Configuration of Distributed Message Converter Systems using Performance Modeling

To find a configuration of a distributed system satisfying performance goals is a complex search problem that involves many design parameters, like hardware selection, job distribution and process configuration. Performance models are a powerful tools to analyse potential system configurations, however, their evaluation is expensive, such that only a limited number of possible configurations can be evaluated. In this paper we present a systematic method to find a satisfactory configuration with feasible effort, based on a two-step approach. First, using performance estimates a hardware configuration is determined and then the software configuration is incrementally optimized evaluating Layered Queueing Network models. We applied this method to the design of performant EDI converter systems in the financial domain, where increasing message volumes need to be handled due to the increasing importance of B2B interaction

Load Balancing and Virtual Machine Allocation in Cloud-based Data Centers

As cloud services see an exponential increase in consumers, the demand for faster processing of data and a reliable delivery of services becomes a pressing concern. This puts a lot of pressure on the cloud-based data centers, where the consumers’ data is stored, processed and serviced. The rising demand for high quality services and the constrained environment, make load balancing within the cloud data centers a vital concern. This project aims to achieve load balancing within the data centers by means of implementing a Virtual Machine allocation policy, based on consensus algorithm technique. The cloud-based data center system, consisting of Virtual Machines has been simulated on CloudSim – a Java based cloud simulator

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Progress and status of APEmille

We report on the progress and status of the APEmille project: a SIMD parallel computer with a peak performance in the TeraFlops range which is now in an advanced development phase. We discuss the hardware and software architecture, and present some performance estimates for Lattice Gauge Theory (LGT) applications.Comment: Talk presented at LATTICE97, 3 pages, Late