Recent advances in 3D printing of biomaterials.

3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. In this review, the major materials and technology advances within the last five years for each of the common 3D Printing technologies (Three Dimensional Printing, Fused Deposition Modeling, Selective Laser Sintering, Stereolithography, and 3D Plotting/Direct-Write/Bioprinting) are described. Examples are highlighted to illustrate progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing

Radar and RGB-depth sensors for fall detection: a review

This paper reviews recent works in the literature on the use of systems based on radar and RGB-Depth (RGB-D) sensors for fall detection, and discusses outstanding research challenges and trends related to this research field. Systems to detect reliably fall events and promptly alert carers and first responders have gained significant interest in the past few years in order to address the societal issue of an increasing number of elderly people living alone, with the associated risk of them falling and the consequences in terms of health treatments, reduced well-being, and costs. The interest in radar and RGB-D sensors is related to their capability to enable contactless and non-intrusive monitoring, which is an advantage for practical deployment and users’ acceptance and compliance, compared with other sensor technologies, such as video-cameras, or wearables. Furthermore, the possibility of combining and fusing information from The heterogeneous types of sensors is expected to improve the overall performance of practical fall detection systems. Researchers from different fields can benefit from multidisciplinary knowledge and awareness of the latest developments in radar and RGB-D sensors that this paper is discussing

A first approach to a taxonomy-based classification framework for hand grasps

Many solutions have been proposed to help amputated subjects regain the lost functionality. In order to interact with the outer world and objects that populate it, it is crucial for these subjects to being able to perform essential grasps. In this paper we propose a preliminary solution for the online classification of 8 basics hand grasps by considering physiological signals, namely Surface Electromyography (sEMG), exploiting a quantitative taxonomy of the considered movement. The hierarchical organization of the taxonomy allows a decomposition of the classification phase between couples of movement groups. The idea is that the closest to the roots the more hard is the classification, but on the meantime the miss-classification error is less problematic, since the two movements will be close to each other. The proposed solution is subject-independent, which means that signals from many different subjects are considered by the probabilistic framework to modelize the input signals. The information has been modeled offline by using a Gaussian Mixture Model (GMM), and then testen online on a unseen subject, by using a Gaussian-based classification. In order to be able to process the signal online, an accurate preprocessing phase is needed, in particular, we apply the Wavelet Transform (Wavelet Transform) to the Electromyography (EMG) signal. Thanks to this approach we are able to develop a robust and general solution, which can adapt quickly to new subjects, with no need of long and draining training phase. In this preliminary study we were able to reach a mean accuracy of 76.5%, reaching up to 97.29% in the higher levels

Optimization of Enzymatic Logic Gates and Networks for Noise Reduction and Stability

Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemical logic gates based on enzymatic reactions, and a network of three gates, for reduction of the "analog" noise buildup. For a single gate, optimization is achieved by analyzing the enzymatic reactions within a framework of kinetic equations. We demonstrate that using co-substrates with much smaller affinities than the primary substrate, a negligible increase in the noise output from the logic gate is obtained as compared to the input noise. A network of enzymatic gates is analyzed by varying selective inputs and fitting standardized few-parameters response functions assumed for each gate. This allows probing of the individual gate quality but primarily yields information on the relative contribution of the gates to noise amplification. The derived information is then used to modify experimental single gate and network systems to operate them in a regime of reduced analog noise amplification.Comment: 7 pages in PD

Modeling and evolving biochemical networks: insights into communication and computation from the biological domain

This paper is concerned with the modeling and evolving of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities. We examine the possibility to computationally evolve and simulate Artificial Cell Signaling Networks (ACSNs) by means of Evolutionary Computation techniques. From a practical point of view, realizing and evolving ACSNs may provide novel computational paradigms for a variety of application areas. For example, understanding some inherent properties of CSNs such as crosstalk may be of interest: A potential benefit of engineering crosstalking systems is that it allows the modification of a specific process according to the state of other processes in the system. This is clearly necessary in order to achieve complex control tasks. This work may also contribute to the biological understanding of the origins and evolution of real CSNs. An introduction to CSNs is first provided, in which we describe the potential applications of modeling and evolving these biochemical networks in silico. We then review the different classes of techniques to model CSNs, this is followed by a presentation of two alternative approaches employed to evolve CSNs within the ESIGNET project. Results obtained with these methods are summarized and discussed

Mathematical modeling of ultra wideband in vivo radio channel

This paper proposes a novel mathematical model for an in vivo radio channel at ultra-wideband frequencies (3.1–10.6 GHz), which can be used as a reference model for in vivo channel response without performing intensive experiments or simulations. The statistics of error prediction between experimental and proposed model is RMSE = 5.29, which show the high accuracy of the proposed model. Also, the proposed model was applied to the blind data, and the statistics of error prediction is RMSE = 7.76, which also shows a reasonable accuracy of the model. This model will save the time and cost on simulations and experiments, and will help in designing an accurate link budget calculation for a future enhanced system for ultra-wideband body-centric wireless systems