Which Learning Algorithms Can Generalize Identity-Based Rules to Novel Inputs?

We propose a novel framework for the analysis of learning algorithms that allows us to say when such algorithms can and cannot generalize certain patterns from training data to test data. In particular we focus on situations where the rule that must be learned concerns two components of a stimulus being identical. We call such a basis for discrimination an identity-based rule. Identity-based rules have proven to be difficult or impossible for certain types of learning algorithms to acquire from limited datasets. This is in contrast to human behaviour on similar tasks. Here we provide a framework for rigorously establishing which learning algorithms will fail at generalizing identity-based rules to novel stimuli. We use this framework to show that such algorithms are unable to generalize identity-based rules to novel inputs unless trained on virtually all possible inputs. We demonstrate these results computationally with a multilayer feedforward neural network.Comment: 6 pages, accepted abstract at COGSCI 201

Endoscopic laser-ablation for the treatment of orthotopic and ectopic ureteroceles in dogs: 13 cases (2008-2017).

BACKGROUND: Ureteroceles are a rare condition in dogs in which conventional treatments can result in substantial morbidity. Cystoscopic and fluoroscopic-guided laser ablation (CLA) of ureteroceles can successfully relieve obstruction. OBJECTIVES: To describe the technique and outcomes of attempting CLA for treatment of ureteroceles in dogs. ANIMALS: Thirteen client-owned dogs that underwent CLA for treatment of ureteroceles. METHODS: Retrospective multicentered study. Medical records were reviewed in all dogs that underwent CLA for ureterocele(s). A laser was used to extend the opening of the ureteral orifice (UO) unless surgical conversion was necessary. Data collected included signalment, clinicopathologic data, imaging, procedural findings, complications, and short- and long-term outcome. RESULTS: Thirteen dogs with 13 ureteroceles associated with 14 UOs resulting in ureteral obstruction were included. One ureterocele extended bilaterally. Treatment was initiated via retrograde cystoscopy (7 females), percutaneous perineal urethrocystoscopy (4 males), or percutaneous antegrade cystoscopy (2 males). Surgical conversion was necessary in 2 males. Ten of 14 (71%) UOs associated with the ureteroceles were ectopic. Thirteen of 14 had stenotic or imperforate UOs. No postoperative complications were noted. Preoperative incontinence or pollakiuria was present in 9 of 13 and 3 of 13 dogs and resolved in 8 of 9 and 3 of 3 dogs, respectively. Follow-up imaging showed resolution of all ureteroceles and improved ureteral/renal pelvic dilatation. Median follow-up time was 27 months (range, 3-96 months). CONCLUSIONS AND CLINICAL IMPORTANCE: Cystoscopic-guided laser ablation was effective for the treatment of ureteroceles(s) in 11 of 13 dogs

The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2).

Cell number in the mouse thymus increases steadily during the first two weeks after birth. It then plateaus and begins to decline by seven weeks after birth. The factors governing these dramatic changes in cell production are not well understood. The data herein correlate levels of High mobility group A 2 protein (Hmga2) expression with these temporal changes in thymopoiesis. Hmga2 is expressed at high levels in murine fetal and neonatal early T cell progenitors (ETP), which are the most immature intrathymic precursors, and becomes almost undetectable in these progenitors after 5 weeks of age. Hmga2 expression is critical for the initial, exponential expansion of thymopoiesis, as Hmga2 deficient mice have a deficit of ETPs within days after birth, and total thymocyte number is repressed compared to wild type littermates. Finally, our data raise the possibility that similar events occur in humans, because Hmga2 expression is high in human fetal thymic progenitors and falls in these cells during early infancy

Coherent multi-dimensional segmentation of multiview images using a variational framework and applications to image based rendering

