MULTI-FEATURE ANALYSIS OF EEG SIGNAL ON SEIZURE PATTERNS AND DEEP NEURAL STRUCTURES FOR PREDICTION OF EPILEPTIC SEIZURES

This work investigates EEG signal processing and seizure prediction based on deep learning architectures. The research includes two major parts. In the first part, we use wavelet decomposition to process the signals and extract signal features from the time-frequency bands. The second part examines the machine learning model and deep learning architecture we have developed for seizure pattern analysis. In our design, the extracted feature maps are processed as image inputs into our convolutional neural network (CNN) model. We proposed a combined CNN-LSTM model to directly process the EEG signals with layers functioning as feature extractors. In cross-validation testing, our CNN feature model can reach an accuracy of 96% and our CNN-LSTM model could reach an accuracy of 98%. We also proposed a matching network architecture that employs two parallel multilayer channels to improve sensitivity

The Use of EEG-fMRI Features for Characterizing Mental Disorders

Determining clinically relevant biomarkers of mental disorders for reliably indicating pathophysiological processes or predicting therapeutic responses remains a major challenge, despite decades of research. Identifying such biomarkers can help patients significantly improve their quality of life and alleviate their suffering. Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are non-invasive tools to investigate neurobiological mechanisms underlying mental disorders. Extracting and leveraging informative features from the high temporal resolution EEG and high spatial resolution fMRI may offer a more comprehensive understanding of brain spatial and temporal activities in health and disease. More importantly, this information can lead to a better understanding of the neurobiology of mental illness. This dissertation investigates the analyses and applications of extracting and combining informative features from EEG and fMRI, along with applying machine learning (ML) and computational methods for building biomarkers of mental illnesses. Several methodological challenges in the extraction of informative and reproducible features are also addressed. First, two types of EEG features obtained from resting state EEG-fMRI measurements were extracted: 1) broadband-multichannel EEG dynamical features, called EEG microstates (EEG-ms); and 2) heterogeneous, static EEG features. Using EEG features only, results elucidate that: 1) EEG-ms characteristics and information theoretical properties can successfully differentiate individuals with mood and anxiety disorders from healthy comparison subjects with potential applications for other clinical groups; and 2) heterogeneous static EEG features can successfully predict “brain aging,” noted here as BrainAGE from 468 EEG datasets, achieving a correlation of r=0.61 between predicted age and chronological age. Next, extracted EEG features were leveraged with fMRI to enhance the predictivity of BrainAGE and localizing the associated EEG-ms brain regions. More specifically, static EEG features were combined with resting state fMRI features to construct a multimodal BrainAGE predictor as a case study. Notably, it was found that EEG and fMRI contain a large portion of shared information about age, although each modality has its fingerprint of the aging process. The developed approach is a general purpose and be applied to predict other outcomes from brain imaging data. Similarly, EEG-ms features were integrated with fMRI to localize associated brain regions within fMRI space, revealing functional brain connectivity changes in individuals with mood and anxiety disorders as a case study. As a result, harnessing combined EEG-fMRI methods have enriched our knowledge some mental disorders and broadened our understanding of them with potential applications for other clinical groups and outcomes. Finally, this work evaluated the reproducibility and replication of EEG-ms analysis to address technical issues that have thus far been overlooked in the literature. In conclusion, the presented work describes technical methods developed to study and discover several clinically translatable biomarkers that can be reliably used to characterize various mental disorders

The Use of Advanced Soft Computing for Machinery Condition Monitoring

The demand for cost effective, reliable and safe machinery operation requires accurate fault detection and classification. These issues are of paramount importance as potential failures of rotating and reciprocating machinery can be managed properly and avoided in some cases. Various methods have been applied to tackle these issues, but the accuracy of those methods is variable and leaves scope for improvement. This research proposes appropriate methods for fault detection and diagnosis. The main consideration of this study is use Artificial Intelligence (AI) and related mathematics approaches to build a condition monitoring (CM) system that has incremental learning capabilities to select effective diagnostic features for the fault diagnosis of a reciprocating compressor (RC). The investigation involved a series of experiments conducted on a two-stage RC at baseline condition and then with faults introduced into the intercooler, drive belt and 2nd stage discharge and suction valve respectively. In addition to this, three combined faults: discharge valve leakage combined with intercooler leakage, suction valve leakage combined with intercooler leakage and discharge valve leakage combined with suction valve leakage were created and simulated to test the model. The vibration data was collected from the experimental RC and processed through pre-processing stage, features extraction, features selection before the developed diagnosis and classification model were built. A large number of potential features are calculated from the time domain, the frequency domain and the envelope spectrum. Applying Neural Networks (NNs), Support Vector Machines (SVMs), Relevance Vector Machines (RVMs) which integrate with Genetic Algorithms (GAs), and principle components analysis (PCA) which cooperates with principle components optimisation, to these features, has found that the features from envelope analysis have the most potential for differentiating various common faults in RCs. The practical results for fault detection, diagnosis and classification show that the proposed methods perform very well and accurately and can be used as effective tools for diagnosing reciprocating machinery failure