BIO-EFFECTS OF AIRCRAFT NOISE AND ANTIOXIDANT ACTIVITY OF OMEGA3 ON MICE BRAIN

In order to investigate the non-auditory bio-effects of aircraft noise exposure on brain, mice in soundproof chambers were exposed to a previously recorded aircraft-related noise signal for a duration of 1,2 or 3 weeks. For comparison, unexposed control mice have been used. The work plan includes aircraft takeoff and landing noise which adjusted to a level of 100 dB forthe 4 experimental groups for 2 hours daily. The recorded noise was analyzed using Audacity software program. The levels of blood glucose and cortisol in serum were measured. Morphological changes of brain tissue were observed by light microscope. The results showed that, Takeoff frequency ranged from 3-4 KHz at 100dB, while dominant frequency for landing was 2-3 KHz. Noise of 100 dB was found to cause significant increases in plasma glucose and cortisol for exposed mice as compared to no noise exposure. Administration of omega 3 for three weeks causes a significant improvement in plasma glucose and cortisol. Histopathological changes in brain of mice exposed to aircraft noise revealed some vesicles and mild to moderate apoptosis and pyknosis of the nuclei. In conclusion the present study determined that high intensity noise has a direct and clear effect on physical, biochemical values and thus noise exposure should be well organized