Emergent networks in immune system shape space

The development of a computational model is reported which facilitates the study of emergent principles of human immune system effector T cell clonotype repertoire and its distribution and differentiation. In particular, the question of systemic self-organisation is addressed. The model represents an extension to earlier immune system shape space formalism, such that each activated effector T cell clonotype and respective immunogenic viral epitope is represented as a node in a two-dimensional network space, and edges between nodes models the affinity and clearance pressure applied to the antigen presenting cell bearing the target epitope. As the model is repeatedly exposed to infection by heterologous or mutating viruses, a distinct topology of the network shape space emerges which may offer a theoretical explanation of recent biological experimental results in the field of murine (mouse) cytotoxic T cell activation, apoptosis, crossreactivity, and memory - especially with respect to repeated reinfection. In the past, most discrete computational models of immune response to vira l infections have used separate real space or shape space formalisms. In this work, however, we have developed a model based on a combination of the two, with the objective of demonstrating how emergent behaviour and principles of self organisation may arise from a many-particle microscopic system. This is achieved by using a stochastic model of the lymphatic system as stimulus to a networ

The suitability of the dendritic cell algorithm for robotic security applications

The implementation and running of physical security systems is costly and potentially hazardous for those employed to patrol areas of interest. From a technial perspective, the physical security problem can be seen as minimising the probability that intruders and other anomalous events will occur unobserved. A robotic solution is proposed using an artificial immune system, traditionally applied to software security, to identify threats and hazards: the dendritic cell algorithm. It is demonstrated that the migration from the software world to the hardware world is achievable for this algorithm and key properties of the resulting system are explored empirically and theoretically. It is found that the algorithm has a hitherto unknown frequency-dependent component, making it ideal for filtering out sensor noise. Weaknesses of the algorithm are also discovered, by mathematically phrasing the signal processing phase as a collection of linear classifiers. It is concluded that traditional machine learning approaches are likely to outperform the implemented system in its current form. However, it is also observed that the algorithm’s inherent filtering characteristics make modification, rather than rejection, the most beneficial course of action. Hybridising the dendritic cell algorithm with more traditional machine learning techniques, through the introduction of a training phase and using a non-linear classification phase is suggested as a possible future direction

Immune System Based Control and Intelligent Agent Design for Power System Applications

The National Academy of Engineering has selected the US Electric Power Grid as the supreme engineering achievement of the 20th century. Yet, this same grid is struggling to keep up with the increasing demand for electricity, its quality and cost. A growing recognition of the need to modernize the grid to meet future challenges has found articulation in the vision of a Smart Grid in using new control strategies that are intelligent, distributed, and adaptive. The objective of this work is to develop smart control systems inspired from the biological Human Immune System to better manage the power grid at the both generation and distribution levels. The work is divided into three main sections. In the first section, we addressed the problem of Automatic Generation Control design. The Clonal Selection theory is successfully applied as an optimization technique to obtain decentralized control gains that minimize a performance index based on Area Control Errors. Then the Immune Network theory is used to design adaptive controllers in order to diminish the excess maneuvering of the units and help the control areas comply with the North American Electric Reliability Corporation\u27s standards set to insure good quality of service and equitable mutual assistance by the interconnected energy balancing areas. The second section of this work addresses the design and deployment of Multi Agent Systems on both terrestrial and shipboard power systems self-healing using a novel approach based on the Immune Multi-Agent System (IMAS). The Immune System is viewed as a highly organized and distributed Multi-Cell System that strives to heal the body by working together and communicating to get rid of the pathogens. In this work both simulation and hardware design and deployment of the MAS are addressed. The third section of this work consists in developing a small scale smart circuit by modifying and upgrading the existing Analog Power Simulator to demonstrate the effectiveness of the developed technologies. We showed how to develop smart Agents hardware along with a wireless communication platform and the electronic switches. After putting together the different designed pieces, the resulting Multi Agent System is integrated into the Power Simulator Hardware. The multi Agent System developed is tested for fault isolation, reconfiguration, and restoration problems by simulating a permanent three phase fault on one of the feeder lines. The experimental results show that the Multi Agent System hardware developed performed effectively and in a timely manner which confirms that this technology is very promising and a very good candidate for Smart Grid control applications

The suitability of the dendritic cell algorithm for robotic security applications

The implementation and running of physical security systems is costly and potentially hazardous for those employed to patrol areas of interest. From a technial perspective, the physical security problem can be seen as minimising the probability that intruders and other anomalous events will occur unobserved. A robotic solution is proposed using an artificial immune system, traditionally applied to software security, to identify threats and hazards: the dendritic cell algorithm. It is demonstrated that the migration from the software world to the hardware world is achievable for this algorithm and key properties of the resulting system are explored empirically and theoretically. It is found that the algorithm has a hitherto unknown frequency-dependent component, making it ideal for filtering out sensor noise. Weaknesses of the algorithm are also discovered, by mathematically phrasing the signal processing phase as a collection of linear classifiers. It is concluded that traditional machine learning approaches are likely to outperform the implemented system in its current form. However, it is also observed that the algorithm’s inherent filtering characteristics make modification, rather than rejection, the most beneficial course of action. Hybridising the dendritic cell algorithm with more traditional machine learning techniques, through the introduction of a training phase and using a non-linear classification phase is suggested as a possible future direction

