66,877 research outputs found
Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing
We propose a flexible change-point model for inhomogeneous Poisson Processes,
which arise naturally from next-generation DNA sequencing, and derive score and
generalized likelihood statistics for shifts in intensity functions. We
construct a modified Bayesian information criterion (mBIC) to guide model
selection, and point-wise approximate Bayesian confidence intervals for
assessing the confidence in the segmentation. The model is applied to DNA Copy
Number profiling with sequencing data and evaluated on simulated spike-in and
real data sets.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS517 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Rapid Sampling for Visualizations with Ordering Guarantees
Visualizations are frequently used as a means to understand trends and gather
insights from datasets, but often take a long time to generate. In this paper,
we focus on the problem of rapidly generating approximate visualizations while
preserving crucial visual proper- ties of interest to analysts. Our primary
focus will be on sampling algorithms that preserve the visual property of
ordering; our techniques will also apply to some other visual properties. For
instance, our algorithms can be used to generate an approximate visualization
of a bar chart very rapidly, where the comparisons between any two bars are
correct. We formally show that our sampling algorithms are generally applicable
and provably optimal in theory, in that they do not take more samples than
necessary to generate the visualizations with ordering guarantees. They also
work well in practice, correctly ordering output groups while taking orders of
magnitude fewer samples and much less time than conventional sampling schemes.Comment: Tech Report. 17 pages. Condensed version to appear in VLDB Vol. 8 No.
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