic retinopathy, retinopathy of prematurity (ROP) etc. Supervised Retinal vessel segmentation algorithms are most widely research and studied by researcher. As more research work is published on supervised algorithm we are decided to work on this paper. In this work we are simply examines the supervised blood vessel segmentation methodologies in two dimensional retinal images acquired from a fundus camera along with a survey along with provide the most of the databases which are locally present for this work. The aim of this paper is to review and analyze the supervised retinal vessel extraction algorithms, techniques and methodologies, giving a brief description, highlighting the key points and the performance measures given by the different authors in systematic form. We trying to provide the reader a framework for the existing research; to introduce the all supervised retinal vessel segmentation algorithms along with databases which are locally present over for work and future directions and summarize the survey. The performance of algorithms is compared and analyzed on two publicly available databases (DRIVE and STARE) of retinal images using a number of measures which include accuracy, true positive rate, false positive rate, sensitivity, specificity and area under receiver operating characteristic (ROC) curve

Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models

The health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to generate detailed 3D images of blood vessels that could contribute to our understanding of the role of vascular structure in normal physiology and in disease mechanisms. The segmentation of vessels, a core image analysis problem, is a bottleneck that has prevented the systematic comparison of 3D vascular architecture across experimental populations. We explored the use of convolutional neural networks to segment 3D vessels within volumetric in vivo images acquired by multiphoton microscopy. We evaluated different network architectures and machine learning techniques in the context of this segmentation problem. We show that our optimized convolutional neural network architecture, which we call DeepVess, yielded a segmentation accuracy that was better than both the current state-of-the-art and a trained human annotator, while also being orders of magnitude faster. To explore the effects of aging and Alzheimer's disease on capillaries, we applied DeepVess to 3D images of cortical blood vessels in young and old mouse models of Alzheimer's disease and wild type littermates. We found little difference in the distribution of capillary diameter or tortuosity between these groups, but did note a decrease in the number of longer capillary segments ($>75\mu m$) in aged animals as compared to young, in both wild type and Alzheimer's disease mouse models.Comment: 34 pages, 9 figure