Using MapReduce Streaming for Distributed Life Simulation on the Cloud

Distributed software simulations are indispensable in the study of large-scale life models but often require the use of technically complex lower-level distributed computing frameworks, such as MPI. We propose to overcome the complexity challenge by applying the emerging MapReduce (MR) model to distributed life simulations and by running such simulations on the cloud. Technically, we design optimized MR streaming algorithms for discrete and continuous versions of Conway’s life according to a general MR streaming pattern. We chose life because it is simple enough as a testbed for MR’s applicability to a-life simulations and general enough to make our results applicable to various lattice-based a-life models. We implement and empirically evaluate our algorithms’ performance on Amazon’s Elastic MR cloud. Our experiments demonstrate that a single MR optimization technique called strip partitioning can reduce the execution time of continuous life simulations by 64%. To the best of our knowledge, we are the first to propose and evaluate MR streaming algorithms for lattice-based simulations. Our algorithms can serve as prototypes in the development of novel MR simulation algorithms for large-scale lattice-based a-life models.https://digitalcommons.chapman.edu/scs_books/1014/thumbnail.jp

AI Solutions for MDS: Artificial Intelligence Techniques for Misuse Detection and Localisation in Telecommunication Environments

This report considers the application of Articial Intelligence (AI) techniques to the problem of misuse detection and misuse localisation within telecommunications environments. A broad survey of techniques is provided, that covers inter alia rule based systems, model-based systems, case based reasoning, pattern matching, clustering and feature extraction, articial neural networks, genetic algorithms, arti cial immune systems, agent based systems, data mining and a variety of hybrid approaches. The report then considers the central issue of event correlation, that is at the heart of many misuse detection and localisation systems. The notion of being able to infer misuse by the correlation of individual temporally distributed events within a multiple data stream environment is explored, and a range of techniques, covering model based approaches, `programmed' AI and machine learning paradigms. It is found that, in general, correlation is best achieved via rule based approaches, but that these suffer from a number of drawbacks, such as the difculty of developing and maintaining an appropriate knowledge base, and the lack of ability to generalise from known misuses to new unseen misuses. Two distinct approaches are evident. One attempts to encode knowledge of known misuses, typically within rules, and use this to screen events. This approach cannot generally detect misuses for which it has not been programmed, i.e. it is prone to issuing false negatives. The other attempts to `learn' the features of event patterns that constitute normal behaviour, and, by observing patterns that do not match expected behaviour, detect when a misuse has occurred. This approach is prone to issuing false positives, i.e. inferring misuse from innocent patterns of behaviour that the system was not trained to recognise. Contemporary approaches are seen to favour hybridisation, often combining detection or localisation mechanisms for both abnormal and normal behaviour, the former to capture known cases of misuse, the latter to capture unknown cases. In some systems, these mechanisms even work together to update each other to increase detection rates and lower false positive rates. It is concluded that hybridisation offers the most promising future direction, but that a rule or state based component is likely to remain, being the most natural approach to the correlation of complex events. The challenge, then, is to mitigate the weaknesses of canonical programmed systems such that learning, generalisation and adaptation are more readily facilitated

Nature-inspired survivability: Prey-inspired survivability countermeasures for cloud computing security challenges

As cloud computing environments become complex, adversaries have become highly sophisticated and unpredictable. Moreover, they can easily increase attack power and persist longer before detection. Uncertain malicious actions, latent risks, Unobserved or Unobservable risks (UUURs) characterise this new threat domain. This thesis proposes prey-inspired survivability to address unpredictable security challenges borne out of UUURs. While survivability is a well-addressed phenomenon in non-extinct prey animals, applying prey survivability to cloud computing directly is challenging due to contradicting end goals. How to manage evolving survivability goals and requirements under contradicting environmental conditions adds to the challenges. To address these challenges, this thesis proposes a holistic taxonomy which integrate multiple and disparate perspectives of cloud security challenges. In addition, it proposes the TRIZ (Teorija Rezbenija Izobretatelskib Zadach) to derive prey-inspired solutions through resolving contradiction. First, it develops a 3-step process to facilitate interdomain transfer of concepts from nature to cloud. Moreover, TRIZ’s generic approach suggests specific solutions for cloud computing survivability. Then, the thesis presents the conceptual prey-inspired cloud computing survivability framework (Pi-CCSF), built upon TRIZ derived solutions. The framework run-time is pushed to the user-space to support evolving survivability design goals. Furthermore, a target-based decision-making technique (TBDM) is proposed to manage survivability decisions. To evaluate the prey-inspired survivability concept, Pi-CCSF simulator is developed and implemented. Evaluation results shows that escalating survivability actions improve the vitality of vulnerable and compromised virtual machines (VMs) by 5% and dramatically improve their overall survivability. Hypothesis testing conclusively supports the hypothesis that the escalation mechanisms can be applied to enhance the survivability of cloud computing systems. Numeric analysis of TBDM shows that by considering survivability preferences and attitudes (these directly impacts survivability actions), the TBDM method brings unpredictable survivability information closer to decision processes. This enables efficient execution of variable escalating survivability actions, which enables the Pi-CCSF’s decision system (DS) to focus upon decisions that achieve survivability outcomes under unpredictability imposed by UUUR

Multi-layered model of individual HIV infection progression and mechanisms of phenotypical expression

Cite as: Perrin, Dimitri (2008) Multi-layered model of individual HIV infection progression and mechanisms of phenotypical expression. PhD thesis, Dublin City University