35,353 research outputs found
PYRO-NN: Python Reconstruction Operators in Neural Networks
Purpose: Recently, several attempts were conducted to transfer deep learning
to medical image reconstruction. An increasingly number of publications follow
the concept of embedding the CT reconstruction as a known operator into a
neural network. However, most of the approaches presented lack an efficient CT
reconstruction framework fully integrated into deep learning environments. As a
result, many approaches are forced to use workarounds for mathematically
unambiguously solvable problems. Methods: PYRO-NN is a generalized framework to
embed known operators into the prevalent deep learning framework Tensorflow.
The current status includes state-of-the-art parallel-, fan- and cone-beam
projectors and back-projectors accelerated with CUDA provided as Tensorflow
layers. On top, the framework provides a high level Python API to conduct FBP
and iterative reconstruction experiments with data from real CT systems.
Results: The framework provides all necessary algorithms and tools to design
end-to-end neural network pipelines with integrated CT reconstruction
algorithms. The high level Python API allows a simple use of the layers as
known from Tensorflow. To demonstrate the capabilities of the layers, the
framework comes with three baseline experiments showing a cone-beam short scan
FDK reconstruction, a CT reconstruction filter learning setup, and a TV
regularized iterative reconstruction. All algorithms and tools are referenced
to a scientific publication and are compared to existing non deep learning
reconstruction frameworks. The framework is available as open-source software
at \url{https://github.com/csyben/PYRO-NN}. Conclusions: PYRO-NN comes with the
prevalent deep learning framework Tensorflow and allows to setup end-to-end
trainable neural networks in the medical image reconstruction context. We
believe that the framework will be a step towards reproducible researchComment: V1: Submitted to Medical Physics, 11 pages, 7 figure
Recommended from our members
IMRT QA using machine learning: A multi-institutional validation.
PurposeTo validate a machine learning approach to Virtual intensity-modulated radiation therapy (IMRT) quality assurance (QA) for accurately predicting gamma passing rates using different measurement approaches at different institutions.MethodsA Virtual IMRT QA framework was previously developed using a machine learning algorithm based on 498 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3 mm with 10% threshold at Institution 1. An independent set of 139 IMRT measurements from a different institution, Institution 2, with QA data based on portal dosimetry using the same gamma index, was used to test the mathematical framework. Only pixels with ≥10% of the maximum calibrated units (CU) or dose were included in the comparison. Plans were characterized by 90 different complexity metrics. A weighted poison regression with Lasso regularization was trained to predict passing rates using the complexity metrics as input.ResultsThe methodology predicted passing rates within 3% accuracy for all composite plans measured using diode-array detectors at Institution 1, and within 3.5% for 120 of 139 plans using portal dosimetry measurements performed on a per-beam basis at Institution 2. The remaining measurements (19) had large areas of low CU, where portal dosimetry has a larger disagreement with the calculated dose and as such, the failure was expected. These beams need further modeling in the treatment planning system to correct the under-response in low-dose regions. Important features selected by Lasso to predict gamma passing rates were as follows: complete irradiated area outline (CIAO), jaw position, fraction of MLC leafs with gaps smaller than 20 or 5 mm, fraction of area receiving less than 50% of the total CU, fraction of the area receiving dose from penumbra, weighted average irregularity factor, and duty cycle.ConclusionsWe have demonstrated that Virtual IMRT QA can predict passing rates using different measurement techniques and across multiple institutions. Prediction of QA passing rates can have profound implications on the current IMRT process
- …