Image Based Rendering (IBR) and in particular light field rendering has attracted a lot of attention for interpolating new viewpoints from a set of multiview images. New images of a scene are interpolated directly from nearby available ones, thus enabling a photorealistic rendering. Sampling theory for light fields has shown that exact geometric information in the scene is often unnecessary for rendering new views. Indeed, the band of the function is approximately limited and new views can be rendered using classical interpolation methods. However, IBR using undersampled light fields suffers from aliasing effects and is difficult particularly when the scene has large depth variations and occlusions. In order to deal with these cases, we study two approaches: New sampling schemes have recently emerged that are able to perfectly reconstruct certain classes of parametric signals that are not bandlimited but characterized by a finite number of parameters. In this context, we derive novel sampling schemes for piecewise sinusoidal and polynomial signals. In particular, we show that a piecewise sinusoidal signal with arbitrarily high frequencies can be exactly recovered given certain conditions. These results are applied to parametric multiview data that are not bandlimited. We also focus on the problem of extracting regions (or layers) in multiview images that can be individually rendered free of aliasing. The problem is posed in a multidimensional variational framework using region competition. In extension to previous methods, layers are considered as multi-dimensional hypervolumes. Therefore the segmentation is done jointly over all the images and coherence is imposed throughout the data. However, instead of propagating active hypersurfaces, we derive a semi-parametric methodology that takes into account the constraints imposed by the camera setup and the occlusion ordering. The resulting framework is a global multi-dimensional region competition that is consistent in all the images and efficiently handles occlusions. We show the validity of the approach with captured light fields. Other special effects such as augmented reality and disocclusion of hidden objects are also demonstrated

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight

We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock study. The clinical course of the dogs was dramatic including anorexia and hemolytic anemia. Treatment included allogeneic transfusion, prednisone, and oxytetracycline. Systematic follow-up (n=12, blood smears, antibody testing and specific polymerase chain reaction) gives clear evidence that persistent eradication of M. haemocanis is unlikely. We, therefore, had to abandon the intended shock study. In the absence of effective surveillance and screening for M. haemocanis, the question arises whether it is prudent to continue shock research in splenectomized dogs. Copyright (C) 2004 S. Karger AG, Basel

Early tumor response to intraarterial or intravenous administration of carboplatin to treat naturally occurring lower urinary tract carcinoma in dogs.

BackgroundSurvival times and tumor responses associated with malignant neoplasia of the lower urinary tract are poor despite the vast array of current treatments. Therefore, the evaluation of alternative treatments, such as intraarterial administration of chemotherapy (IAC) should be considered.ObjectiveTo describe a technique for superselective catheterization for IAC and to evaluate initial tumor response by ultrasonography after both IAC and intravenous administration of chemotherapy (IVC).AnimalsClient-owned dogs with lower urinary tract neoplasia treated with either IVC (n = 15) or IAC (n = 11).MethodsRetrospective study. An arterial approach via the carotid or femoral artery was utilized to obtain superselective access and administer chemotherapy in the IAC cases. Medical record review was performed, data were recorded, and recorded variables were evaluated statistically.ResultsIntraarterial chemotherapy was successfully administered in all cases. There was a significantly greater decrease in longest unidimensional measurement in the IAC group as compared to the IVC group (P = .013). The IAC group was also significantly more likely to have a tumor response as assessed by modified RECIST guidelines (P = .049). Dogs in the IAC group were significantly less likely to develop anemia (P = .001), lethargy (P = .010) and anorexia (P = .024).Conclusion and clinical importanceThis study demonstrated the feasibility and efficacy of performing IAC for lower urinary tract neoplasia. Further investigation is necessary as the follow-up time was short and the impact on long-term outcome and survival was not determined

Social capital and collusion: the case of merchant guilds

Merchant guilds have been portrayed as ‘social networks’ that generated beneficial ‘social capital’ by sustaining shared norms, effectively transmitting information, and successfully undertaking collective action. This social capital, it is claimed, benefited society as a whole by enabling rulers to commit to providing a secure trading environment for alien merchants. But was this really the case? We develop a new model of the emergence, rise and eventual decline of European merchant guilds which explores the collusive relationship between rulers and guilds, and calls into question the prevailing positive view of merchant guilds. We then confront the model’s predictions with the available historical data. The empirical evidence strongly support our model and refutes existing theories. Our findings show that merchant guilds used their social capital for socially harmful as well as beneficial ends