Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

A Double Joint Bayesian Approach for J-Vector Based Text-dependent Speaker Verification

J-vector has been proved to be very effective in text-dependent speaker verification with short-duration speech. However, the current state-of-the-art back-end classifiers, e.g. joint Bayesian model, cannot make full use of such deep features. In this paper, we generalize the standard joint Bayesian approach to model the multi-faceted information in the j-vector explicitly and jointly. In our generalization, the j-vector was modeled as a result derived by a generative Double Joint Bayesian (DoJoBa) model, which contains several kinds of latent variables. With DoJoBa, we are able to explicitly build a model that can combine multiple heterogeneous information from the j-vectors. In verification step, we calculated the likelihood to describe whether the two j-vectors having consistent labels or not. On the public RSR2015 data corpus, the experimental results showed that our approach can achieve 0.02\% EER and 0.02\% EER for impostor wrong and impostor correct cases respectively

One-Class Classification: Taxonomy of Study and Review of Techniques

One-class classification (OCC) algorithms aim to build classification models when the negative class is either absent, poorly sampled or not well defined. This unique situation constrains the learning of efficient classifiers by defining class boundary just with the knowledge of positive class. The OCC problem has been considered and applied under many research themes, such as outlier/novelty detection and concept learning. In this paper we present a unified view of the general problem of OCC by presenting a taxonomy of study for OCC problems, which is based on the availability of training data, algorithms used and the application domains applied. We further delve into each of the categories of the proposed taxonomy and present a comprehensive literature review of the OCC algorithms, techniques and methodologies with a focus on their significance, limitations and applications. We conclude our paper by discussing some open research problems in the field of OCC and present our vision for future research.Comment: 24 pages + 11 pages of references, 8 figure