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Deep learning for cardiac image segmentation: A review
Deep learning has become the most widely used approach for cardiac image segmentation in recent years. In this paper, we provide a review of over 100 cardiac image segmentation papers using deep learning, which covers common imaging modalities including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US) and major anatomical structures of interest (ventricles, atria and vessels). In addition, a summary of publicly available cardiac image datasets and code repositories are included to provide a base for encouraging reproducible research. Finally, we discuss the challenges and limitations with current deep learning-based approaches (scarcity of labels, model generalizability across different domains, interpretability) and suggest potential directions for future research
Deep Learning in Cardiology
The medical field is creating large amount of data that physicians are unable
to decipher and use efficiently. Moreover, rule-based expert systems are
inefficient in solving complicated medical tasks or for creating insights using
big data. Deep learning has emerged as a more accurate and effective technology
in a wide range of medical problems such as diagnosis, prediction and
intervention. Deep learning is a representation learning method that consists
of layers that transform the data non-linearly, thus, revealing hierarchical
relationships and structures. In this review we survey deep learning
application papers that use structured data, signal and imaging modalities from
cardiology. We discuss the advantages and limitations of applying deep learning
in cardiology that also apply in medicine in general, while proposing certain
directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table
Automatic Segmentation and Disease Classification Using Cardiac Cine MR Images
Segmentation of the heart in cardiac cine MR is clinically used to quantify
cardiac function. We propose a fully automatic method for segmentation and
disease classification using cardiac cine MR images. A convolutional neural
network (CNN) was designed to simultaneously segment the left ventricle (LV),
right ventricle (RV) and myocardium in end-diastole (ED) and end-systole (ES)
images. Features derived from the obtained segmentations were used in a Random
Forest classifier to label patients as suffering from dilated cardiomyopathy,
hypertrophic cardiomyopathy, heart failure following myocardial infarction,
right ventricular abnormality, or no cardiac disease. The method was developed
and evaluated using a balanced dataset containing images of 100 patients, which
was provided in the MICCAI 2017 automated cardiac diagnosis challenge (ACDC).
The segmentation and classification pipeline were evaluated in a four-fold
stratified cross-validation. Average Dice scores between reference and
automatically obtained segmentations were 0.94, 0.88 and 0.87 for the LV, RV
and myocardium. The classifier assigned 91% of patients to the correct disease
category. Segmentation and disease classification took 5 s per patient. The
results of our study suggest that image-based diagnosis using cine MR cardiac
scans can be performed automatically with high accuracy.Comment: Accepted in STACOM Automated Cardiac Diagnosis Challenge 201
Explainable cardiac pathology classification on cine MRI with motion characterization by semi-supervised learning of apparent flow
We propose a method to classify cardiac pathology based on a novel approach
to extract image derived features to characterize the shape and motion of the
heart. An original semi-supervised learning procedure, which makes efficient
use of a large amount of non-segmented images and a small amount of images
segmented manually by experts, is developed to generate pixel-wise apparent
flow between two time points of a 2D+t cine MRI image sequence. Combining the
apparent flow maps and cardiac segmentation masks, we obtain a local apparent
flow corresponding to the 2D motion of myocardium and ventricular cavities.
This leads to the generation of time series of the radius and thickness of
myocardial segments to represent cardiac motion. These time series of motion
features are reliable and explainable characteristics of pathological cardiac
motion. Furthermore, they are combined with shape-related features to classify
cardiac pathologies. Using only nine feature values as input, we propose an
explainable, simple and flexible model for pathology classification. On ACDC
training set and testing set, the model achieves 95% and 94% respectively as
classification accuracy. Its performance is hence comparable to that of the
state-of-the-art. Comparison with various other models is performed to outline
some advantages of our model
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