Automated classification of blasts in acute leukemia blood samples using HMLP network

This paper presents a study on classification of blasts in acute leukemia blood samples using artificial neural network.In acute leukemia there are two major forms that are acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL).Six morphological features have been extracted from acute leukemia blood images and used as neural network inputs for the classification.Hybrid Multilayer Perceptron (HMLP) neural network was used to perform the classification task.The Hybrid Multilayer Perceptron(HMLP) neural network is trained using modified RPE(MRPE) training algorithm for 1474 data samples.The Hybrid Multilayer Perceptron (HMLP) neural network produces 97.04% performance accuracy.The result indicates the promising capabilities and abilities of the Hybrid Multilayer Perceptron (HMLP) neural network using modified RPE (MRPE) training algorithm for classifying and distinguishing the blasts from acute leukemia blood samples

Differential gene expression graphs: A data structure for classification in DNA microarrays

This paper proposes an innovative data structure to be used as a backbone in designing microarray phenotype sample classifiers. The data structure is based on graphs and it is built from a differential analysis of the expression levels of healthy and diseased tissue samples in a microarray dataset. The proposed data structure is built in such a way that, by construction, it shows a number of properties that are perfectly suited to address several problems like feature extraction, clustering, and classificatio

A graph-based representation of Gene Expression profiles in DNA microarrays

This paper proposes a new and very flexible data model, called gene expression graph (GEG), for genes expression analysis and classification. Three features differentiate GEGs from other available microarray data representation structures: (i) the memory occupation of a GEG is independent of the number of samples used to built it; (ii) a GEG more clearly expresses relationships among expressed and non expressed genes in both healthy and diseased tissues experiments; (iii) GEGs allow to easily implement very efficient classifiers. The paper also presents a simple classifier for sample-based classification to show the flexibility and user-friendliness of the proposed data structur

Classification of fundus images for diabetic retinopathy using artificial neural network

People with diabetes may suffer from an eye disease called Diabetic Retinopathy (DR). This is caused by damage to the blood vessels of the light-sensitive tissue at the back of the eye (i.e retina). Fundus images obtained from fundus camera are often imperfect; normally are in low contrast and blurry. Hence, causing difficulty in accurately classifying diabetic retinopathy disease. This study focuses on classification of fundus image that contains with or without signs of DR and utilizes artificial neural network (NN) namely Multi-layered Perceptron (MLP) trained by Levenberg-Marquardt (LM) and Bayesian Regularization (BR) to classify the data. Nineteen features have been extracted from fundus image and used as neural network inputs for the classification. For analysis, evaluation were made using different number of hidden nodes. It is learned that MLP trained with BR provides a better classification performance with 72.11% (training) and 67.47% (testing) as compared to the use of LM. Such a finding indicates the possibility of utilizing BR for other artificial neural network model

Microarray-based cancer prediction using single genes

<p>Abstract</p> <p>Background</p> <p>Although numerous methods of using microarray data analysis for cancer classification have been proposed, most utilize many genes to achieve accurate classification. This can hamper interpretability of the models and ease of translation to other assay platforms. We explored the use of single genes to construct classification models. We first identified the genes with the most powerful univariate class discrimination ability and then constructed simple classification rules for class prediction using the single genes.</p> <p>Results</p> <p>We applied our model development algorithm to eleven cancer gene expression datasets and compared classification accuracy to that for standard methods including Diagonal Linear Discriminant Analysis, <it>k</it>-Nearest Neighbor, Support Vector Machine and Random Forest. The single gene classifiers provided classification accuracy comparable to or better than those obtained by existing methods in most cases. We analyzed the factors that determined when simple single gene classification is effective and when more complex modeling is warranted.</p> <p>Conclusions</p> <p>For most of the datasets examined, the single-gene classification methods appear to work as well as more standard methods, suggesting that simple models could perform well in microarray-based cancer prediction.</p

FedPNN: One-shot Federated Classification via Evolving Clustering Method and Probabilistic Neural Network hybrid

Protecting data privacy is paramount in the fields such as finance, banking, and healthcare. Federated Learning (FL) has attracted widespread attention due to its decentralized, distributed training and the ability to protect the privacy while obtaining a global shared model. However, FL presents challenges such as communication overhead, and limited resource capability. This motivated us to propose a two-stage federated learning approach toward the objective of privacy protection, which is a first-of-its-kind study as follows: (i) During the first stage, the synthetic dataset is generated by employing two different distributions as noise to the vanilla conditional tabular generative adversarial neural network (CTGAN) resulting in modified CTGAN, and (ii) In the second stage, the Federated Probabilistic Neural Network (FedPNN) is developed and employed for building globally shared classification model. We also employed synthetic dataset metrics to check the quality of the generated synthetic dataset. Further, we proposed a meta-clustering algorithm whereby the cluster centers obtained from the clients are clustered at the server for training the global model. Despite PNN being a one-pass learning classifier, its complexity depends on the training data size. Therefore, we employed a modified evolving clustering method (ECM), another one-pass algorithm to cluster the training data thereby increasing the speed further. Moreover, we conducted sensitivity analysis by varying Dthr, a hyperparameter of ECM at the server and client, one at a time. The effectiveness of our approach is validated on four finance and medical datasets.Comment: 27 pages, 13 figures, 7 table

A cDNA Microarray Gene Expression Data Classifier for Clinical Diagnostics Based on Graph Theory

Despite great advances in discovering cancer molecular profiles, the proper application of microarray technology to routine clinical diagnostics is still a challenge. Current practices in the classification of microarrays' data show two main limitations: the reliability of the training data sets used to build the classifiers, and the classifiers' performances, especially when the sample to be classified does not belong to any of the available classes. In this case, state-of-the-art algorithms usually produce a high rate of false positives that, in real diagnostic applications, are unacceptable. To address this problem, this paper presents a new cDNA microarray data classification algorithm based on graph theory and is able to overcome most of the limitations of known classification methodologies. The classifier works by analyzing gene expression data organized in an innovative data structure based on graphs, where vertices correspond to genes and edges to gene expression relationships. To demonstrate the novelty of the proposed approach, the authors present an experimental performance comparison between the proposed classifier and several state-of-the-art classification algorithm