Making Study Populations Visible through Knowledge Graphs

Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommendations, they need to understand how well their patient population matches the characteristics of those in the study cohort, and thus are confronted with the challenges of locating the study cohort information and making an analytic comparison. To address these challenges, we develop an ontology-enabled prototype system, which exposes the population descriptions in research studies in a declarative manner, with the ultimate goal of allowing medical practitioners to better understand the applicability and generalizability of treatment recommendations. We build a Study Cohort Ontology (SCO) to encode the vocabulary of study population descriptions, that are often reported in the first table in the published work, thus they are often referred to as Table 1. We leverage the well-used Semanticscience Integrated Ontology (SIO) for defining property associations between classes. Further, we model the key components of Table 1s, i.e., collections of study subjects, subject characteristics, and statistical measures in RDF knowledge graphs. We design scenarios for medical practitioners to perform population analysis, and generate cohort similarity visualizations to determine the applicability of a study population to the clinical population of interest. Our semantic approach to make study populations visible, by standardized representations of Table 1s, allows users to quickly derive clinically relevant inferences about study populations.Comment: 16 pages, 4 figures, 1 table, accepted to the ISWC 2019 Resources Track (https://iswc2019.semanticweb.org/call-for-resources-track-papers/

Collaborative Research Practices and Shared Infrastructures for Humanities Computing

The volume collect the proceedings of the 2nd Annual Conference of the Italian Association for Digital Humanities (Aiucd 2013), which took place at the Department of Information Engineering of the University of Padua, 11-12 December 2013. The general theme of Aiucd 2013 was “Collaborative Research Practices and Shared Infrastructures for Humanities Computing” so we particularly welcomed submissions on interdisciplinary work and new developments in the field, encouraging proposals relating to the theme of the conference, or more specifically: interdisciplinarity and multidisciplinarity, legal and economic issues, tools and collaborative methodologies, measurement and impact of collaborative methodologies, sharing and collaboration methods and approaches, cultural institutions and collaborative facilities, infrastructures and digital libraries as collaborative environments, data resources and technologies sharing

Collaborative Research Practices and Shared Infrastructures for Humanities Computing

The volume collect the proceedings of the 2nd Annual Conference of the Italian Association for Digital Humanities (Aiucd 2013), which took place at the Department of Information Engineering of the University of Padua, 11-12 December 2013. The general theme of Aiucd 2013 was “Collaborative Research Practices and Shared Infrastructures for Humanities Computing” so we particularly welcomed submissions on interdisciplinary work and new developments in the field, encouraging proposals relating to the theme of the conference, or more specifically: interdisciplinarity and multidisciplinarity, legal and economic issues, tools and collaborative methodologies, measurement and impact of collaborative methodologies, sharing and collaboration methods and approaches, cultural institutions and collaborative facilities, infrastructures and digital libraries as collaborative environments, data resources and technologies sharing

Responsible AI and Analytics for an Ethical and Inclusive Digitized Society

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