562 research outputs found
Pre and Post-hoc Diagnosis and Interpretation of Malignancy from Breast DCE-MRI
We propose a new method for breast cancer screening from DCE-MRI based on a
post-hoc approach that is trained using weakly annotated data (i.e., labels are
available only at the image level without any lesion delineation). Our proposed
post-hoc method automatically diagnosis the whole volume and, for positive
cases, it localizes the malignant lesions that led to such diagnosis.
Conversely, traditional approaches follow a pre-hoc approach that initially
localises suspicious areas that are subsequently classified to establish the
breast malignancy -- this approach is trained using strongly annotated data
(i.e., it needs a delineation and classification of all lesions in an image).
Another goal of this paper is to establish the advantages and disadvantages of
both approaches when applied to breast screening from DCE-MRI. Relying on
experiments on a breast DCE-MRI dataset that contains scans of 117 patients,
our results show that the post-hoc method is more accurate for diagnosing the
whole volume per patient, achieving an AUC of 0.91, while the pre-hoc method
achieves an AUC of 0.81. However, the performance for localising the malignant
lesions remains challenging for the post-hoc method due to the weakly labelled
dataset employed during training.Comment: Submitted to Medical Image Analysi
Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions
Breast cancer has reached the highest incidence rate worldwide among all
malignancies since 2020. Breast imaging plays a significant role in early
diagnosis and intervention to improve the outcome of breast cancer patients. In
the past decade, deep learning has shown remarkable progress in breast cancer
imaging analysis, holding great promise in interpreting the rich information
and complex context of breast imaging modalities. Considering the rapid
improvement in the deep learning technology and the increasing severity of
breast cancer, it is critical to summarize past progress and identify future
challenges to be addressed. In this paper, we provide an extensive survey of
deep learning-based breast cancer imaging research, covering studies on
mammogram, ultrasound, magnetic resonance imaging, and digital pathology images
over the past decade. The major deep learning methods, publicly available
datasets, and applications on imaging-based screening, diagnosis, treatment
response prediction, and prognosis are described in detail. Drawn from the
findings of this survey, we present a comprehensive discussion of the
challenges and potential avenues for future research in deep learning-based
breast cancer imaging.Comment: Survey, 41 page
AI-enhanced diagnosis of challenging lesions in breast MRI: a methodology and application primer
Computer-aided diagnosis (CAD) systems have become an important tool in the assessment of breast tumors with magnetic resonance imaging (MRI). CAD systems can be used for the detection and diagnosis of breast tumors as a “second opinion” review complementing the radiologist’s review. CAD systems have many common parts such as image pre-processing, tumor feature extraction and data classification that are mostly based on machine learning (ML) techniques. In this review paper, we describe the application of ML-based CAD systems in MRI of the breast covering the detection of diagnostically challenging lesions such as non-mass enhancing (NME) lesions, multiparametric MRI, neo-adjuvant chemotherapy (NAC) and radiomics all applied to NME. Since ML has been widely used in the medical imaging community, we provide an overview about the state-ofthe-art and novel techniques applied as classifiers to CAD systems. The differences in the CAD systems in MRI of the breast for several standard and novel applications for NME are explained in detail to provide important examples illustrating: (i) CAD for the detection and diagnosis, (ii) CAD in multi-parametric imaging (iii) CAD in NAC and (iv) breast cancer radiomics. We aim to provide a comparison between these CAD applications and to illustrate a global view on intelligent CAD systems based on ANN in MRI of the breast
Modified fuzzy rough set technique with stacked autoencoder model for magnetic resonance imaging based breast cancer detection
Breast cancer is the common cancer in women, where early detection reduces the mortality rate. The magnetic resonance imaging (MRI) images are efficient in analyzing breast cancer, but it is hard to identify the abnormalities. The manual breast cancer detection in MRI images is inefficient; therefore, a deep learning-based system is implemented in this manuscript. Initially, the visual quality improvement is done using region growing and adaptive histogram equalization (AHE), and then, the breast lesion is segmented by Otsu thresholding with morphological transform. Next, the features are extracted from the segmented lesion, and a modified fuzzy rough set technique is proposed to reduce the dimensions of the extracted features that decreases the system complexity and computational time. The active features are fed to the stacked autoencoder for classifying the benign and malignant classes. The results demonstrated that the proposed model attained 99% and 99.22% of classification accuracy on the benchmark datasets, which are higher related to the comparative classifiers: decision tree, naĂŻve Bayes, random forest and k-nearest neighbor (KNN). The obtained results state that the proposed model superiorly screens and detects the breast lesions that assists clinicians in effective therapeutic intervention and timely treatment
A Survey on Deep Learning in Medical Image Analysis
Deep learning algorithms, in particular convolutional networks, have rapidly
become a methodology of choice for analyzing medical images. This paper reviews
the major deep learning concepts pertinent to medical image analysis and
summarizes over 300 contributions to the field, most of which appeared in the
last year. We survey the use of deep learning for image classification, object
detection, segmentation, registration, and other tasks and provide concise
overviews of studies per application area. Open challenges and directions for
future research are discussed.Comment: Revised survey includes expanded discussion section and reworked
introductory section on common deep architectures. Added missed papers from
before Feb 1st 201
SimPLe: Similarity-Aware Propagation Learning for Weakly-Supervised Breast Cancer Segmentation in DCE-MRI
Breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays
an important role in the screening and prognosis assessment of high-risk breast
cancer. The segmentation of cancerous regions is essential useful for the
subsequent analysis of breast MRI. To alleviate the annotation effort to train
the segmentation networks, we propose a weakly-supervised strategy using
extreme points as annotations for breast cancer segmentation. Without using any
bells and whistles, our strategy focuses on fully exploiting the learning
capability of the routine training procedure, i.e., the train - fine-tune -
retrain process. The network first utilizes the pseudo-masks generated using
the extreme points to train itself, by minimizing a contrastive loss, which
encourages the network to learn more representative features for cancerous
voxels. Then the trained network fine-tunes itself by using a similarity-aware
propagation learning (SimPLe) strategy, which leverages feature similarity
between unlabeled and positive voxels to propagate labels. Finally the network
retrains itself by employing the pseudo-masks generated using previous
fine-tuned network. The proposed method is evaluated on our collected DCE-MRI
dataset containing 206 patients with biopsy-proven breast cancers. Experimental
results demonstrate our method effectively fine-tunes the network by using the
SimPLe strategy, and achieves a mean Dice value of 81%
- …