Virtual Clinical Trials: One Step Forward, Two Steps Back

Virtual clinical trials have entered the medical research landscape. Today’s clinical trials recruit subjects online, obtain informed consent online, send treatments such as medications or devices to the subjects’ homes, and require subjects to record their responses online. Virtual clinical trials could be a way to democratize clinical research and circumvent geographical limitations by allowing access to clinical research for people who live far from traditional medical research centers. But virtual clinical trials also depart dramatically from traditional medical research studies in ways that can harm individuals and the public at large. This article addresses the issues presented by virtual clinical trials with regard to: (1) recruitment methods; (2) informed consent; (3) confidentiality; (4) potential risks to the subjects; and (5) the safety and efficacy of treatments that are approved

Scenarios for the development of smart grids in the UK: synthesis report

‘Smart grid’ is a catch-all term for the smart options that could transform the ways society produces, delivers and consumes energy, and potentially the way we conceive of these services. Delivering energy more intelligently will be fundamental to decarbonising the UK electricity system at least possible cost, while maintaining security and reliability of supply. Smarter energy delivery is expected to allow the integration of more low carbon technologies and to be much more cost effective than traditional methods, as well as contributing to economic growth by opening up new business and innovation opportunities. Innovating new options for energy system management could lead to cost savings of up to £10bn, even if low carbon technologies do not emerge. This saving will be much higher if UK renewable energy targets are achieved. Building on extensive expert feedback and input, this report describes four smart grid scenarios which consider how the UK’s electricity system might develop to 2050. The scenarios outline how political decisions, as well as those made in regulation, finance, technology, consumer and social behaviour, market design or response, might affect the decisions of other actors and limit or allow the availability of future options. The project aims to explore the degree of uncertainty around the current direction of the electricity system and the complex interactions of a whole host of factors that may lead to any one of a wide range of outcomes. Our addition to this discussion will help decision makers to understand the implications of possible actions and better plan for the future, whilst recognising that it may take any one of a number of forms

Scenarios for the Internet Migration of the Television Industry

All the conditions for the television industry’s migration to the Internet are now in place. While this migration will be gradual, it will have a deep-seated impact on the industry:•the exclusive rights model will no longer be the standard;•some consumers will abandon traditional managed networks;•a globalization trend will be sparked, to the benefit of the major rights holders. Unlike the music and print media industries, the TV industry is gaining a strong position on the Web. As a result, television is poised to play a central role in video services. This offensive strategy will likely pay off down the line, but does not entirely eliminate the possibility of destroying value. There are structural reasons for this, including a fiercely competitive online advertising market and a lack of control over program circulation. Far from being simply transitory, the 2009-2010 economic downturn marks the beginning of a decade of restructuring for the TV industry. This new period will begin with an overall decline in the sector’s resources before increasingly varied consumption patterns spur a new period of growth. The decade running from 2010 to 2020 will also be a period that focuses on cost control, with the industrialization of TV production that will depart once and for all from its historical model, i.e., film. This migration to the Web poses a threat to the European industry in particular. A reassessment of the television industry’s regulatory strategy appears both necessary and urgent, and will involve the creation of integrated pan-European conglomerates.Television, video, networks, on-demand, connected devices, advertising, pay-TV.

Academics' online presence guidelines: A four step guide to taking control of your visibility

OpenUCT published Academics' online presence guidelines: A four step guide to taking control of your visibility in 2012

Mutual assessment in the social programmer ecosystem: an empirical investigation of developer profile aggregators

The multitude of social media channels that programmers can use to participate in software development has given rise to online developer profiles that aggregate activity across many services. Studying members of such developer profile aggregators, we found an ecosystem that revolves around the social programmer. Developers are assessing each other to evaluate whether other developers are interesting, worth following, or worth collaborating with. They are self-conscious about being assessed, and thus manage their public images. They value passion for software development, new technologies, and learning. Some recruiters participate in the ecosystem and use it to find candidates for hiring; other recruiters struggle with the interpretation of signals and issues of trust. This mutual assessment is changing how software engineers collaborate and how they advance their skills.Leif Singer, Fernando Figueira Filho, Brendan Cleary, Christoph Treude, Margaret-Anne Storey, Kurt Schneide

A technology and policy analysis for global E-business

Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2002.Includes bibliographical references (p. 49-51).We introduce an e-business analytical framework that focuses on transaction flows, including information, physical goods, and services. Within this framework, global e-business involves transaction flows that cross both organizational and national boundaries. Many challenging technology and policy issues arise from this trans-boundary characteristic of global e-business. These issues are analyzed using web aggregation as an example global e-business application. We start the analysis by introducing web aggregation services and their enabling technologies. Our survey of current status of web aggregation indicates that most services are still operated regionally despite their global presence. Although benefits of web aggregation have been realized in regions with extensive use of information aggregation, little is done at the global level. Our case study on worldwide price distribution of a nearly homogeneous consumer electronics product indicates great potential for global aggregation to bring information and efficiency to the global market. In addition to lack of global integration, we identified other deficiencies of web aggregation. Technological challenges and possible solutions to overcoming these deficiencies are discussed. However, having technological capability for trans-boundary information flow does not solve all problems in global aggregation. National policies often prohibit such flow into nations that have different policies, especially in database and privacy protection areas. We analyze these policy issues and propose future research on international policy harmonization.by Hongwei Zhu.S.M

Recommender systems and their ethical challenges

This article presents the first, systematic analysis of the ethical challenges posed by recommender systems through a literature review. The article identifies six areas of concern, and maps them onto a proposed taxonomy of different kinds of ethical impact. The analysis uncovers a gap in the literature: currently user-centred approaches do not consider the interests of a variety of other stakeholders—as opposed to just the receivers of a recommendation—in assessing the ethical impacts of a recommender system